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Protein Overview: primo-1-PB, prim...

General Information:
Name(s) found: primo-1-PB / FBpp0099895 [FlyBase]
primo-1-PA / FBpp0099893 [FlyBase]
Description(s) found:
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  • gi|78706768|ref|NP_001027187.1| primo-1, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|78706766|ref|NP_001027186.1| primo-1, isoform B [Drosophila melanogaster] [NCBI NR]
  • ref|NP_788672.1| CG31311-PD [Drosophila melanogaster] [NCBI NR]
  • ref|NP_731856.2| CG31311-PB [Drosophila melanogaster] [NCBI NR]
  • gi|28381291|gb|AAO41564.1| primo-1, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|28381290|gb|AAN13591.2| primo-1, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|14285673|sp|P82890.1|PPAC1_DROME RecName: Full=Low molecular weight phosphotyrosine protein phosphatase 1; AltName: Full=Low molecular weight cytosolic acid phosphatase 1; AltName: Full=PTPase 1 [NCBI NR]
  • Low molecular weight phosphotyrosine protein phosphatase 1 OS=Drosophila melanogaster GN=primo-1 PE=2 SV=1 [Swiss-Prot]
  • Low molecular weight phosphotyrosine protein phosphatase 1 - Drosophila melanogaster (Fruit fly) [Swiss-Prot]
  • The gene primo-1 is referred to in FlyBase by the symbol Dmel\primo-1 (CG33748, FBgn0040077). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:9535748..9537557. It has the cytological map location 87F12. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine phosphatase activity; acid phosphatase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid dephosphorylation. 2 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG31311-PB translation from_gene[CG31311 CG31311 FBgn0051311] seq_release:3 mol_weight=17557 cds_boundaries:(3R:9,535,811..9,536,494[-]) aa_length:155 transcript_info:[CG31311-RB seq_release:3] gene_info:[gene symbol:CG31311 FBgn0051311 gene_boundarie [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG31311-PD translation from_gene[CG31311 CG31311 FBgn0051311] seq_release:3 mol_weight=17557 cds_boundaries:(3R:9,535,811..9,536,494[-]) aa_length:155 transcript_info:[CG31311-RD seq_release:3] gene_info:[gene symbol:CG31311 FBgn0051311 gene_boundarie [hmr_yeast5_DM3-1_pombe.fasta]
  • (P82890) Low molecular weight phosphotyrosine protein phosphatase 1 (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase 1) (EC 3.1.3.2) (PTPase 1) [DrosMelano7227.FASTAC.txt]
  • CG31311-PD, isoform D [Drosophila melanogaster]gi|28381290|gb|AAN13591.2| CG31311-PB, isoform B [Drosophila melanogaster]gi|28573017|ref|NP_788672.1| CG31311-PD [Drosophila melanogaster]gi|28573012|ref|NP_731856.2| CG31311-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(9535789..9535875,9536031..9536380,9536445..9536475); ID=FBpp0099893; name=primo-1-PA; parent=FBgn0040077,FBtr0091747; dbxref=FlyBase_Annotation_IDs:CG33748-PA,FlyBase:FBpp0099893,GB_protein:AAN13591.2,REFSEQ:NP_001027187,GB [fly-100309-contam.fasta]
  • type=protein; loc=3R:complement(9535789..9535875,9536031..9536380,9536445..9536475); ID=FBpp0099895; name=primo-1-PB; parent=FBgn0040077,FBtr0091748; dbxref=FlyBase_Annotation_IDs:CG33748-PB,FlyBase:FBpp0099895,GB_protein:AAO41564.1,REFSEQ:NP_001027186,GB [fly-100309-contam.fasta]
  • CG33748-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG33748-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Low molecular weight phosphotyrosine protein phosphatase 1 (Low molecular weight cytosolic acid phosphatase 1) (PTPase 1) [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(9535789..9535875,9536031..9536380,9536445..9536475); ID=FBpp0099893; name=primo-1-PA; parent=FBgn0040077,FBtr0091747; dbxref=FlyBase_Annotation_IDs:CG33748-PA,FlyBase:FBpp0099893,GB_protein:AAN13591.2,REFSEQ:NP_001027187,GB_protein:AAN13591; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(9535789..9535875,9536031..9536380,9536445..9536475); ID=FBpp0099895; name=primo-1-PB; parent=FBgn0040077,FBtr0091748; dbxref=FlyBase_Annotation_IDs:CG33748-PB,FlyBase:FBpp0099895,GB_protein:AAO41564.1,REFSEQ:NP_001027186,GB_protein:AAO41564; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(9535789..9535875,9536031..9536380,9536445..9536475); ID=FBpp0099893; name=primo-1-PA; parent=FBgn0040077,FBtr0091747; dbxref=FlyBase_Annotation_IDs:CG33748-PA,FlyBase:FBpp0099893,GB_protein:AAN13591.2,REFSEQ:NP_001027187,GB_protein:AAN13591; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:complement(9535789..9535875,9536031..9536380,9536445..9536475); ID=FBpp0099895; name=primo-1-PB; parent=FBgn0040077,FBtr0091748; dbxref=FlyBase_Annotation_IDs:CG33748-PB,FlyBase:FBpp0099895,GB_protein:AAO41564.1,REFSEQ:NP_001027186,GB_protein:AAO41564; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • TA01420p OS=Drosophila melanogaster GN=primo-1-RB PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(9535789..9535875,9536031..9536380,9536445..9536475); ID=FBpp0099893; name=primo-1-PA; parent=FBgn0040077,FBtr0091747; dbxref=FlyBase_Annotation_IDs:CG33748-PA,FlyBase:FBpp0099893,GB_protein:AAN13591.2,REFSEQ:NP_001027187,GB_protein:AAN13591; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(9535789..9535875,9536031..9536380,9536445..9536475); ID=FBpp0099895; name=primo-1-PB; parent=FBgn0040077,FBtr0091748; dbxref=FlyBase_Annotation_IDs:CG33748-PB,FlyBase:FBpp0099895,GB_protein:AAO41564.1,REFSEQ:NP_001027186,GB_protein:AAO41564,FlyMine:FBpp0099895,modMine:FBpp0099895; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(13710723..13710753,13710309..13710658,13710067..13710153)); ID=FBpp0099893; name=primo-1-PA; parent=FBgn0040077,FBtr0091747; dbxref=FlyBase_Annotation_IDs:CG33748-PA,FlyBase:FBpp0099893,GB_protein:AAN13591.2,REFSEQ:NP_001027187,GB_protein:AAN13591; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(13710723..13710753,13710309..13710658,13710067..13710153)); ID=FBpp0099895; name=primo-1-PB; parent=FBgn0040077,FBtr0091748; dbxref=FlyBase_Annotation_IDs:CG33748-PB,FlyBase:FBpp0099895,GB_protein:AAO41564.1,REFSEQ:NP_001027186,GB_protein:AAO41564,FlyMine:FBpp0099895,modMine:FBpp0099895; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(13710723..13710753,13710309..13710658,13710067..13710153)); ID=FBpp0099893; name=primo-1-PA; parent=FBgn0040077,FBtr0091747; dbxref=FlyBase_Annotation_IDs:CG33748-PA,FlyBase:FBpp0099893,GB_protein:AAN13591.2,REFSEQ:NP_001027187,GB_protein:AAN13591; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3R:complement(join(13710723..13710753,13710309..13710658,13710067..13710153)); ID=FBpp0099895; name=primo-1-PB; parent=FBgn0040077,FBtr0091748; dbxref=FlyBase_Annotation_IDs:CG33748-PB,FlyBase:FBpp0099895,GB_protein:AAO41564.1,REFSEQ:NP_001027186,GB_protein:AAO41564,FlyMine:FBpp0099895,modMine:FBpp0099895; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0099893 type=protein; loc=3R:complement(join(13710723..13710753,13710309..13710658,13710067..13710153)); ID=FBpp0099893; name=primo-1-PA; parent=FBgn0040077,FBtr0091747; dbxref=FlyBase_Annotation_IDs:CG33748-PA,FlyBase:FBpp0099893,GB_protein:AAN13591.2,REFSEQ:NP_001027187,GB_protein:AAN13591; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0099895 type=protein; loc=3R:complement(join(13710723..13710753,13710309..13710658,13710067..13710153)); ID=FBpp0099895; name=primo-1-PB; parent=FBgn0040077,FBtr0091748; dbxref=FlyBase_Annotation_IDs:CG33748-PB,FlyBase:FBpp0099895,GB_protein:AAO41564.1,REFSEQ:NP_001027186,GB_protein:AAO41564,FlyMine:FBpp0099895,modMine:FBpp0099895; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(13710723..13710753,13710309..13710658,13710067..13710153)); ID=FBpp0099893; name=primo-1-PA; parent=FBgn0040077,FBtr0091747; dbxref=FlyBase_Annotation_IDs:CG33748-PA,FlyBase:FBpp0099893,GB_protein:AAN13591.2,REFSEQ:NP_001027187,GB_protein:AAN13591,UniProt/Swiss-Prot:P82890; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3R:complement(join(13710723..13710753,13710309..13710658,13710067..13710153)); ID=FBpp0099895; name=primo-1-PB; parent=FBgn0040077,FBtr0091748; dbxref=FlyBase_Annotation_IDs:CG33748-PB,FlyBase:FBpp0099895,GB_protein:AAO41564.1,REFSEQ:NP_001027186,GB_protein:AAO41564,UniProt/Swiss-Prot:P82890,FlyMine:FBpp0099895,modMine:FBpp0099895; MD5=29895133e3b77b09876efddc4ee216f9; length=155; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 155 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA][NAS]
    Biological Process: protein amino acid dephosphorylation [ISS][NAS]
    Molecular Function: non-membrane spanning protein tyrosine phosphatase activity [IEA]
    protein tyrosine phosphatase activity [ISS][NAS]
    acid phosphatase activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRKVLMICL GNICRSPIAE VVMVDTLEKA NVKDVEVDSA AIGGWHVGNR ADPRAISTLQ  60
   61 KHGLKCTHIV RQIRKQDFSE FDYIFGMDED NMSELRRLAP KGSKAELLML GDFGLEKKNR 120
  121 IIEDPYYERG AEGFETAYQQ CVVACAAFMK ERLQK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 42.045757 CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  6.88246946508693 bayes_pls_golite062009
  • phosphatase activity
    		•  6.45415826301085 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.24793868976995 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  5.42677419561083 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.27901564747165 bayes_pls_golite062009
  • hydrolase activity
    		•  3.65742648154352 bayes_pls_golite062009
  • catalytic activity
    		•  1.99182579317454 bayes_pls_golite062009
  • binding
    		•  1.7522117458664 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.13529227602607 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.0484627589904 bayes_pls_golite062009
  • DNA binding
    		•  0.830124621163606 bayes_pls_golite062009
  • acid phosphatase activity
    		•  0.62303289859123 bayes_pls_golite062009
  • protein binding
    		•  0.332591807861153 bayes_pls_golite062009
  • transcription factor activity
    		•  0.195322993680513 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.67

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle