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Protein Overview: Irk2-PA

General Information:
Name(s) found: Irk2-PA / FBpp0083817 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Inwardly rectifying potassium channel 2 is referred to in FlyBase by the symbol Dmel\Irk2 (CG4370, FBgn0039081). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19339690..19345167. It has the cytological map location 95A1. There is experimental evidence that it has the molecular function</span>: inward rectifier potassium channel activity. There is experimental evidence that it is involved in the biological process</span>: potassium ion transport; regulation of membrane potential. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 453 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IDA]
    Biological Process: potassium ion transport [IDA]
    regulation of membrane potential [IDA]
    Molecular Function: G-protein activated inward rectifier potassium channel activity [ISS]
    inward rectifier potassium channel activity [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFNFSTHSA APTSTTIPTT TQANGGEQAT QPLKKAIEAD PDSLDSVISN PQSYPITIVP  60
   61 NRPTSYYGLS QNGKPFPRQP SCRSRNFRPG SMRRVRRRAV FKNGDCNVVQ KHLQRRRVRF 120
  121 LQDMYTTMVD WQWRWTLLAF ALSFILSWLF FALIWWLIIY THGDLEEPHL PENQEESGWA 180
  181 PCVSAIDGFT SCFLFSIETQ HTIGYGVRTT SPECPEAIFM MCFQSIYGVM SSAFMAGIVF 240
  241 AKMTRAKQRA QTLLFSKHAV ICQRDGTLSL MFRVGDMRKS HIIGAGVRAQ LIRTKSTKEG 300
  301 EVMTQYFTEL EIGTDDSGSD LFFIWPMVIE HKIDENSPLY NLNATDMLQD KFEIVVILEG 360
  361 TVESTGQSTQ ARSSYINTEI LWGHRFDPVV LYNKDLQAYE IDYARFNETT QVDTPLCSAR 420
  421 ELNEIYKIQE GFRTPETTFT MRQLSHNHSD QAS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] deduced N/A No confident structure predictions are available.
    2 View Details [90..453] PSI-BLAST 93.221849 No description for 2qksA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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