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Protein Overview: gwl-PA

General Information:
Name(s) found: gwl-PA / FBpp0083089 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene greatwall is referred to in FlyBase by the symbol Dmel\gwl (CG7719, FBgn0260399). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14572094..14576082. It has the cytological map location 91C5-91C6. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of meiosis; female meiosis I; regulation of mitotic centrosome separation; regulation of mitotic cell cycle; mitosis; regulation of mitosis; chromosome condensation. 22 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; peripheral nervous system; intracellular organelle part; intracellular non-membrane-bounded organelle; embryonic nervous system; cytoplasmic part; female germline cyst; spindle; egg; cell cycle; external compound sense organ; chromatin; commissure; adult segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 846 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of mitosis [IMP]
    chromosome condensation [IMP]
    regulation of meiosis [IMP]
    mitosis [IMP]
    female meiosis I [IMP]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    regulation of mitotic cell cycle [IMP]
    regulation of mitotic centrosome separation [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENADATSQS DVHIDYKTPK KTHSLIDSEQ LLDKINILTT KPENHSQNAK LPTIKDFVII  60
   61 KPISRGAFGK VFLGYKNNDS KRLFAIKVMR KSEMINKNMV SQVITERNAL ALSRSQFCVS 120
  121 LFYSLQSLSY VYLVMEYMVG GDLKSLLAMF GYFDEPTARF YVAEMVMALQ YLHQHGIVHR 180
  181 DIKPDNMLLS SSGHVKLTDF GLSKIDMRRD LEISDLINCS PNLNARTPGQ LLSLTSHLSF 240
  241 GSEKKLNDFG SVSSGQNNGM GSVATGTSHL LQAINKHSLI MELSDSEGDT SLNDAEKTSD 300
  301 SKISGVSPFF SAEEANESIT HTCTTNVNPQ DSSSSCSFHT CNSADLSKCS PPLESKDGAA 360
  361 AGNAIPSKRR VEFVLDAAPC QGCKLAEQDS SNMATNDGKH LPKIDNAIEA SFEFSMVRRR 420
  421 SVDERNRISK GPEDSGVSSR KGDDYSSCHL NLNSESTASS IEKNVDNLSQ SKEDFSCSDY 480
  481 SRSYNVTNGN EMSGINMNSP FRNLSKHFKR PDFLRGMKRK INLVNRSDNM SSMDTDGCSS 540
  541 SNGSTNTGLT QEIEILNIGS STPKKRKARS SPIRGVLKVR SLSDDEMPIN HLLGPEANVA 600
  601 NVVFSTPVSS QKLPRRDGGL LGKLKATRFA LPLSIENKKR EHATADKMSG IQYHLKLSDD 660
  661 PTMSPINHGA GNLPKTPKNV NINTPFRTPK SVRRGARVSN ERILGTPDYL APELLLKQGH 720
  721 GPAVDWWALG VCFYEFMTGI PPFNDETPQK VFDNILNKNI EWPEGDEALS VESMEAVELL 780
  781 LTMDPNERPA AKEVQQMRHF ACIDWENIGN TEPPFVPTPD NPTDTGYFDA RNNLQHLQLS 840
  841 NFALEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..368] PSI-BLAST 76.30103 cAMP-dependent PK, catalytic subunit
    2 View Details [369..535] deduced N/A No confident structure predictions are available.
    3 View Details [536..846] PSI-BLAST 51.522879 No description for 2a2aA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  0.686492203566958 bayes_pls_golite062009
  • transferase activity
    		•  0.66841261245817 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.66326000691279 bayes_pls_golite062009
  • kinase activity
    		•  0.65753777854807 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.64444215862273 bayes_pls_golite062009
  • protein kinase activity
    		•  0.56587465829201 bayes_pls_golite062009
  • binding
    		•  0.0554152720226 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle