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Protein Overview: fru-PE

General Information:
Name(s) found: fru-PE / FBpp0083063 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene fruitless is referred to in FlyBase by the symbol Dmel\fru (CG14307, FBgn0004652). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14242315..14371308. It has the cytological map location 91A7-91B3. It is reported to have molecular function</span>: RNA polymerase II transcription factor activity; transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: male courtship behavior, veined wing generated song production; central nervous system development; aggressive behavior; mating; multicellular organismal development; muscle organ development; mating behavior; male courtship behavior, veined wing vibration; male courtship behavior; sex determination. 92 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: adult segment; embryonic nervous system; embryonic neuron; antennal segment; multi-cell-component structure; nervous system; adult mesothoracic segment; organ system; embryonic glial cell; serotonergic neuron. It has 14 annotated transcripts and 14 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 955 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    intracellular [IEA]
    Biological Process: multicellular organismal development [IMP]
    male courtship behavior [IMP][NAS][TAS]
    copulation [NAS][TAS]
    male courtship behavior, veined wing generated song production [IMP][TAS]
    sex determination [IMP][TAS]
    muscle organ development [IMP]
    mating behavior [IMP]
    central nervous system development [IMP][TAS]
    aggressive behavior [IMP]
    mating [IMP]
    mating behavior, sex discrimination [TAS]
    male sex differentiation [TAS]
    male courtship behavior, orientation prior to leg tapping and wing vibration [NAS]
    male courtship behavior, veined wing vibration [IMP]
    Molecular Function: transcription factor activity [NAS][TAS]
    zinc ion binding [IEA]
    protein binding [IEA]
    RNA polymerase II transcription factor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMATSQDYFG NPYALFRGPP TTLRPRESPL GVGHPHGHGH LHSHAHAHGH GHAHSHYAAL  60
   61 DLQTPHKRNI ETDVRAPPPP LPPPPLPLPP ASPRYNTDQG AMDQQFCLRW NNHPTNLTGV 120
  121 LTSLLQREAL CDVTLACEGE TVKAHQTILS ACSPYFETIF LQNQHPHPII YLKDVRYSEM 180
  181 RSLLDFMYKG EVNVGQSSLP MFLKTAESLQ VRGLTDNNNL NYRSDCDKLR DSAASSPTGR 240
  241 GPSNYTGGLG GAGGVADAMR ESRDSLRSRC ERDLRDELTQ RSSSSMSERS SAAAAAAAAA 300
  301 AAVAAAGGNV NAAAVALGLT TPTGGERSPS VGSASAAAAA AAVAAAVAAA ANRSASADGC 360
  361 SDRGSERGTL ERTDSRDDLL QLDYSNKDNN NSNSSSTGGN NNNNNNNNNN SSSNNNNSSS 420
  421 NRERNNSGER ERERERERER DRDRELSTTP VEQLSSSKRR RKNSSSNCDN SLSSSHQDRH 480
  481 YPQDSQANFK SSPVPKTGGS TSESEDAGGR HDSPLSMTTS VHLGGGGGNV GAASALSGLS 540
  541 QSLSIKQELM DAQQQQQHRE HHVALPPDYL PSAALKLHAE DMSTLLTQHA LQAADARDEH 600
  601 NDAKQLQLDQ TDNIDGRVKC FNIKHDRHPD RELDRNHREH DDDPGVIEEV VVDHVREMEA 660
  661 GNEHDPEEMK EAAYHATPPK YRRAVVYAPP HPDEEAASGS GSDIYVDGGY NCEYKCKELN 720
  721 MRAIRCSRQQ HMMSHYSPHH PHHRSLIDCP AEAAYSPPVA NNQAYLASNG AVQQLDLSTY 780
  781 HGHANHQLHQ HPPSATHPSH SQSSPHYPSA SGAGAGAGSV SVSIAGSASG SATSAPASVA 840
  841 TSAVSPQPSS SSTGSTSSAA AVAAAAAAAA NRRDHNIDYS TLFVQLSGTL PTLYRCVSCN 900
  901 KIVSNRWHHA NIHRPQSHEC PVCGQKFTRR DNMKAHCKIK HADIKDRFFS HYVHM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] deduced N/A No confident structure predictions are available.
    2 View Details [100..217] PSI-BLAST 37.0 No description for 2nn2A was found.
    3 View Details [218..289] deduced N/A No confident structure predictions are available.
    4 View Details [290..363] deduced N/A No confident structure predictions are available.
    5 View Details [364..473] deduced N/A No confident structure predictions are available.
    6 View Details [474..654] MSA 5.670994 View MSA. No confident structure predictions are available.
    7 View Details [655..795] PSI-BLAST 7.69897 Five-finger GLI1
    8 View Details [796..955] PSI-BLAST 32.69897 No description for 2i13A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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