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Protein Overview: CG5933-PA

General Information:
Name(s) found: CG5933-PA / FBpp0083917 [FlyBase]
Description(s) found:
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  • gi|7301087|gb|AAF56221.1| CG5933 [Drosophila melanogaster] [NCBI NR]
  • gi|33301422|sp|Q9VCE6.1|MTA70_DROME RecName: Full=Probable N6-adenosine-methyltransferase MT-A70-like protein [NCBI NR]
  • gi|21355141|ref|NP_651204.1| CG5933 [Drosophila melanogaster] [NCBI NR]
  • gi|21064123|gb|AAM29291.1| AT20169p [Drosophila melanogaster] [NCBI NR]
  • Probable N6-adenosine-methyltransferase MT-A70-like protein OS=Drosophila melanogaster GN=Ime4 PE=2 SV=1 [Swiss-Prot]
  • (Q9VCE6) Probable N6-adenosine-methyltransferase MT-A70-like protein (EC 2.1.1.62) [Swiss-Prot]
  • This gene is referred to in FlyBase by the symbol Dmel\CG5933 (CG5933, FBgn0039139). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19857914..19859979. It has the cytological map location 95D8. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: RNA methylation. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG5933-PA translation from_gene[CG5933 CG5933 FBgn0039139] seq_release:3 mol_weight=68101 cds_boundaries:(3R:19,848,576..19,850,529[+]) aa_length:608 transcript_info:[CG5933-RA seq_release:3] gene_info:[gene symbol:CG5933 FBgn0039139 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003746) CG5933 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5933-PA [Drosophila melanogaster]gi|21064123|gb|AAM29291.1| AT20169p [Drosophila melanogaster]gi|21355141|ref|NP_651204.1| CG5933-PA [Drosophila melanogaster]gi|33301422|sp|Q9VCE6|MT70_DROME Probable N6-adenosine-methyltransferase MT-A70-like protein [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(19857919..19858057,19858120..19858413,19858482..19859875); ID=FBpp0083917; name=CG5933-PA; parent=FBgn0039139,FBtr0084532; dbxref=FlyBase:FBpp0083917,FlyBase_Annotation_IDs:CG5933-PA,GB_protein:AAF56221.1,REFSEQ:NP_651204,GB_prot [fly-100309-contam.fasta]
  • CG5933-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • AT20169p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Probable N6-adenosine-methyltransferase MT-A70-like protein [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(19857919..19858057,19858120..19858413,19858482..19859875); ID=FBpp0083917; name=CG5933-PA; parent=FBgn0039139,FBtr0084532; dbxref=FlyBase:FBpp0083917,FlyBase_Annotation_IDs:CG5933-PA,GB_protein:AAF56221.1,REFSEQ:NP_651204,GB_protein:AAF56221; MD5=0f4ba9eee4e5018cef02cfb216772027; length=608; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(19857919..19858057,19858120..19858413,19858482..19859875); ID=FBpp0083917; name=CG5933-PA; parent=FBgn0039139,FBtr0084532; dbxref=FlyBase:FBpp0083917,FlyBase_Annotation_IDs:CG5933-PA,GB_protein:AAF56221.1,REFSEQ:NP_651204,GB_protein:AAF56221; MD5=0f4ba9eee4e5018cef02cfb216772027; length=608; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Probable N6-adenosine-methyltransferase MT-A70-like protein OS=Drosophila melanogaster GN=CG5933 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(19857919..19858057,19858120..19858413,19858482..19859875); ID=FBpp0083917; name=Ime4-PA; parent=FBgn0039139,FBtr0084532; dbxref=FlyBase:FBpp0083917,FlyBase_Annotation_IDs:CG5933-PA,GB_protein:AAF56221.1,REFSEQ:NP_651204,GB_protein:AAF56221,FlyMine:FBpp0083917,modMine:FBpp0083917; MD5=0f4ba9eee4e5018cef02cfb216772027; length=608; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Probable N6-adenosine-methyltransferase MT-A70-like protein OS=Drosophila melanogaster GN=CG5933 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3R:join(24032197..24032335,24032398..24032691,24032760..24034153); ID=FBpp0083917; name=Ime4-PA; parent=FBgn0039139,FBtr0084532; dbxref=FlyBase:FBpp0083917,FlyBase_Annotation_IDs:CG5933-PA,GB_protein:AAF56221.1,REFSEQ:NP_651204,GB_protein:AAF56221,FlyMine:FBpp0083917,modMine:FBpp0083917; MD5=0f4ba9eee4e5018cef02cfb216772027; length=608; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(24032197..24032335,24032398..24032691,24032760..24034153); ID=FBpp0083917; name=Ime4-PA; parent=FBgn0039139,FBtr0084532; dbxref=FlyBase:FBpp0083917,FlyBase_Annotation_IDs:CG5933-PA,GB_protein:AAF56221.1,REFSEQ:NP_651204,GB_protein:AAF56221,FlyMine:FBpp0083917,modMine:FBpp0083917; MD5=0f4ba9eee4e5018cef02cfb216772027; length=608; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0083917 type=protein; loc=3R:join(24032197..24032335,24032398..24032691,24032760..24034153); ID=FBpp0083917; name=Ime4-PA; parent=FBgn0039139,FBtr0084532; dbxref=FlyBase:FBpp0083917,FlyBase_Annotation_IDs:CG5933-PA,GB_protein:AAF56221.1,REFSEQ:NP_651204,GB_protein:AAF56221,FlyMine:FBpp0083917,modMine:FBpp0083917; MD5=0f4ba9eee4e5018cef02cfb216772027; length=608; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(24032197..24032335,24032398..24032691,24032760..24034153); ID=FBpp0083917; name=Ime4-PA; parent=FBgn0039139,FBtr0084532; dbxref=FlyBase:FBpp0083917,FlyBase_Annotation_IDs:CG5933-PA,GB_protein:AAF56221.1,REFSEQ:NP_651204,GB_protein:AAF56221,UniProt/Swiss-Prot:Q9VCE6,FlyMine:FBpp0083917,modMine:FBpp0083917; MD5=0f4ba9eee4e5018cef02cfb216772027; length=608; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 608 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: RNA methylation [ISS]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    Molecular Function: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADAWDIKSL KTKRNTLREK LEKRKKERIE ILSDIQEDLT NPKKELVEAD LEVQKEVLQA  60
   61 LSSCSLALPI VSTQVVEKIA GSSLEMVNFI LGKLANQGAI VIRNVTIGTE AGCEIISVQP 120
  121 KELKEILEDT NDTCQQKEEE AKRKLEVDDV DQPQEKTIKL ESTVARKEST SLDAPDDIMM 180
  181 LLSMPSTREK QSKQVGEEIL ELLTKPTAKE RSVAEKFKSH GGAQVMEFCS HGTKVECLKA 240
  241 QQATAEMAAK KKQERRDEKE LRPDVDAGEN VTGKVPKTES AAEDGEIIAE VINNCEAESQ 300
  301 ESTDGSDTCS SETTDKCTKL HFKKIIQAHT DESLGDCSFL NTCFHMATCK YVHYEVDTLP 360
  361 HINTNKPTDV KTKLSLKRSV DSSCTLYPPQ WIQCDLRFLD MTVLGKFAVV MADPPWDIHM 420
  421 ELPYGTMSDD EMRALGVPAL QDDGLIFLWV TGRAMELGRD CLKLWGYERV DELIWVKTNQ 480
  481 LQRIIRTGRT GHWLNHGKEH CLVGMKGNPT NLNRGLDCDV IVAEVRATSH KPDEIYGIIE 540
  541 RLSPGTRKIE LFGRPHNIQP NWITLGNQLD GIRLVDPELI TQFQKRYPDG NCMSPASANA 600
  601 ASINGIQK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..348] PSI-BLAST 16.69897 Heavy meromyosin subfragment
    2 View Details [349..608] FFAS03 1.21 m.RsrI N6 adenosine-specific DNA methyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • methyltransferase activity
    		•  3.68431317301075 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.64494850793256 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  3.60853685152199 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.51986359093355 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  3.27333514131005 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.91374296950366 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.666651371662 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  2.63941856307703 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  1.99340565364513 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  1.99340565364513 bayes_pls_golite062009
  • transferase activity
    		•  1.97261773840408 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  1.85380504590369 bayes_pls_golite062009
  • binding
    		•  1.65046086869658 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  1.64765900536818 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.59599828300594 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  1.5743030926483 bayes_pls_golite062009
  • DNA binding
    		•  1.48691268044769 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.38914410921124 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.36595590938226 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.27753381141602 bayes_pls_golite062009
  • DNA (cytosine-5-)-methyltransferase activity
    		•  1.23915163423518 bayes_pls_golite062009
  • catalytic activity
    		•  1.16970557486814 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  0.862671287243863 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  0.735680462496249 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.51222176401398 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  0.325961687103877 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  0.325961687103877 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.283627597838594 bayes_pls_golite062009
  • histone binding
    		•  0.230289474831554 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.113328595762489 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.0390774859535424 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle