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Protein Overview: HLHm5-PA

General Information:
Name(s) found: HLHm5-PA / FBpp0084352 [FlyBase]
Description(s) found:
Found 41 descriptions.
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  • The gene E(spl) region transcript m5 is referred to in FlyBase by the symbol Dmel\HLHm5 (CG6096, FBgn0002631). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21854572..21855457. It has the cytological map location 96F10. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; DNA binding. It is reported to be involved in the biological process</span>: nervous system development; compound eye development; negative regulation of transcription; cell fate commitment. 18 alleles are reported. The phenotypes of these alleles are annotated with: central nervous system; macrochaeta; peripheral nervous system; microchaeta; eo neuron. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 178 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: negative regulation of transcription [NAS]
    cell fate commitment [NAS]
    nervous system development [NAS]
    regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IEA]
    compound eye development [TAS]
    Molecular Function: DNA binding [IDA][NAS]
    transcription factor activity [TAS]
    transcription regulator activity [IEA]
    sequence-specific DNA binding [IDA]
    specific transcriptional repressor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPQSNNSTT FVSKTQHYLK VKKPLLERQR RARMNKCLDT LKTLVAEFQG DDAILRMDKA  60
   61 EMLEAALVFM RKQVVKQQAP VSPLPMDSFK NGYMNAVSEI SRVMACTPAM SVDVGKTVMT 120
  121 HLGVEFQRML QADQVQTSVT TSTPRPLSPA SSGYHSDNED SQSAASPKPV EETMWRPW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] PSI-BLAST 13.522879 SREBP-1a
    2 View Details [82..178] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle