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Protein Overview: spas-PA, spas-PB

General Information:
Name(s) found: spas-PB / FBpp0083919 [FlyBase]
spas-PA / FBpp0083918 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene spastin is referred to in FlyBase by the symbol Dmel\spas (CG5977, FBgn0039141). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19863940..19868376. It has the cytological map location 95D9. There is experimental evidence that it has the molecular function</span>: ATPase activity. There is experimental evidence that it is involved in the biological process</span>: locomotory behavior; microtubule cytoskeleton organization; positive regulation of microtubule depolymerization. 25 alleles are reported. The phenotypes of these alleles are annotated with: leg; ventral nerve cord; bouton; cytoplasmic microtubule. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene spastin is referred to in FlyBase by the symbol Dmel\spas (CG5977, FBgn0039141). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19863940..19868376. It has the cytological map location 95D9. There is experimental evidence that it has the molecular function</span>: ATPase activity. There is experimental evidence that it is involved in the biological process</span>: locomotory behavior; microtubule cytoskeleton organization; positive regulation of microtubule depolymerization. 25 alleles are reported. The phenotypes of these alleles are annotated with: leg; ventral nerve cord; bouton; cytoplasmic microtubule. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 758 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    terminal button [IDA]
    Biological Process: locomotory behavior [IMP]
    regulation of synaptic plasticity [TAS]
    microtubule cytoskeleton organization [IMP]
    positive regulation of microtubule depolymerization [IDA][IMP]
    transmission of nerve impulse [TAS]
    Molecular Function: ATPase activity [IDA][ISS]
    ATP binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRTKNQSSS SSASSSSTKS PIKSSSGAGS SGGGLGGRQS THRSSSASNV AAVVAGGSSA  60
   61 AGGGSSSNRR SPGSSPDGDD DTTTTDDLTP TTCSPRSGHH HSYGGYSSSV HKQNLYVVSF 120
  121 PIIFLFNVLR SLIYQLFCIF RYLYGASTKV IYRPHRRDCN IEIVVQNSSK EQQQSLNHPS 180
  181 ELNREGDGQE QQLSNQPQRF RPIQPLEMAA NRPGGGYSPG PGDPLLAKQK HHHRRAFEYI 240
  241 SKALKIDEEN EGHKELAIEL YRKGIKELED GIAVDCWSGR GDVWDRAQRL HDKMQTNLSM 300
  301 ARDRLHFLAL REQDLQMQRL SLKEKQKEEA QSKPQKTREP MLAGMTNEPM KLRVRSSGYG 360
  361 PKATTSAQPT ASGRKLTIGS KRPVNLAVAN KSQTLPRNLG SKTSVGAVQR QPAKTAATPP 420
  421 AVRRQFSSGR NTPPQRSRTP INNNGPSGSG ASTPVVSVKG VEQKLVQLIL DEIVEGGAKV 480
  481 EWTDIAGQDV AKQALQEMVI LPSVRPELFT GLRAPAKGLL LFGPPGNGKT LLARAVATEC 540
  541 SATFLNISAA SLTSKYVGDG EKLVRALFAV ARHMQPSIIF IDEVDSLLSE RSSSEHEASR 600
  601 RLKTEFLVEF DGLPGNPDGD RIVVLAATNR PQELDEAALR RFTKRVYVSL PDEQTRELLL 660
  661 NRLLQKQGSP LDTEALRRLA KITDGYSGSD LTALAKDAAL EPIRELNVEQ VKCLDISAMR 720
  721 AITEQDFHSS LKRIRRSVAP QSLNSYEKWS QDYGDITI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] deduced N/A No confident structure predictions are available.
    2 View Details [81..176] PSI-BLAST 6.69897 N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone
    3 View Details [177..758] PSI-BLAST 107.0 VCP/p97


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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