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Protein Overview: FBpp0306672, Gclm-PA

General Information:
Name(s) found: FBpp0306672 [FlyBase]
Gclm-PA / FBpp0083729 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=3R:complement(18511215..18512072); ID=FBpp0306672; name=Gclm-PB; parent=FBgn0046114,FBtr0334605; dbxref=FlyBase:FBpp0306672,FlyBase_Annotation_IDs:CG4919-PB,REFSEQ:NP_001262845,GB_protein:AGB96225; MD5=2cc1a6d1c7be88f4f71b714c5704bd2a; length=285; release=r5.56; species=Dmel; [FlyBase]
  • The gene Glutamate-cysteine ligase modifier subunit is referred to in FlyBase by the symbol Dmel\Gclm (CG4919, FBgn0046114). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18511022..18512249. It has the cytological map location 94C1. There is experimental evidence that it has the molecular function</span>: glutamate-cysteine ligase catalytic subunit binding; enzyme binding; enzyme regulator activity. There is experimental evidence that it is involved in the biological process</span>: olfactory learning; cellular response to DNA damage stimulus; learning or memory; glutathione biosynthetic process; positive regulation of glutamate-cysteine ligase activity. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 285 amino acids

    Gene Ontology:
    Cellular Component: glutamate-cysteine ligase complex [IPI]
    cytosol [IDA]
    Biological Process: glutathione biosynthetic process [IDA][IMP]
    positive regulation of glutamate-cysteine ligase activity [IDA]
    olfactory learning [IMP]
    oxidation reduction [IEA]
    response to DNA damage stimulus [IMP]
    learning or memory [IMP]
    Molecular Function: oxidoreductase activity [IEA]
    enzyme regulator activity [IDA]
    glutamate-cysteine ligase catalytic subunit binding [IPI]
    enzyme binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIPTITKKYQ NVVISTGNII ATELGQRKSN EELYDGLKIT LHTDSTAERV VVEKEIDELH  60
   61 GRVQRATQEL TTRLTENGRN EISIGAKIFL NRHSTESVNQ AVEELLHILS VTHVDNVVLA 120
  121 YHPNAVATAT PVATTKPPCS EDSNVSRATN WSQRNGKEGV AELKELYKTL EQYALKQQIT 180
  181 QLGIADLDAA ALEELHNSAQ VVPTIAQVNL STCCVVPPEL QEFCTAHDIQ LNTHSDPELL 240
  241 LPVEQFDGLV PGYTIDWTLR YQVHVRCRGV LTAKGYIVGA SRSSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..285] PSI-BLAST 67.69897 Binary complex of rabbit 20alpha-hydroxysteroid dehydrogenase with NADPH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  1.98742533821796 bayes_pls_golite062009
  • catalytic activity
    		•  1.68179794468736 bayes_pls_golite062009
  • aldo-keto reductase activity
    		•  1.47086393545449 bayes_pls_golite062009
  • aldehyde reductase activity
    		•  0.871569797178902 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.868027162240181 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.86591084281532 bayes_pls_golite062009
  • binding
    		•  0.664561857863194 bayes_pls_golite062009
  • protein binding
    		•  0.013141318464947 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle