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Protein Overview: CG12241-PA

General Information:
Name(s) found: CG12241-PA / FBpp0082510 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG12241 (CG12241, FBgn0038304). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11044984..11048093. It has the cytological map location 88E3. Based on sequence similarity, it is predicted to have molecular function</span>: GTPase activator activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: regulation of Rab GTPase activity. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 804 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: regulation of Rab GTPase activity [IEA]
    Molecular Function: Rab GTPase activator activity [IEA]
    GTPase activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMARSIFGR DHEGYVGREE HTRKLQNLGS EDDLGELPPM MEELSVADGL RPNPGGPFSA  60
   61 LTASMWPQEI LAKLGGGAEL ASGPNDQPEY RFDEFGFRVE EEDGPEQSSN KLLSIPFVED 120
  121 AQQRLQWIAH LEFSHNKEAA ELSWEHVDVM LPRTEKLRNM VRQGIPHTLR AQMWMRLSGA 180
  181 LAKKQKSETS YHDIVKASSN DQLMTSKQIE KDLLRILPTN ACFSNPNGTG IPRLRRILRG 240
  241 IAWLFPDIGY CQGTGVIVAC LLLFMEEENA FWMMATIVED LLPASYYSST LLGIQADQRV 300
  301 MHTLIANYLS SVDESLRKHD IELSLITLHW FLTLFANVVH MKILVRIWDW FFYEGSIVLF 360
  361 QLTLGMLKVK EQDLKHLENS AQIFNSLSDI PGEVTDVEVL FRQALEVGGS LSQTVIDTHR 420
  421 RRHLAYLMAD QGHQIGNPEA APNLPKQQLA RRQVRKSKSI LEAFLFRGDG NEGDQLKNKN 480
  481 IRQTEILVDL REAILKVGRH FITIEPKLAG HIQLTANYST ESHAKDHENF INVARTRKRR 540
  541 AKALHDFERH DDDELGFRRN DIITIISQKD EHCWVGELNG LRGWFPAKFV ELLDERSKLY 600
  601 TSAGDDAISE TVTDLVRGTL APAIKAFLEH GMKRPTFLGG PIHPWLYIEE AATREVEKDF 660
  661 ESVYSRLVLC KTYRLDEDGK VLTPEELLYR CVQAINQTHD DAHAQMDVKL RSLICLGLNE 720
  721 QVLHLWLEVL CACQEVVQKW YHSWSFIDSP GWVQIKCELR ILSQFAFNLN PDWELPPKRG 780
  781 KESQPLKDGV RDMLVKHHLF SWDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] deduced N/A No confident structure predictions are available.
    2 View Details [133..410] PSI-BLAST 41.69897 No description for 2qq8A was found.
    3 View Details [411..516] deduced N/A No confident structure predictions are available.
    4 View Details [517..601] PSI-BLAST 10.522879 No description for 2yuoA was found.
    5 View Details [602..804] FFAS03 4.49 Crystal structure of the RUN domain of mouse Rap2 interacting protein x

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  1.27452151981956 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.494334646727489 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.486497145594666 bayes_pls_golite062009
  • protein binding
    		•  0.475249677998289 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.42885736301714 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.203717853422064 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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