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Protein Overview: bnl-PA

General Information:
Name(s) found: bnl-PA / FBpp0083206 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene branchless is referred to in FlyBase by the symbol Dmel\bnl (CG4608, FBgn0014135). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15619795..15662539. It has the cytological map location 92B2-92B3. Based on sequence similarity, it is predicted to have molecular function</span>: fibroblast growth factor receptor binding. There is experimental evidence that it is involved in the biological process</span>: filopodium assembly; cytoneme assembly; positive chemotaxis; genital disc development; open tracheal system development. 20 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; embryonic/larval tracheal system; portion of tissue; tracheal system; trachea; embryonic/larval dorsal branch; adult trachea; embryonic tracheal system; primordium; embryonic ganglionic branch. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 770 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [ISS]
    Biological Process: cytoneme assembly [IDA]
    positive chemotaxis [IDA][TAS]
    regulation of tube architecture, open tracheal system [TAS]
    fibroblast growth factor receptor signaling pathway [NAS][TAS]
    terminal branching, open tracheal system [TAS]
    filopodium assembly [IMP]
    tracheal outgrowth, open tracheal system [TAS]
    open tracheal system development [IMP][NAS][TAS]
    secondary branching, open tracheal system [TAS]
    chemotaxis [TAS]
    morphogenesis of a branching structure [TAS]
    epithelial cell migration, open tracheal system [TAS]
    primary branching, open tracheal system [TAS]
    genital disc development [IEP]
    Molecular Function: growth factor activity [IEA]
    fibroblast growth factor receptor binding [ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRNLRLDWR ALALLGALLS FIIAWRGLVS AMPLMAMDNN LTDSSGSTNT STSSTSKYNS  60
   61 TNNSNLFSNS YLQSDHSRSS LVPSAVSERS VNQPTNQSIN AEFNQSLSTH PTAITSTPQT 120
  121 QTQTQIQSQY PSQAEDSDQL EEPLGFVISA MPNEHLAVLS RTERSIRHQN QQQQKKHHHH 180
  181 HQQQQQQQHQ QQQPMSPADN NFIGSKSKRL SNPRSSLNIN SSSSNTPISN LDRNERSTVP 240
  241 QSHLAWTSRK IQLYIKNRIL QILRDGVVNG TQDENSEFTI LQRSTVDVGR IKLQSVATCL 300
  301 YLCMDACGVP YGSKDFTDDC VFNENMGLQN YNTYSSTYHS QARRVFYLAL NGSGQPRRTQ 360
  361 IPASRSLGKL STYTNAITET VPQERVEQLI AKNFGANRVK HGVRQLCDTG KPLIELIDVA 420
  421 RFKAPPHCSS NTSGSSSSIS SSSSSSSKSS SNSSSSYVPV SAISSLSSIS NSSQSESGHI 480
  481 SSSLSGSSNS NSSSNSSSSN SSSNSSRPSG SKANKKKKPK CKPHEQEDTH NCQKRGGAGA 540
  541 GALRKLGPKA KRCKELREKA AAEKRAPPNC GKKNGARKNP TEAAKAVQQR PKGNIQHGGK 600
  601 KKPNKAGKQR QNGGKKQQQQ QQHQLQQQPL QHQAKSISGG KRKHRKLDAS TTTTMATSLG 660
  661 TPPSSHWESS SPLPAFSLSE TSDRVERNVR MSSGEEQDQD NDQDQEQSDP GEQGEEETEG 720
  721 DGGSLEDASY EDSSSEAQGR SGAGGDDSLY YDFLCLQLIA MVLLRKRAIL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..202] FFAS03 1.24 Solution structure of SelM from Mus musculus
    2 View Details [203..389] PSI-BLAST 48.30103 Fibroblast growth factor 9, FGF9
    3 View Details [390..532] deduced N/A No confident structure predictions are available.
    4 View Details [533..770] MSA 2.203996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  0.116617745968569 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  0.207885057641751 bayes_pls_golite062009
  • protein binding
    		•  0.11345320970064 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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