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Protein Overview: 14-3-3epsilon-PA

General Information:
Name(s) found: 14-3-3epsilon-PA / FBpp0082987 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene 14-3-3Ã?&#142;Ã?µ is referred to in FlyBase by the symbol Dmel\14-3-3Ã?&#142;Ã?µ (CG31196, FBgn0020238). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14068253..14074388. It has the cytological map location 90F10. There is experimental evidence that it has the molecular function</span>: SUMO binding. There is experimental evidence that it is involved in the biological process</span>: response to external stimulus; germarium-derived oocyte fate determination; oocyte microtubule cytoskeleton polarization; regulation of mitosis; wing disc dorsal/ventral pattern formation; DNA damage checkpoint. 27 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; eye; oocyte; anterior crossvein; eye photoreceptor cell; ommatidium; cycle 14 embryo. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 262 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    germline ring canal [IDA]
    cytoplasm [IDA]
    chromosome [IDA]
    Biological Process: DNA damage checkpoint [IMP][TAS]
    nonassociative learning [NAS]
    mitotic cell cycle checkpoint [TAS]
    response to external stimulus [IMP]
    regulation of mitosis [IMP]
    germarium-derived oocyte fate determination [IMP]
    response to radiation [TAS]
    imaginal disc development [TAS]
    oocyte microtubule cytoskeleton polarization [IMP]
    wing disc dorsal/ventral pattern formation [IGI]
    Ras protein signal transduction [NAS]
    Molecular Function: SUMO binding [IPI]
    protein domain specific binding [IEA]
    protein kinase C inhibitor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTERENNVYK AKLAEQAERY DEMVEAMKKV ASMDVELTVE ERNLLSVAYK NVIGARRASW  60
   61 RIITSIEQKE ENKGAEEKLE MIKTYRGQVE KELRDICSDI LNVLEKHLIP CATSGESKVF 120
  121 YYKMKGDYHR YLAEFATGSD RKDAAENSLI AYKAASDIAM NDLPPTHPIR LGLALNFSVF 180
  181 YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQAEEV 240
  241 DPNAGDGEPK EQIQDVEDQD VS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..262] PSI-BLAST 97.69897 14-3-3 Protein Epsilon (Human) Complexed to Peptide


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle