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Protein Overview: loco-PB

General Information:
Name(s) found: loco-PB / FBpp0083668 [FlyBase]
Description(s) found:
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  • gi|7300892|gb|AAF56033.1| locomotion defects, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|24649091|ref|NP_732775.1| locomotion defects, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene locomotion defects is referred to in FlyBase by the symbol Dmel\loco (CG5248, FBgn0020278). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18445690..18465082. It has the cytological map location 94B6-94B8. There is experimental evidence that it has the molecular function</span>: G-protein alpha-subunit binding; GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of G-protein coupled receptor protein signaling pathway; glial cell differentiation; asymmetric neuroblast division; asymmetric protein localization; dorsal/ventral axis specification, ovarian follicular epithelium; establishment of glial blood-brain barrier; cytoplasmic transport, nurse cell to oocyte; cortical actin cytoskeleton organization; septate junction assembly; ventral cord development. 34 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; yolk; embryonic head; embryonic glial cell; neuroblast; embryonic midgut; egg; longitudinal connective; embryonic foregut; dorsal appendage. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG5248-PB translation from_gene[CG5248 loco FBgn0020278] seq_release:3 mol_weight=129705 cds_boundaries:(3R:18,436,674..18,446,971[-]) aa_length:1175 transcript_info:[CG5248-RB seq_release:3] gene_info:[gene symbol:loco synonyms:[CG17229] FBgn0020278 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VCX2) LOCO protein [DrosMelano7227.FASTAC.txt]
  • (AE003739) loco gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5248-PB, isoform B [Drosophila melanogaster]gi|24649091|ref|NP_732775.1| CG5248-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(18446015..18446577,18446645..18447785,18447846..18448628,18455275..18456315); ID=FBpp0083668; name=loco-PB; parent=FBgn0020278,FBtr0084275; dbxref=FlyBase:FBpp0083668,FlyBase_Annotation_IDs:CG5248-PB,GB_protein:AAF56033.1,R [fly-100309-contam.fasta]
  • CG5248-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • locomotion defects CG5248-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(18446015..18446577,18446645..18447785,18447846..18448628,18455275..18456315); ID=FBpp0083668; name=loco-PB; parent=FBgn0020278,FBtr0084275; dbxref=FlyBase:FBpp0083668,FlyBase_Annotation_IDs:CG5248-PB,GB_protein:AAF56033.1,REFSEQ:NP_732775,GB_protein:AAF56033; MD5=2ac33e1120bda8ed788ac91f49da4d6d; length=1175; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(18446015..18446577,18446645..18447785,18447846..18448628,18455275..18456315); ID=FBpp0083668; name=loco-PB; parent=FBgn0020278,FBtr0084275; dbxref=FlyBase:FBpp0083668,FlyBase_Annotation_IDs:CG5248-PB,GB_protein:AAF56033.1,REFSEQ:NP_732775,GB_protein:AAF56033; MD5=2ac33e1120bda8ed788ac91f49da4d6d; length=1175; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Locomotion defects, isoform B OS=Drosophila melanogaster GN=loco PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(18446015..18446577,18446645..18447785,18447846..18448628,18455275..18456315); ID=FBpp0083668; name=loco-PB; parent=FBgn0020278,FBtr0084275; dbxref=FlyBase:FBpp0083668,FlyBase_Annotation_IDs:CG5248-PB,GB_protein:AAF56033.1,REFSEQ:NP_732775,GB_protein:AAF56033,FlyMine:FBpp0083668,modMine:FBpp0083668; MD5=2ac33e1120bda8ed788ac91f49da4d6d; length=1175; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(22629553..22630593,22622124..22622906,22620923..22622063,22620293..22620855)); ID=FBpp0083668; name=loco-PB; parent=FBgn0020278,FBtr0084275; dbxref=FlyBase:FBpp0083668,FlyBase_Annotation_IDs:CG5248-PB,GB_protein:AAF56033.1,REFSEQ:NP_732775,GB_protein:AAF56033,FlyMine:FBpp0083668,modMine:FBpp0083668; MD5=2ac33e1120bda8ed788ac91f49da4d6d; length=1175; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(22629553..22630593,22622124..22622906,22620923..22622063,22620293..22620855)); ID=FBpp0083668; name=loco-PB; parent=FBgn0020278,FBtr0084275; dbxref=FlyBase:FBpp0083668,FlyBase_Annotation_IDs:CG5248-PB,GB_protein:AAF56033.1,REFSEQ:NP_732775,GB_protein:AAF56033,FlyMine:FBpp0083668,modMine:FBpp0083668; MD5=2ac33e1120bda8ed788ac91f49da4d6d; length=1175; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9VCX1, Locomotion defects, isoform B OS=Drosophila melanogaster GN=loco PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0083668 type=protein; loc=3R:complement(join(22629553..22630593,22622124..22622906,22620923..22622063,22620293..22620855)); ID=FBpp0083668; name=loco-PB; parent=FBgn0020278,FBtr0084275; dbxref=FlyBase:FBpp0083668,FlyBase_Annotation_IDs:CG5248-PB,GB_protein:AAF56033.1,REFSEQ:NP_732775,GB_protein:AAF56033,FlyMine:FBpp0083668,modMine:FBpp0083668; MD5=2ac33e1120bda8ed788ac91f49da4d6d; length=1175; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(22629553..22630593,22622124..22622906,22620923..22622063,22620293..22620855)); ID=FBpp0083668; name=loco-PB; parent=FBgn0020278,FBtr0084275; dbxref=FlyBase:FBpp0083668,FlyBase_Annotation_IDs:CG5248-PB,GB_protein:AAF56033.1,REFSEQ:NP_732775,GB_protein:AAF56033,UniProt/TrEMBL:Q9VCX2,FlyMine:FBpp0083668,modMine:FBpp0083668; MD5=2ac33e1120bda8ed788ac91f49da4d6d; length=1175; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1175 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    apical cortex [IDA]
    plasma membrane [IDA]
    Biological Process: cortical actin cytoskeleton organization [IMP]
    ventral cord development [IMP]
    septate junction assembly [IMP]
    dorsal/ventral axis specification, ovarian follicular epithelium [IMP]
    asymmetric neuroblast division [IMP]
    establishment of glial blood-brain barrier [IMP]
    regulation of G-protein coupled receptor protein signaling pathway [IGI][NAS]
    glial cell differentiation [IMP]
    cytoplasmic transport, nurse cell to oocyte [IMP]
    asymmetric protein localization [IMP]
    Molecular Function: G-protein alpha-subunit binding [IPI]
    GTPase activator activity [IDA]
    receptor signaling protein activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNTNTTRGT CSRIPIASKQ EPTIASMVER FVQSLSQLND SGTFDSSFEI KRIHPGSSAG  60
   61 STPKHVRHRC LTELDREQLT RFVQDFEERQ ASTPKVKSKI SSPYICRKAK EFYQSASGRR 120
  121 SASPQITIAP ETVQEEKVLV NPLPRKCAEA EDLMPPPMAM ARVQAERRSC RSASRVLQFF 180
  181 SSATKRRSGN RKLSEPEMED NRADSPVLIR VTRDRVEEQL GCSPLAASGG EVPTSSEDEE 240
  241 EHDDGISSAS SNLTSQSGSS NSRNLSPDSS FEMHAPLLPS FKVTPPRAVC RVGKNAACEF 300
  301 ARFLRGSFHS KRASVTTLRR SLSDPDAVQQ MDFSKPPPLR DTTNVMRNRA LPANASPFRR 360
  361 AWGQSSFRTP RSDKVAKEQQ QLGQSSPVRR TASMNASDND MYIKTLMLDS DLKSSRSQHQ 420
  421 LSLLQVPKVL TTPAPPSAIT ASVAAEGAAQ DHGCPSSWAG SFERMLQDAA GMQTFSEFLK 480
  481 KEFSAENIYF WTACERYRLL ESEADRVAQA REIFAKHLAN NSSDPVNVDS QARSLTEEKL 540
  541 ADAAPDIFAP AQKQIFSLMK FDSYQRFIRS DLYKSCVEAE QKNQPLPYSG LDLDELLKTN 600
  601 FHLGAFSKLK KSASNAEDRR RKSLLPWHRK TRSKSRDRTE IMADMQHALM PAPPVPQNAP 660
  661 LTSASLKLVC GQNSLSDLHS SRSSLSSFDA GTATGGQGAS TESVYSLCRV ILTDGATTIV 720
  721 QTRPGETVGE LVERLLEKRN LVYPYYDIVF QGSTKSIDVQ QPSQILAGKE VVIERRVAFK 780
  781 LDLPDPKVIS VKSKPKKQLH EVIRPILSKY NYKMEQVQVI MRDTQVPIDL NQPVTMADGQ 840
  841 RLRIVMVNSD FQVGGGSSMP PKQSKPMKPL PQGHLDELTN KVFNELLASK ADAAASEKSR 900
  901 PVDLCSMKSN EAPSETSSLF ERMRRQQRDG GNIPASKLPK LKKKSTSSSQ QSEEAATTQA 960
  961 VADPKKPIIA KLKAGVKLQV TERVAEHQDE LLEGLKRAQL ARLEDQRGTE INFDLPDFLK1020
 1021 NKENLSAAVS KLRKVRASLS PVSKVPATPT EIPQPAPRLS ITRSQQPVSP MKVDQEPETD1080
 1081 LPAATQDQTE FAKAPPPLPP KPKVLPIKPS NWGVAQPTGN YCNKYSPSKQ VPTSPKEASK1140
 1141 PGTFASKIPL DLGRKSLEEA GSRCAYLDEP SSSFV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] deduced N/A No confident structure predictions are available.
    2 View Details [191..396] deduced N/A No confident structure predictions are available.
    3 View Details [397..600] PSI-BLAST 56.69897 Regulator of G-protein signalling 4, RGS4
    4 View Details [601..690] deduced N/A No confident structure predictions are available.
    5 View Details [691..779] FFAS03 3.7 THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
    6 View Details [780..881] PSI-BLAST 16.69897 Solution structure of the Ras-binding domain of mouse RGS14
    7 View Details [882..1082] PSI-BLAST 13.522879 RBP1
    8 View Details [1083..1175] PSI-BLAST 4.09691 Fibrinogen

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • GTPase regulator activity
    		•  1.92987277493861 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.90800479999702 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.87534424848905 bayes_pls_golite062009
  • binding
    		•  1.71250041369331 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.62073651679221 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.49796137854909 bayes_pls_golite062009
  • protein binding
    		•  1.34804002381061 bayes_pls_golite062009
  • signal transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.59248827140739 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.28306198153429 bayes_pls_golite062009
  • binding
    		•  2.0688320293797 bayes_pls_golite062009
  • protein binding
    		•  1.72968950672856 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07208466109379 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07208466109379 bayes_pls_golite062009
  • receptor binding
    		•  0.286966350616338 bayes_pls_golite062009
    6
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.3713276381973 bayes_pls_golite062009
  • binding
    		•  2.14676646738549 bayes_pls_golite062009
  • protein binding
    		•  1.86841453215444 bayes_pls_golite062009
  • signal transducer activity
    		•  1.05682194741929 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.05682194741929 bayes_pls_golite062009
  • receptor binding
    		•  0.298046142314417 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle