YRC Public Data Repository - Protein Structure Prediction

Protein:	FBpp0306672, Gclm-PA
Organism:	Drosophila melanogaster
Length:	285 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0306672, Gclm-PA.

Description	E-value	Query Range	Subject Range
gi\|91076408 - gi\|91076408\|ref\|XP_969456.1\| PREDICTED: similar to CG6084 CG6084-PA [Tribolium castaneum]	258.0	[0..6]	[284..10]
gi\|118403930, gi... - gi\|118403930\|ref\|NP_001072181.1\| 3-alpha-hydroxysteroid dehydrogenase [Xenopus (Silurana) tropicalis...	256.0	[0..5]	[284..11]
DHB5_MOUSE - Estradiol 17 beta-dehydrogenase 5 OS=Mus musculus GN=Akr1c6 PE=1 SV=1	256.0	[0..5]	[283..10]
gi\|15208400 - gi\|15208400\|dbj\|BAB63207.1\| 3(20)alpha-hydroxysteroid/dihydrodiol/indanol dehydrogenase [Macaca fusc... AK1C1_MACFU - Aldo-keto reductase family 1 member C1 homolog OS=Macaca fuscata fuscata GN=AKR1C1 PE=2 SV=1 gi\|109088079, gi... - gi\|109088083\|ref\|XP_001103887.1\| PREDICTED: aldo-keto reductase family 1, member C1 isoform 5 [Macac...	255.0	[0..5]	[283..10]
gi\|108880318, gi... - gi\|157104536\|ref\|XP_001648454.1\| aldo-keto reductase [Aedes aegypti], gi\|108880318\|gb\|EAT44543.1\| al...	255.0	[0..1]	[284..7]
gi\|118777462, gi... - gi\|118777462\|ref\|XP_308086.3\| AGAP011050-PA [Anopheles gambiae str. PEST], gi\|116132724\|gb\|EAA45511.... AGAP011050-PA - aldehyde reductase\|protein_coding\|3L:15774210:15776890:-1\|gene:AGAP011050	254.0	[0..4]	[284..9]
PE2R_RABIT - Prostaglandin-E(2) 9-reductase OS=Oryctolagus cuniculus GN=AKR1C5 PE=1 SV=1	254.0	[0..5]	[283..10]

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Predicted Domain #1

Region A:
Residues: [1-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIPTITKKYQ NVVISTGNII ATELGQRKSN EELYDGLKIT LHTDSTAERV VVEKEIDELH  60
   61 GRVQRATQEL TTRLTENGRN EISIGAKIFL NRHSTESVNQ AVEELLHILS VTHVDNVVLA 120
  121 YHPNAVATAT PVATTKPPCS EDSNVSRATN WSQRNGKEGV AELKELYKTL EQYALKQQIT 180
  181 QLGIADLDAA ALEELHNSAQ VVPTIAQVNL STCCVVPPEL QEFCTAHDIQ LNTHSDPELL 240
  241 LPVEQFDGLV PGYTIDWTLR YQVHVRCRGV LTAKGYIVGA SRSSV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.69897
Match:	1q5mA
Description:	Binary complex of rabbit 20alpha-hydroxysteroid dehydrogenase with NADPH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	1.98742533821796	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
aldo-keto reductase activity	1.47086393545449	bayes_pls_golite062009
aldehyde reductase activity	0.871569797178902	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.868027162240181	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.86591084281532	bayes_pls_golite062009
binding	0.664561857863194	bayes_pls_golite062009
protein binding	0.013141318464947	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: