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Protein Overview: Dhfr-PB, Dhfr-PA

General Information:
Name(s) found: Dhfr-PB / FBpp0110210 [FlyBase]
Dhfr-PA / FBpp0082746 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene Dihydrofolate reductase is referred to in FlyBase by the symbol Dmel\Dhfr (CG14887, FBgn0004087). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12306921..12307601. It has the cytological map location 89B18. There is experimental evidence that it has the molecular function</span>: dihydrofolate reductase activity. It is reported to be involved in the biological process</span>: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; folic acid and derivative metabolic process; glycine biosynthetic process; 'de novo' IMP biosynthetic process; pyrimidine deoxyribonucleotide interconversion. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Dihydrofolate reductase is referred to in FlyBase by the symbol Dmel\Dhfr (CG14887, FBgn0004087). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12306921..12307601. It has the cytological map location 89B18. There is experimental evidence that it has the molecular function</span>: dihydrofolate reductase activity. It is reported to be involved in the biological process</span>: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; folic acid and derivative metabolic process; glycine biosynthetic process; 'de novo' IMP biosynthetic process; pyrimidine deoxyribonucleotide interconversion. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 182 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nucleotide biosynthetic process [IEA]
    'de novo' IMP biosynthetic process [NAS]
    oxidation reduction [IEA]
    folic acid and derivative metabolic process [NAS]
    pyrimidine deoxyribonucleotide interconversion [NAS]
    glycine biosynthetic process [IEA][NAS]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [NAS]
    Molecular Function: NADP or NADPH binding [IEA]
    dihydrofolate reductase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRFNLIVAV CENFGIGIRG DLPWRIKSEL KYFSRTTKRT SDPTKQNAVV MGRKTYFGVP  60
   61 ESKRPLPDRL NIVLSTTLQE SDLPKGVLLC PNLETAMKIL EEQNEVENIW IVGGSGVYEE 120
  121 AMASPRCHRL YITKIMQKFD CDTFFPAIPD SFREVAPDSD MPLGVQEENG IKFEYKILEK 180
  181 HS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..182] PSI-BLAST 51.045757 No description for 2fzjA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle