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Protein Overview: burs-PA

General Information:
Name(s) found: burs-PA / FBpp0083529 [FlyBase]
Description(s) found:
Found 52 descriptions.
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  • The gene bursicon is referred to in FlyBase by the symbol Dmel\burs (CG13419, FBgn0038901). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17595273..17595916. It has the cytological map location 93F9. There is experimental evidence that it has the molecular function</span>: hormone activity. There is experimental evidence that it is involved in the biological process</span>: cuticle pigmentation; chitin-based cuticle tanning; regulation of adult chitin-containing cuticle pigmentation; imaginal disc-derived wing morphogenesis. 9 alleles are reported. The phenotypes of these alleles are annotated with: adult thorax; adult cuticle; adult abdomen; wing; posterior scutellar bristle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 173 amino acids

    Gene Ontology:
    Cellular Component: bursicon neuropeptide hormone complex [IDA]
    extracellular region [IDA]
    Biological Process: cuticle pigmentation [IMP]
    chitin-based cuticle tanning [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    regulation of chitin-based cuticle tanning [NAS]
    regulation of adult chitin-containing cuticle pigmentation [IMP]
    Molecular Function: neuropeptide hormone activity [IC][NAS]
    hormone activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRHLLRHEN NKVFVLILLY CVLVSILKLC TAQPDSSVAA TDNDITHLGD DCQVTPVIHV  60
   61 LQYPGCVPKP IPSFACVGRC ASYIQVSGSK IWQMERSCMC CQESGEREAA VSLFCPKVKP 120
  121 GERKFKKVLT KAPLECMCRP CTSIEESGII PQEIAGYSDE GPLNNHFRRI ALQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] FFAS03 1.82 Gonadotropin B chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • receptor binding
    		•  3.35996116486789 bayes_pls_golite062009
  • cytokine activity
    		•  2.73712874200453 bayes_pls_golite062009
  • growth factor activity
    		•  2.6160729614164 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  2.34325173014763 bayes_pls_golite062009
  • binding
    		•  2.05370202030285 bayes_pls_golite062009
  • protein binding
    		•  1.82386610100131 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.79811530491169 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.79811530491169 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.67510105131784 bayes_pls_golite062009
  • cell surface binding
    		•  1.66674781438071 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  1.53869600764493 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  1.52326054173375 bayes_pls_golite062009
  • heparin binding
    		•  1.23772590555078 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  1.13171867198032 bayes_pls_golite062009
  • growth factor binding
    		•  1.03019655218593 bayes_pls_golite062009
  • hormone activity
    		•  1.02692930083275 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.999976313378305 bayes_pls_golite062009
  • pattern binding
    		•  0.777498464123891 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  0.670059401770955 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  0.605794301244184 bayes_pls_golite062009
  • identical protein binding
    		•  0.598427754086431 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.139996982599169 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.129103245482061 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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