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Protein Overview: Orc2-PA

General Information:
Name(s) found: Orc2-PA / FBpp0082329 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Origin recognition complex subunit 2 is referred to in FlyBase by the symbol Dmel\Orc2 (CG3041, FBgn0015270). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:9790639..9792803. It has the cytological map location 88A3. It is reported to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: mitotic chromosome condensation; DNA replication initiation; cell proliferation; eggshell chorion gene amplification; mitotic spindle organization; DNA replication; chromosome condensation. 26 alleles are reported. The phenotypes of these alleles are annotated with: chromosome, centromeric region; chorion; mitotic cell cycle; follicle cell; spindle; nuclear chromosome; cell cycle; imaginal disc; mitotic metaphase. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 618 amino acids

    Gene Ontology:
    Cellular Component: nuclear origin of replication recognition complex [IDA][ISS][NAS]
    Biological Process: cell proliferation [IMP]
    DNA replication initiation [IDA]
    eggshell chorion gene amplification [IMP][TAS]
    mitotic chromosome condensation [IMP]
    DNA replication [IEA][IMP][ISS][TAS]
    mitotic spindle organization [IMP]
    DNA-dependent DNA replication [ISS][NAS]
    chromosome condensation [IMP]
    chromatin silencing [NAS]
    Molecular Function: DNA binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSASNKGGYK TPRKENLMSI ENLTNSEEES EDLNTAMVGN AVESQPKVTS RRSTRRPSPT  60
   61 KKYQAYQKES NGKGQEERIV VNYVEMSDER SSDAEDQEEE ESIEESENAA RPAAKDLHLI 120
  121 QSEYNVAGTS MFGFNTPKKR DAMALAALNA TPCTPKTPKT PRLGVKTPDT KRKKSMDQPK 180
  181 TPAHVRTRVK KQIAKIVADS DEDFSGDESD FRPSDEESSS SSSSSDAGNS SDNDAADDEP 240
  241 KTPSRARRAI VVPVLPKTPS AARLRQSARA KKSNEFVPES DGYFHSHASS KILTSDHTLD 300
  301 RLKNPRLAAD RVFSLLSEIK TSAEHEGSIN AIMEEYRSYF PKWMCILNEG FNILLYGLGS 360
  361 KHQLLQSFHR EVLHKQTVLV VNGFFPSLTI KDMLDSITSD ILDAGISPAN PHEAVDMIEE 420
  421 EFALIPETHL FLIVHNLDGA MLRNVKAQAI LSRLARIPNI HLLASIDHIN TPLLWDQGKL 480
  481 CSFNFSWWDC TTMLPYTNET AFENSLLVQN SGELALSSMR SVFSSLTTNS RGIYMLIVKY 540
  541 QLKNKGNATY QGMPFRDLYS SCREAFLVSS DLALRAQLTE FLDHKLVKSK RSVDGSEQLT 600
  601 IPIDGALLQQ FLEEQEKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..245] MSA 7.225996 View MSA. No confident structure predictions are available.
    2 View Details [246..316] deduced N/A No confident structure predictions are available.
    3 View Details [317..618] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle