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Protein Overview: Prx5-PB, Prx5-PA

General Information:
Name(s) found: Prx5-PB / FBpp0100080 [FlyBase]
Prx5-PA / FBpp0100079 [FlyBase]
Description(s) found:
Found 41 descriptions.
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  • The gene Peroxiredoxin 5 is referred to in FlyBase by the symbol Dmel\Prx5 (CG7217, FBgn0038570). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13991164..13992967. It has the cytological map location 90F4. Based on sequence similarity, it is predicted to have molecular function</span>: antioxidant activity. There is experimental evidence that it is involved in the biological process</span>: response to oxidative stress. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Peroxiredoxin 5 is referred to in FlyBase by the symbol Dmel\Prx5 (CG7217, FBgn0038570). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13991164..13992967. It has the cytological map location 90F4. Based on sequence similarity, it is predicted to have molecular function</span>: antioxidant activity. There is experimental evidence that it is involved in the biological process</span>: response to oxidative stress. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 190 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [ISS]
    nucleus [IDA]
    mitochondrion [IDA]
    cytosol [IDA]
    Biological Process: response to oxidative stress [IMP]
    cell redox homeostasis [IEA]
    Molecular Function: antioxidant activity [ISS]
    oxidoreductase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRVLSCKFLG RVVNSALPQQ IISLRSLSKT SAAMVKVGDS LPSVDLFEDS PANKINTGDL  60
   61 VNGKKVIIFG VPGAFTPGCS KTHLPGYVSS ADELKSKQGV DEIVCVSVND PFVMSAWGKE 120
  121 HGAAGKVRLL ADPAGGFTKA LDVTIDLPPL GGVRSKRYSL VVENGKVTEL NVEPDGTGLS 180
  181 CSLANNIGKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] PSI-BLAST 29.69897 HUMAN PEROXIREDOXIN 5

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • selenium binding
    		•  1.1082524159827 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.52671047749426 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.0801269279614203 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle