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Protein Overview: FBpp0292528, CG1...

General Information:
Name(s) found: FBpp0292528 [FlyBase]
CG11089-PA / FBpp0084087 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • type=protein; loc=3R:join(20704823..20704841,20704899..20705971,20706035..20706468,20706528..20706654,20706716..20706835); ID=FBpp0292528; name=CG11089-PB; parent=FBgn0039241,FBtr0303476; dbxref=FlyBase:FBpp0292528,FlyBase_Annotation_IDs:CG11089-PB,REFSEQ:NP_001189286,GB_protein:ADV37376; MD5=55ef89080f4f9340468020148f4f0336; length=590; release=r5.56; species=Dmel; [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG11089 (CG11089, FBgn0039241). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20702790..20707200. It has the cytological map location 96B2. Based on sequence similarity, it is predicted to have molecular function</span>: phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IMP cyclohydrolase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: IMP biosynthetic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 590 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: IMP biosynthetic process [IEA]
    Molecular Function: IMP cyclohydrolase activity [ISS]
    phosphoribosylaminoimidazolecarboxamide formyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSKIALLS VSDKTGLLDL GKSLVALGFD LVASGGTATS LRGAGLKVRD VSEITGAPEM  60
   61 LGGRVKTLHP AVHAGILSRT TDSDLADMRK QGFDLIQLVV CNLYPFASTV AKPDVTLADA 120
  121 VENIDIGGVT LLRAAAKNHQ RVTVVCEAVD YDRVLSELKA SGNTTVETRQ ALALKAFTHT 180
  181 ATYDDAISDY FRKQYGSGVS QLPLRYGMNP HQKPAQLYTQ LAKLPLTVLN ASPGFINLCD 240
  241 ALNGWQLVRE LKKALQLPAA TSFKHVSPAG AAVGVPLNPA QAKLCMVDDL YEQLTPLATA 300
  301 YARARGADRM SSFGDFVALS DVCDVVTARI ISREVSDGII AAGYEPEALE ILKKKKNGGY 360
  361 CILQMDPNYE PSAVERKTIF GLTLEQKRND AVIDASLFSN VVSKRGPLPE VAVRDLIVAT 420
  421 IALKYTQSNS VCYARDGQVV GIGAGQQSRI HCTRLAGEKA DNWWLRQHPS VAGMKFKAGV 480
  481 KRAEISNAID NYVNGTVGKD MPLSQFEGMF DKAPAQLTSE QKVEWLKQLS GVALGSDAFF 540
  541 PFRDNIDRAS LSGVSYIASP AGSTNDAGVI AACDEHGIIM AHTNLRLFHH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..590] PSI-BLAST 1000.0 Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • IMP cyclohydrolase activity
    		•  2.44338227123463 bayes_pls_golite062009
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity
    		•  2.17104645465987 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  2.1190774640451 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.79965948308471 bayes_pls_golite062009
  • catalytic activity
    		•  1.70756445127105 bayes_pls_golite062009
  • hydroxymethyl-, formyl- and related transferase activity
    		•  1.51378035087272 bayes_pls_golite062009
  • binding
    		•  1.21541060770936 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  1.19388272840449 bayes_pls_golite062009
  • deaminase activity
    		•  1.16510523659661 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.03324558866637 bayes_pls_golite062009
  • cytidine deaminase activity
    		•  0.870445440530128 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.738911503392967 bayes_pls_golite062009
  • carbon-oxygen lyase activity, acting on phosphates
    		•  0.344740566585736 bayes_pls_golite062009
  • electron carrier activity
    		•  0.178707818321223 bayes_pls_golite062009
  • protein binding
    		•  0.072557222523031 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.60

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle