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Protein Overview: Men-PA

General Information:
Name(s) found: Men-PA / FBpp0082130 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Malic enzyme is referred to in FlyBase by the symbol Dmel\Men (CG10120, FBgn0002719). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8538819..8548267. It has the cytological map location 87C6-87C7. There is experimental evidence that it has the molecular function</span>: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction; malate metabolic process. 63 alleles are reported. The phenotype of these alleles is annotated with: eye. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: malate metabolic process [IEA]
    oxidation reduction [IEA]
    Molecular Function: NAD or NADH binding [IEA]
    metal ion binding [IEA]
    malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSILRRCSG IRKTFGPTPV YPTANNSQSP SSYSRGKERE LGCYTKRNSN SNNNNSHERE  60
   61 SQSCCSSRVC KNHTTTTTTT LEYELSNFAK LTTRITTQSA AEVDTSPHTD TETHRDRDSN 120
  121 PGNIALATDL ELPKGLPLSL SSRHHWNQLQ SSLHALHHQQ QQQQQQLRSY SSTSETNLED 180
  181 KMSKPDSKLD KYAQRDRLGL WGTGDNEVVG SLSGFTRLLD KRYSKGLAFT HEERQQLGIH 240
  241 GMLPYVVREP SEQVEHCRAL LARLDQDLDK YMYLISLSER NERLFYNVLS SDIAYMMPLV 300
  301 YTPTVGLACQ RYSLIHQNAK GMFISIKDKG HIYDVLKNWP ETDVRAIVVT DGERILGLGD 360
  361 LGANGMGIPV GKLSLYTALA GIKPSQCLPI TLDVGTNTES ILEDPLYIGL RERRATGDLY 420
  421 DEFIDEFMHA CVRRFGQNCL IQFEDFANAN AFRLLSKYRD SFCTFNDDIQ GTASVAVAGL 480
  481 LASLKIKKTQ LKDNTLLFLG AGEAALGIAN LCLMAMKVEG LTEEEAKARI WMVDSRGVIT 540
  541 RDRPKGGLTE HKLHFAQLHE PIDTLAEAVR KVRPNVLIGA AAQGGAFNQE ILELMADINE 600
  601 TPIIFALSNP TSKAECTAEE AYTYTKGRCI FASGSPFAPV TYNNKKFYPG QGNNSYIFPG 660
  661 VALGVLCAGM LNIPEQVFLV AAERLAELVS KDDLAKGSLY PPLSSIVSCS MAIAERIVEY 720
  721 AYKNGLATVR PEPVNKLAFI KAQMYDLDYP RSVPATYKM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..203] deduced N/A No confident structure predictions are available.
    2 View Details [204..759] PSI-BLAST 1000.0 Crystal structure of a human malic enzyme


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle