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Protein Overview: Ppcs-PA

General Information:
Name(s) found: Ppcs-PA / FBpp0083166 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • The gene Phosphopantothenoylcysteine synthetase is referred to in FlyBase by the symbol Dmel\Ppcs (CG5629, FBgn0261285). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14964788..14973629. It has the cytological map location 91F3-91F4. Based on sequence similarity, it is predicted to have molecular function</span>: phosphopantothenate--cysteine ligase activity. There is experimental evidence that it is involved in the biological process</span>: bristle development; triglyceride homeostasis; actin cytoskeleton organization; germarium-derived female germ-line cyst encapsulation; ovarian follicle cell stalk formation; phospholipid homeostasis; cytoplasmic transport, nurse cell to oocyte; imaginal disc-derived wing morphogenesis; ovarian follicle cell migration; dorsal appendage formation. 19 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system; female germline cyst; anatomical structure; nervous system; germarium; cytoplasmic part; adult brain; external compound sense organ; adult segment; adult. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 313 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: ovarian follicle cell stalk formation [IMP]
    ovarian follicle cell migration [IMP]
    coenzyme A biosynthetic process [UNKNOWN]
    imaginal disc-derived wing morphogenesis [IMP]
    dorsal appendage formation [IMP]
    germarium-derived female germ-line cyst encapsulation [IMP]
    bristle development [IMP]
    triglyceride homeostasis [IMP]
    actin cytoskeleton organization [IMP]
    phospholipid homeostasis [IMP]
    cytoplasmic transport, nurse cell to oocyte [IMP]
    Molecular Function: phosphopantothenate--cysteine ligase activity [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHWEDFYNT HLPPADFEDN RSLLKEFCER HNKLQNRIVL VTSGGTTVPL EHNTVRFVDN  60
   61 FSAGTRGSAS AEYFLDHDYA VIFMHRHKSL EPFTRHFTGQ QFFDMLDIAD NSQSSTIAIK 120
  121 PDSVDVFAPV LAKYKIARET QMILYVNFTS VVDYMWLLRA ACECLAAFEE RAVLYLAAAV 180
  181 SDFYIPEDMM PTHKMQSGDG APTISLQLVP KMLAPLASLW VPHAFVVSFK LETDESLLIV 240
  241 KARDSLNKYK HKLVIANVLQ TRKHRVVFVT PTDSYELHLT REQTLQGLEI EEPIVADVVQ 300
  301 KHGEFISNAQ QRQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..313] PSI-BLAST 76.69897 Crystal Structure of Phosphopantothenoylcysteine Synthetase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphopantothenate--cysteine ligase activity
    		•  5.69075768451173 bayes_pls_golite062009
  • phosphopantothenoylcysteine decarboxylase activity
    		•  5.47152792211468 bayes_pls_golite062009
  • ligase activity
    		•  2.22669253992824 bayes_pls_golite062009
  • binding
    		•  1.89072001556053 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.60765845284251 bayes_pls_golite062009
  • catalytic activity
    		•  1.32370671504792 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.28899846789805 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.53776941010038 bayes_pls_golite062009
  • protein binding
    		•  0.395135807048731 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.133284065682966 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle