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Protein Overview: SMC1-PA

General Information:
Name(s) found: SMC1-PA / FBpp0083926 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene SMC1 is referred to in FlyBase by the symbol Dmel\SMC1 (CG6057, FBgn0040283). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19884024..19888538. It has the cytological map location 95D11. Based on sequence similarity, it is predicted to have molecular function</span>: DNA binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: sister chromatid cohesion. 4 alleles are reported. The phenotype of these alleles is annotated with: condensed chromosome. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1238 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cohesin complex [IDA][ISS][NAS]
    chromosome [IDA]
    Biological Process: sister chromatid cohesion [ISS][NAS]
    negative regulation of gene expression [IGI]
    Molecular Function: DNA binding [ISS]
    ATP binding [IEA]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEEDDDVAQ RVATAPVRKP DDETAFLEYI EMENFKSYRG HIVVGPLKQF NAVIGPNGSG  60
   61 KSNFMDAISF VMGEKTSSLR VKRLNDLIHG SSIGKPVSRS CYVTAKFVLN EERHMDFQRA 120
  121 VIGGSSEYRI NGESVSSSTY LNKLEKIGIN VKAKNFLVFQ GAVENIAMKT PKERTALFEE 180
  181 ISGSGLLKDD YNRLKQEMIV AEEETQFTYQ KKKGIAAERK EAKHEKMEAD RYTRLQNEYN 240
  241 EKQVEYQLFR LFHVERDIRK FTSDLEVRQQ EVKAVEQRKE AADEILREKK KDAGKITRDL 300
  301 AKIDQEIREF ETQMNKRRPL YIKAKEKVTH CKKKLISLQK TLETAREADN AHQSDIRKLE 360
  361 KQLADVEALK KRFEDEIENE SQRRGKSVNM EEGLVQEYDR LKQEAEATAT QYRSELDSVN 420
  421 REQKSEQDTL DGETNRRASV EESFKKLTLQ REEAVKRRDK LMDHIKSSQA ALEEQNRIKD 480
  481 ELRRDVGTSK EKIAEKQREL EDVRDQLGDA KSDKHEDARR KKKQEVVELF KKQVPGVYDR 540
  541 MINMCQPTHK RYNVAVTKVL GKFMEAIIVD TEKTARHCIQ ILKEQMLEVE TFLPLDYLQV 600
  601 KPLKERLRNI SDPRNVRLVF DVLKFEPQEI ERAVLFATGN ALVCETPEDA MKVAYEIDRS 660
  661 RFDALALDGT FYQKSGLISG GSHDLARKAK RWDEKHMAQL KMQKERLQEE LKELVKKSRK 720
  721 QSELATVESQ IKGLENRLKY SMVDLESSKK SISQYDNQLQ QVQSQLDEFG PKILEIERRM 780
  781 QNREEHIQEI KENMNNVEDK VYASFCRRLG VKNIRQYEER ELVMQQERAR KRAEFEQQID 840
  841 SINSQLDFEK QKDTKKNVER WERSVQDEED ALEGLKLAEA RYLKEIDEDK EKMEKFKQDK 900
  901 QAKKQAVDDM EEDISKARKD VANLAKEIHN VGSHLSAVES KIEAKKNERQ NILLQAKTDC 960
  961 IVVPLLRGSL DDAVRQSDPD VPSTSAAMEN IIEVDYSSLP REYTKLKDDS AFKKTHEMLQ1020
 1021 KDLQSKLDVL ERIQTPNMKA LQKLDAVTEK VQSTNEEFEN ARKKAKRAKA AFERVKNERS1080
 1081 SRFVACCQHI SDAIDGIYKK LARNEAAQAY IGPDNPEEPY LDGINYNCVA PGKRFQPMNN1140
 1141 LSGGEKTIAA LALLFSTHSF HPAPFFVLDE IDAALDNTNI GKVASYIRDH TTNLQTIVIS1200
 1201 LKEEFYGHAD ALVGITPGEG DCLVSNVYIM DLTTFEDT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] PSI-BLAST 23.69897 Sc Smc1hd:Scc1-C complex, ATPgS
    2 View Details [95..434] PSI-BLAST 15.221849 Heavy meromyosin subfragment
    3 View Details [435..730] FFAS03 4.35 Smc hinge domain
    4 View Details [731..1090] FFAS03 2.16 Tropomyosin
    5 View Details [1091..1238] PSI-BLAST 15.154902 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.91859588671053 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.23709457794394 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16063754070957 bayes_pls_golite062009
  • DNA binding
    		•  1.10832034923143 bayes_pls_golite062009
  • protein binding
    		•  1.02696508439754 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  1.02239440262162 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.999818859536395 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.558475595998159 bayes_pls_golite062009
  • catalytic activity
    		•  0.265320175609019 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.108132520107784 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle