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Protein Overview: Hs6st-PA, FBpp03...

General Information:
Name(s) found: FBpp0307227 [FlyBase]
Hs6st-PA / FBpp0083255 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=3R:complement(15756119..15756254,15762976..15763160,15763224..15763772,15763846..15764178,15831957..15832142); ID=FBpp0307227; name=Hs6st-PB; parent=FBgn0038755,FBtr0335240; dbxref=REFSEQ:NP_001262750,GB_protein:AGB96130,FlyBase:FBpp0307227,FlyBase_Annotation_IDs:CG4451-PB; MD5=66e69cacbb46f34fab31ed01cf80b865; length=462; release=r5.56; species=Dmel; [FlyBase]
  • The gene Heparan sulfate 6-O-sulfotransferase is referred to in FlyBase by the symbol Dmel\Hs6st (CG4451, FBgn0038755). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15755436..15834244. It has the cytological map location 92B9-92C1. It is reported to have molecular function</span>: heparan sulfate 6-O-sulfotransferase activity. There is experimental evidence that it is involved in the biological process</span>: open tracheal system development. 20 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval lateral trunk; eye; embryonic/larval trachea; embryonic/larval dorsal trunk; embryonic tracheal system; embryonic/larval tracheal system; imaginal tracheoblast; embryonic/larval dorsal branch. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 462 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEA]
    Biological Process: primary branching, open tracheal system [TAS]
    heparan sulfate proteoglycan biosynthetic process [TAS]
    carbohydrate biosynthetic process [IEA]
    fibroblast growth factor receptor signaling pathway [TAS]
    open tracheal system development [IGI][IMP]
    Molecular Function: heparan sulfate 6-O-sulfotransferase activity [NAS]
    sulfotransferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGDMHKNVS VQVDSDFALL LPSGVYEIKK MEPRSKIRTI IVFCLFLAIA GIIGFGYFCQ  60
   61 DQVCALSKRA VILQSSDILA YNELPLHQAN SINGNANGNS NGNGNSVGGI TAMASKSSAP 120
  121 QNIIANAGLS YEDVLNDDFQ FDMDGHDVMV FLHIQKTGGT SFGRHLVRDL DLKRPCECQR 180
  181 QRKRCYCFRP HRNENWLFSR YSTGWKCGLH ADWTELTSCV DVELDKNEGE TAKRRYFYIS 240
  241 LLRQPIARYM SEYRHVRRGA TWKGSRHWCL GRQATAAELP ACYKGKDWLD VDLDQFAGCE 300
  301 SNLAANRQTR MLADLALVGC YNKSSMPAHE RDRVMLASAK RNLAAMAYFG LTEYQKMSQY 360
  361 IFEETFNLRF AIPFEQHNTT ISATAVQNLR PDQKRRIEKL NSLDIELYAF AKTLLFQRFE 420
  421 HLKAKDTNFE QRYANLGNIY FKQGVTEFNW DSNVEDGLST DH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] deduced N/A No confident structure predictions are available.
    2 View Details [143..308] PSI-BLAST 3.522879 Aryl sulfotransferase sult1a3
    3 View Details [309..462] MSA 5.169989 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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