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View Structure Prediction Details

Protein: gwl-PA
Organism: Drosophila melanogaster
Length: 846 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gwl-PA.

Description E-value Query
Range
Subject
Range
gi|54638728, gi|... - gi|54638728|gb|EAL28130.1| GA20542 [Drosophila pseudoobscura pseudoobscura], gi|125775570|ref|XP_001...
gi|54638728|gb|E... - GA20542-PA [Drosophila pseudoobscura], GA20542 [Drosophila pseudoobscura pseudoobscura]
398.0 [0..1] [846..1]

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Predicted Domain #1
Region A:
Residues: [1-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENADATSQS DVHIDYKTPK KTHSLIDSEQ LLDKINILTT KPENHSQNAK LPTIKDFVII  60
   61 KPISRGAFGK VFLGYKNNDS KRLFAIKVMR KSEMINKNMV SQVITERNAL ALSRSQFCVS 120
  121 LFYSLQSLSY VYLVMEYMVG GDLKSLLAMF GYFDEPTARF YVAEMVMALQ YLHQHGIVHR 180
  181 DIKPDNMLLS SSGHVKLTDF GLSKIDMRRD LEISDLINCS PNLNARTPGQ LLSLTSHLSF 240
  241 GSEKKLNDFG SVSSGQNNGM GSVATGTSHL LQAINKHSLI MELSDSEGDT SLNDAEKTSD 300
  301 SKISGVSPFF SAEEANESIT HTCTTNVNPQ DSSSSCSFHT CNSADLSKCS PPLESKDGAA 360
  361 AGNAIPSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.30103
Match: 1ctpE
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.686492203566958 bayes_pls_golite062009
transferase activity 0.66841261245817 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.66326000691279 bayes_pls_golite062009
kinase activity 0.65753777854807 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.64444215862273 bayes_pls_golite062009
protein kinase activity 0.56587465829201 bayes_pls_golite062009
binding 0.0554152720226 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [369-535]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRVEFVLDAA PCQGCKLAEQ DSSNMATNDG KHLPKIDNAI EASFEFSMVR RRSVDERNRI  60
   61 SKGPEDSGVS SRKGDDYSSC HLNLNSESTA SSIEKNVDNL SQSKEDFSCS DYSRSYNVTN 120
  121 GNEMSGINMN SPFRNLSKHF KRPDFLRGMK RKINLVNRSD NMSSMDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [536-846]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGCSSSNGST NTGLTQEIEI LNIGSSTPKK RKARSSPIRG VLKVRSLSDD EMPINHLLGP  60
   61 EANVANVVFS TPVSSQKLPR RDGGLLGKLK ATRFALPLSI ENKKREHATA DKMSGIQYHL 120
  121 KLSDDPTMSP INHGAGNLPK TPKNVNINTP FRTPKSVRRG ARVSNERILG TPDYLAPELL 180
  181 LKQGHGPAVD WWALGVCFYE FMTGIPPFND ETPQKVFDNI LNKNIEWPEG DEALSVESME 240
  241 AVELLLTMDP NERPAAKEVQ QMRHFACIDW ENIGNTEPPF VPTPDNPTDT GYFDARNNLQ 300
  301 HLQLSNFALE E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.522879
Match: 2a2aA
Description: No description for 2a2aA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle