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Protein Overview: FBpp0306660, alp...

General Information:
Name(s) found: FBpp0311424 [FlyBase]
FBpp0306660 [FlyBase]
alpha-Man-IIb-PA / FBpp0082633 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=3R:join(11644733..11645146,11645206..11647225,11647285..11647828,11647888..11648659); ID=FBpp0311424; name=alpha-Man-IIb-PC; parent=FBgn0026616,FBtr0345238; dbxref=FlyBase:FBpp0311424,FlyBase_Annotation_IDs:CG4606-PC; MD5=11f154f95098f495a44a10dff14980d2; length=1249; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=3R:join(11644733..11645146,11645206..11647225,11647285..11647828,11647888..11648659); ID=FBpp0306660; name=alpha-Man-IIb-PB; parent=FBgn0026616,FBtr0334593; dbxref=FlyBase:FBpp0306660,FlyBase_Annotation_IDs:CG4606-PB,REFSEQ:NP_001262614,GB_protein:AGB95994; MD5=11f154f95098f495a44a10dff14980d2; length=1249; release=r5.56; species=Dmel; [FlyBase]
  • The gene Ã?&#142;Ã?±-Man-IIb is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-IIb (CG4606, FBgn0026616). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11629974..11649840. It has the cytological map location 89A5. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; alpha-mannosidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: mannose metabolic process. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1249 amino acids

    Gene Ontology:
    Cellular Component: Golgi membrane [ISS]
    Biological Process: mannose metabolic process [IEA]
    Molecular Function: alpha-mannosidase activity [ISS][NAS]
    zinc ion binding [IEA]
    mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [ISS]
    carbohydrate binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFKLFRRGS ARCIGLLSAF VTILLCLYYI SIGQPNPTPI SETGAPSAAL RGSPLSGLTG  60
   61 FSVDGGSSSI IHQQKQQLVI ASNQKKSSET KSAQTSVSPE EQSEEQYTNS NWGDKCYELI 120
  121 QSNTNITASE EHSKFDFQPE WMRSKEYWDR GFEERFDAQK KDKQRPPLKI IVVPHSHNDP 180
  181 GWLKTFTNYF QSDSRQILNL LVTKMQEYTD MTFIWSEISF LQLWWDQAHP TKQRALKRLI 240
  241 DAGRIEITTG GWVMTDEANV HIYPMLDQLI EGHQWLKNNL NVTPKVGWSI DPFGHGSTVP 300
  301 YLLSGANFEG TIIQRIHYAW KQWFARQQSG DFIWKPYWRS RKDKDSEAGS LLTHNMPFDI 360
  361 YSIKGSCGPH PFICLNFDFR KIPGEYTEYS VKAQFITDDN LESKAQLLLE QYARTASLFP 420
  421 HNVALIPVGD DFRYNKDREV DQQYQNYKKL IDHIMANRRL YNADIRFGTP SDYFEAIKER 480
  481 MKDHTPGFPT FKGDFFVYSD IFSEGRPAYW SGYFTTRPFY KLLSSELEHQ LRSAEIVFTL 540
  541 AYNTARQAKR ENAIKIYEKN YELIINARRN LGLFQHHDAI TGTSKAAVMR DYAMRLFEST 600
  601 QNMVKMQESC LELLLQKGQP RHHGFLLSEF ERDNFNKLPR KMPIQMANGD ESTPTVPAGE 660
  661 GGAGGSSSSG SVGSFVLYNS LAQKRLEVVT LRVQHPNVKI VNDKGVELNH IQINPVWNIT 720
  721 DTYEQGLGTS VSGTVGRIRT STRQFEVMFV AELEPLSLST YRVQVDEVNF KRNIATIYCD 780
  781 DCTESQPASV SPPEEIESSP TSVFEARGKP AGDIQLENPH MRLLFDEKSG FLKTITRKNQ 840
  841 KKELLKPLQC NIKFAAYRSA QFHSGAYLFK TDPEQSEAEK EVLEGYTDMR IIITSGPIAS 900
  901 DVTVIYGPFL AHTVRIFNTR THLDAAIYVE NDIDFEPPPK NRETELFMRF VTNIDNIAQA 960
  961 PMQRDPLKEP VDAATMPELP VFYSDQNGFQ YHERIKVPAI GIEGNYFPIT SGAFIQDSRL1020
 1021 RLTLLTTHAQ GAASYEPGQL EVMLDRRTLY DDYRGMGEGV VDSRLTRHKF WLLVEDLPGG1080
 1081 QHVTQPPSYK VLSQQAQQLA NALRYPPNLY FVSNLEQPEL AAALLPLVRL LPKGPLPCDV1140
 1141 HLTTLRTLSD PELQLFPSAS ALLVLHRQGF DCSVSAGREL SMEAICPLSS KGLGNVQLGR1200
 1201 LSLHTIEATS LTGTEQKSSR ESYHIRSLAE ISLEPMELRT FNLTFRSEV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] deduced N/A No confident structure predictions are available.
    2 View Details [100..1249] PSI-BLAST 1000.0 Golgi alpha-mannosidase II in complex with kifunensine

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mannosidase activity
    		•  6.01915916767417 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  4.31715812247646 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.59000499388951 bayes_pls_golite062009
  • hydrolase activity
    		•  3.47408297144232 bayes_pls_golite062009
  • alpha-mannosidase activity
    		•  3.43578718881717 bayes_pls_golite062009
  • mannosyl-oligosaccharide mannosidase activity
    		•  2.67474348614438 bayes_pls_golite062009
  • deacetylase activity
    		•  2.13686837707321 bayes_pls_golite062009
  • binding
    		•  1.29644842078336 bayes_pls_golite062009
  • catalytic activity
    		•  1.17882014774774 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  1.00994109266252 bayes_pls_golite062009
  • racemase and epimerase activity, acting on carbohydrates and derivatives
    		•  0.68102716507433 bayes_pls_golite062009
  • aldose 1-epimerase activity
    		•  0.521235680233587 bayes_pls_golite062009
  • mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
    		•  0.511393435253234 bayes_pls_golite062009
  • racemase and epimerase activity
    		•  0.473636146090495 bayes_pls_golite062009
  • protein binding
    		•  0.394432087623352 bayes_pls_golite062009
  • isomerase activity
    		•  0.106573908779409 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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