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View Structure Prediction Details

Protein: CG12241-PA
Organism: Drosophila melanogaster
Length: 804 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG12241-PA.

Description E-value Query
Range
Subject
Range
gi|195157156, gi... - gi|195157156|ref|XP_002019462.1| GL12411 [Drosophila persimilis], gi|194116053|gb|EDW38096.1| GL1241...
gi|198477561, gi... - gi|198477561|ref|XP_002136552.1| GA27657 [Drosophila pseudoobscura pseudoobscura], gi|198142840|gb|E...
gi|54639474, gi|... - gi|54639474|gb|EAL28876.1| GA11502 [Drosophila pseudoobscura pseudoobscura], gi|125777776|ref|XP_001...
596.0 [0..1] [804..1]

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Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMARSIFGR DHEGYVGREE HTRKLQNLGS EDDLGELPPM MEELSVADGL RPNPGGPFSA  60
   61 LTASMWPQEI LAKLGGGAEL ASGPNDQPEY RFDEFGFRVE EEDGPEQSSN KLLSIPFVED 120
  121 AQQRLQWIAH LE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [133-410]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSHNKEAAEL SWEHVDVMLP RTEKLRNMVR QGIPHTLRAQ MWMRLSGALA KKQKSETSYH  60
   61 DIVKASSNDQ LMTSKQIEKD LLRILPTNAC FSNPNGTGIP RLRRILRGIA WLFPDIGYCQ 120
  121 GTGVIVACLL LFMEEENAFW MMATIVEDLL PASYYSSTLL GIQADQRVMH TLIANYLSSV 180
  181 DESLRKHDIE LSLITLHWFL TLFANVVHMK ILVRIWDWFF YEGSIVLFQL TLGMLKVKEQ 240
  241 DLKHLENSAQ IFNSLSDIPG EVTDVEVLFR QALEVGGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 2qq8A
Description: No description for 2qq8A was found.

Predicted Domain #3
Region A:
Residues: [411-516]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSQTVIDTHR RRHLAYLMAD QGHQIGNPEA APNLPKQQLA RRQVRKSKSI LEAFLFRGDG  60
   61 NEGDQLKNKN IRQTEILVDL REAILKVGRH FITIEPKLAG HIQLTA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [517-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYSTESHAKD HENFINVART RKRRAKALHD FERHDDDELG FRRNDIITII SQKDEHCWVG  60
   61 ELNGLRGWFP AKFVELLDER SKLYT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 2yuoA
Description: No description for 2yuoA was found.

Predicted Domain #5
Region A:
Residues: [602-804]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAGDDAISET VTDLVRGTLA PAIKAFLEHG MKRPTFLGGP IHPWLYIEEA ATREVEKDFE  60
   61 SVYSRLVLCK TYRLDEDGKV LTPEELLYRC VQAINQTHDD AHAQMDVKLR SLICLGLNEQ 120
  121 VLHLWLEVLC ACQEVVQKWY HSWSFIDSPG WVQIKCELRI LSQFAFNLNP DWELPPKRGK 180
  181 ESQPLKDGVR DMLVKHHLFS WDL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.49
Match: 2cxfA
Description: Crystal structure of the RUN domain of mouse Rap2 interacting protein x
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.27452151981956 bayes_pls_golite062009
GTPase regulator activity 0.494334646727489 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.486497145594666 bayes_pls_golite062009
protein binding 0.475249677998289 bayes_pls_golite062009
small GTPase regulator activity 0.42885736301714 bayes_pls_golite062009
enzyme regulator activity 0.203717853422064 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle