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Protein Overview: Prp18-PA

General Information:
Name(s) found: Prp18-PA / FBpp0083131 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Prp18 is referred to in FlyBase by the symbol Dmel\Prp18 (CG6011, FBgn0027784). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14855690..14856973. It has the cytological map location 91E4. It is reported to have molecular function</span>: poly(U) RNA binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: nuclear mRNA splicing, via spliceosome. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 340 amino acids

    Gene Ontology:
    Cellular Component: spliceosomal complex [ISS]
    Biological Process: nuclear mRNA splicing, via spliceosome [ISS][NAS]
    Molecular Function: poly(U) RNA binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDILKAEIAR KRKLLEQRQL VDEKKKYFRR GDLNAKNTEE VLQKVGYIKQ ESVEAQGQTT  60
   61 EGAYSFVADG QNILPRTEVI RRLRERGEPI LIFGETEPEA FDRLRQCEIS QPEANRGFRN 120
  121 DFQEAMEQVD AAYLQEMFAN TPTTKEDKKS DFAELDESVS WESIQTMAAN MGRNKDYDMD 180
  181 VIITLLTFLL KLWNDQIANY SKHEKMSTKV KMTRVIYTQT KEYVKPLFRK LKHHTLPEDI 240
  241 LDSLRDICKH LLNRNYITAS DAYLEMAIGN APWPIGVTMV GIHARTGREK IFSKNVAHVM 300
  301 NDETQRKYIQ GLKRLMTKCQ EYFPTDPSKC VEYVSKKDRE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..169] PSI-BLAST 3.045757 No description for 2i1jA was found.
    2 View Details [170..340] PSI-BLAST 45.39794 Functional domain of the splicing factor Prp18

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
    		• 8.4933513491836 bayes_pls_golite062009
  • second spliceosomal transesterification activity
    		•  5.51692977589724 bayes_pls_golite062009
  • catalytic activity
    		•  0.60409960326459 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle