Protein Overview: crb-PA

General Information:
Name(s) found:	crb-PA / FBpp0083987 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7301143\|gb\|AAF56276.1\| crumbs, isoform A [Drosophila melanogaster] [NCBI NR] gi\|68067441\|sp\|P10040.3\|CRB_DROME RecName: Full=Protein crumbs; AltName: Full=95F; Flags: Precursor [NCBI NR] gi\|24649628\|ref\|NP_524480.2\| crumbs, isoform A [Drosophila melanogaster] [NCBI NR] Protein crumbs OS=Drosophila melanogaster GN=crb PE=1 SV=3 [Swiss-Prot] The gene crumbs is referred to in FlyBase by the symbol Dmel\crb (CG6383, FBgn0259685). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20121138..20140165. It has the cytological map location 95F10-95F11. Based on sequence similarity, it is predicted to have molecular function</span>: protein binding. There is experimental evidence for 18 unique biological process</span> terms, many of which group under: anatomical structure development; organ morphogenesis; cell junction organization; cell morphogenesis; positive regulation of cell proliferation; gland morphogenesis; reproductive process in a multicellular organism; maintenance of epithelial cell apical/basal polarity; epithelial cell differentiation; membrane organization; establishment or maintenance of polarity of follicular epithelium; sensory perception of light stimulus. 80 alleles are reported. The phenotypes of these alleles are annotated with 31 unique terms, many of which group under: organ system; external compound sense organ; peripheral nervous system; nervous system; plasma membrane part; primordium; spiracle; adult segment; plasma membrane; embryonic hindgut. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG6383-PA translation from_gene[CG6383 crb FBgn0000368] seq_release:3 mol_weight=233574 cds_boundaries:(3R:20,112,006..20,130,255[+]) aa_length:2146 transcript_info:[CG6383-RA seq_release:3] gene_info:[gene symbol:crb FBgn0000368 gene_boundaries:(3R:2 [hmr_yeast5_DM3-1_pombe.fasta] (Q9VC97) CRB protein [DrosMelano7227.FASTAC.txt] (AE003747) crb gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG6383-PA [Drosophila melanogaster]gi\|24649628\|ref\|NP_524480.2\| CG6383-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3R:join(20121349..20121586,20130923..20131267,20131613..20132605,20133918..20134450,20134747..20135291,20135352..20135457,20135523..20135717,20135783..20136554,20136620..20136802,20136870..20138630,20138699..20138823,20138885..20139298,2 [fly-100309-contam.fasta] CG6383-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Protein crumbs precursor (95F) [nr-271106-contam.fasta] crumbs CG6383-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3R:join(20121349..20121586,20130923..20131267,20131613..20132605,20133918..20134450,20134747..20135291,20135352..20135457,20135523..20135717,20135783..20136554,20136620..20136802,20136870..20138630,20138699..20138823,20138885..20139298,20139371..20139601); ID=FBpp0083987; name=crb-PA; parent=FBgn0259685,FBtr0084603; dbxref=FlyBase:FBpp0083987,FlyBase_Annotation_IDs:CG6383-PA,GB_protein:AAF56276.1,REFSEQ:NP_524480,GB_protein:AAF56276; MD5=59c392d463f25694d5492ded19b1777f; length=2146; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:join(20121349..20121586,20130923..20131267,20131613..20132605,20133918..20134450,20134747..20135291,20135352..20135457,20135523..20135717,20135783..20136554,20136620..20136802,20136870..20138630,20138699..20138823,20138885..20139298,20139371..20139601); ID=FBpp0083987; name=crb-PA; parent=FBgn0259685,FBtr0084603; dbxref=FlyBase:FBpp0083987,FlyBase_Annotation_IDs:CG6383-PA,GB_protein:AAF56276.1,REFSEQ:NP_524480,GB_protein:AAF56276; MD5=59c392d463f25694d5492ded19b1777f; length=2146; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3R:join(20121349..20121586,20130923..20131267,20131613..20132605,20133918..20134450,20134747..20135291,20135352..20135457,20135523..20135717,20135783..20136554,20136620..20136802,20136870..20138630,20138699..20138823,20138885..20139298,20139371..20139601); ID=FBpp0083987; name=crb-PA; parent=FBgn0259685,FBtr0084603; dbxref=FlyBase:FBpp0083987,FlyBase_Annotation_IDs:CG6383-PA,GB_protein:AAF56276.1,REFSEQ:NP_524480,GB_protein:AAF56276,FlyMine:FBpp0083987,modMine:FBpp0083987; MD5=59c392d463f25694d5492ded19b1777f; length=2146; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:join(24295627..24295864,24305201..24305545,24305891..24306883,24308196..24308728,24309025..24309569,24309630..24309735,24309801..24309995,24310061..24310832,24310898..24311080,24311148..24312908,24312977..24313101,24313163..24313576,24313649..24313879); ID=FBpp0083987; name=crb-PA; parent=FBgn0259685,FBtr0084603; dbxref=FlyBase:FBpp0083987,FlyBase_Annotation_IDs:CG6383-PA,GB_protein:AAF56276.1,REFSEQ:NP_524480,GB_protein:AAF56276,FlyMine:FBpp0083987,modMine:FBpp0083987; MD5=59c392d463f25694d5492ded19b1777f; length=2146; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:join(24295627..24295864,24305201..24305545,24305891..24306883,24308196..24308728,24309025..24309569,24309630..24309735,24309801..24309995,24310061..24310832,24310898..24311080,24311148..24312908,24312977..24313101,24313163..24313576,24313649..24313879); ID=FBpp0083987; name=crb-PA; parent=FBgn0259685,FBtr0084603; dbxref=FlyBase:FBpp0083987,FlyBase_Annotation_IDs:CG6383-PA,GB_protein:AAF56276.1,REFSEQ:NP_524480,GB_protein:AAF56276,FlyMine:FBpp0083987,modMine:FBpp0083987; MD5=59c392d463f25694d5492ded19b1777f; length=2146; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0083987 type=protein; loc=3R:join(24295627..24295864,24305201..24305545,24305891..24306883,24308196..24308728,24309025..24309569,24309630..24309735,24309801..24309995,24310061..24310832,24310898..24311080,24311148..24312908,24312977..24313101,24313163..24313576,24313649..24313879); ID=FBpp0083987; name=crb-PA; parent=FBgn0259685,FBtr0084603; dbxref=FlyBase:FBpp0083987,FlyBase_Annotation_IDs:CG6383-PA,GB_protein:AAF56276.1,REFSEQ:NP_524480,GB_protein:AAF56276,FlyMine:FBpp0083987,modMine:FBpp0083987; MD5=59c392d463f25694d5492ded19b1777f; length=2146; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:join(24295627..24295864,24305201..24305545,24305891..24306883,24308196..24308728,24309025..24309569,24309630..24309735,24309801..24309995,24310061..24310832,24310898..24311080,24311148..24312908,24312977..24313101,24313163..24313576,24313649..24313879); ID=FBpp0083987; name=crb-PA; parent=FBgn0259685,FBtr0084603; dbxref=FlyBase:FBpp0083987,FlyBase_Annotation_IDs:CG6383-PA,GB_protein:AAF56276.1,REFSEQ:NP_524480,GB_protein:AAF56276,UniProt/Swiss-Prot:P10040,FlyMine:FBpp0083987,modMine:FBpp0083987; MD5=59c392d463f25694d5492ded19b1777f; length=2146; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2146 amino acids
Gene Ontology:
Cellular Component:	apicolateral plasma membrane [IDA][IPI] subapical complex [TAS] cell-cell adherens junction [NAS] integral to membrane [NAS][TAS] septate junction [TAS] plasma membrane [IDA][ISS] apical plasma membrane [IDA][NAS][TAS]
Biological Process:	establishment or maintenance of apical/basal cell polarity [IMP] adherens junction organization [IMP] positive regulation of cell proliferation [IMP] protein localization [TAS] nervous system development [IMP] salivary gland development [TAS] salivary gland morphogenesis [IMP] maintenance of epithelial cell apical/basal polarity [IDA] establishment or maintenance of epithelial cell apical/basal polarity [NAS][TAS] photoreceptor cell maintenance [IMP][NAS] establishment of epithelial cell apical/basal polarity [IDA][TAS] tube morphogenesis [IMP] establishment or maintenance of polarity of embryonic epithelium [IMP] establishment or maintenance of polarity of follicular epithelium [IMP] cell-cell junction assembly [NAS] establishment or maintenance of cell polarity [IMP][NAS] dorsal closure, amnioserosa morphology change [IMP] zonula adherens maintenance [IMP][NAS] open tracheal system development [IMP] compound eye photoreceptor development [IMP][TAS] oogenesis [IMP] morphogenesis of an epithelium [NAS][TAS] rhabdomere development [IMP][NAS] zonula adherens assembly [IMP][TAS] cellular membrane organization [IMP][TAS] morphogenesis of a polarized epithelium [TAS]
Molecular Function:	protein binding [ISS] spectrin binding [TAS] calcium ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKIANASLS QQQKQRQAET ATTTTTTVAA SVETATTTAR SRDRTKSAAQ ITSHLLKRAI  60
   61 SVYSSPQWIP LFILIYLATD VASVAVPTKE AYFNGSTYLR LTTPMPIWDH SAISFRSCRG 120
  121 GEILAQQYNK NSIVISVLND FLQISLAGPA VHGPNNRLDV KLPYQLLDNR WHTLQFKYEY 180
  181 GNLYLHVDRA ASIFANSTYN SQFLTNQDIG YKDAILILGN SFSGCLLDGP GLQFVNNSTV 240
  241 QNVVFGHCPL TPGPCSDHDL FTRLPDNFCL NDPCMGHGTC SSSPEGYECR CTARYSGKNC 300
  301 QKDNGSPCAK NPCENGGSCL ENSRGDYQCF CDPNHSGQHC ETEVNIHPLC QTNPCLNNGA 360
  361 CVVIGGSGAL TCECPKGYAG ARCEVDTDEC ASQPCQNNGS CIDRINGFSC DCSGTGYTGA 420
  421 FCQTNVDECD KNPCLNGGRC FDTYGWYTCQ CLDGWGGEIC DRPMTCQTQQ CLNGGTCLDK 480
  481 PIGFQCLCPP EYTGELCQIA PSCAQQCPID SECVGGKCVC KPGSSGYNCQ TSTGDGASAL 540
  541 ALTPINCNAT NGKCLNGGTC SMNGTHCYCA VGYSGDRCEK AENCSPLNCQ EPMVCVQNQC 600
  601 LCPENKVCNQ CATQPCQNGG ECVDLPNGDY ECKCTRGWTG RTCGNDVDEC TLHPKICGNG 660
  661 ICKNEKGSYK CYCTPGFTGV HCDSDVDECL SFPCLNGATC HNKINAYECV CQPGYEGENC 720
  721 EVDIDECGSN PCSNGSTCID RINNFTCNCI PGMTGRICDI DIDDCVGDPC LNGGQCIDQL 780
  781 GGFRCDCSGT GYEGENCELN IDECLSNPCT NGAKCLDRVK DYFCDCHNGY KGKNCEQDIN 840
  841 ECESNPCQYN GNCLERSNIT LYQMSRITDL PKVFSQPFSF ENASGYECVC VPGIIGKNCE 900
  901 ININECDSNP CSKHGNCNDG IGTYTCECEP GFEGTHCEIN IDECDRYNPC QRGTCYDQID 960
  961 DYDCDCDANY GGKNCSVLLK GCDQNPCLNG GACLPYLINE VTHLYNCTCE NGFQGDKCEK1020
 1021 TTTLSMVATS LISVTTEREE GYDINLQFRT TLPNGVLAFG TTGEKNEPVS YILELINGRL1080
 1081 NLHSSLLNKW EGVFIGSKLN DSNWHKVFVA INTSHLVLSA NDEQAIFPVG SYETANNSQP1140
 1141 SFPRTYLGGT IPNLKSYLRH LTHQPSAFVG CMQDIMVNGK WIFPDEQDAN ISYTKLENVQ1200
 1201 SGCPRTEQCK PNPCHSNGEC TDLWHTFACH CPRPFFGHTC QHNMTAATFG HENTTHSAVI1260
 1261 VETTDVARRA IRSILDISMF IRTREPTGQV FYLGTDPRKA PTKNIGDSYV AAKLHGGELL1320
 1321 VKMQFSGTPE AYTVGGQKLD NGYNHLIEVV RNQTLVQVKL NGTEYFRKTL STTGLLDAQV1380
 1381 LYLGGPAPTR ESLLGATTEP GIIPVPGAGI PIEDTTVPKE ADDSRDYFKG IIQDVKVSNG1440
 1441 SLNLIVEMYS LNVTDVQVNA KPLGAVTIDR ASVLPGEVSD DLCRKNPCLH NAECRNTWND1500
 1501 YTCKCPNGYK GKNCQEIEFC QHVTCPGQSL CQNLDDGYEC VTNTTFTGQE RSPLAFFYFQ1560
 1561 EQQSDDIVSE ASPKQTLKPV IDIAFRTRAG GTLLYIDNVD GFFEIGVNGG RVTITWKLSA1620
 1621 LHFGESARFE KENTDGEWSR IYLRAHNSKL EGGWKGWESM VDPTPAFSTD IDQAAFQSLI1680
 1681 ATSTQVYLGG MPESRQARGS TLSAQQGSQF KGCVGEARVG DLLLPYFSMA ELYSRTNVSV1740
 1741 QQKAQFRLNA TRPEEGCILC FQSDCKNDGF CQSPSDEYAC TCQPGFEGDD CGTDIDECLN1800
 1801 TECLNNGTCI NQVAAFFCQC QPGFEGQHCE QNIDECADQP CHNGGNCTDL IASYVCDCPE1860
 1861 DYMGPQCDVL KQMTCENEPC RNGSTCQNGF NASTGNNFTC TCVPGFEGPL CDIPFCEITP1920
 1921 CDNGGLCLTT GAVPMCKCSL GYTGRLCEQD INECESNPCQ NGGQCKDLVG RYECDCQGTG1980
 1981 FEGIRCENDI DECNMEGDYC GGLGRCFNKP GSFQCICQKP YCGAYCNFTD PCNATDLCSN2040
 2041 GGRCVESCGA KPDYYCECPE GFAGKNCTAP ITAKEDGPST TDIAIIVIPV VVVLLLIAGA2100
 2101 LLGTFLVMAR NKRATRGTYS PSAQEYCNPR LEMDNVLKPP PEERLI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: crb-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: