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Protein Overview: Adk3-PB, Adk3-PA...

General Information:
Name(s) found: FBpp0308470 [FlyBase]
FBpp0308469 [FlyBase]
Adk3-PA / FBpp0081807 [FlyBase]
Adk3-PB / FBpp0081806 [FlyBase]
Description(s) found:
Found 48 descriptions.
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  • type=protein; loc=3R:complement(6713382..6714032); ID=FBpp0308470; name=Adk3-PD; parent=FBgn0042094,FBtr0339379; dbxref=FlyBase:FBpp0308470,FlyBase_Annotation_IDs:CG6612-PD; MD5=cee07891528b7c4e7bd8b223295dcd57; length=216; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=3R:complement(6713382..6714032); ID=FBpp0308469; name=Adk3-PC; parent=FBgn0042094,FBtr0339378; dbxref=FlyBase:FBpp0308469,FlyBase_Annotation_IDs:CG6612-PC; MD5=cee07891528b7c4e7bd8b223295dcd57; length=216; release=r5.56; species=Dmel; [FlyBase]
  • The gene Adenylate kinase-3 is referred to in FlyBase by the symbol Dmel\Adk3 (CG6612, FBgn0042094). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6713288..6715310. It has the cytological map location 86C7. Based on sequence similarity, it is predicted to have molecular function</span>: nucleoside triphosphate adenylate kinase activity; adenylate kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: ADP biosynthetic process. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Adenylate kinase-3 is referred to in FlyBase by the symbol Dmel\Adk3 (CG6612, FBgn0042094). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6713288..6715310. It has the cytological map location 86C7. Based on sequence similarity, it is predicted to have molecular function</span>: nucleoside triphosphate adenylate kinase activity; adenylate kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: ADP biosynthetic process. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 216 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS]
    Biological Process: ADP biosynthetic process [ISS]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    Molecular Function: adenylate kinase activity [ISS][NAS]
    ATP binding [IEA]
    nucleoside triphosphate adenylate kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTKIFRAVI IGAPGSGKGT ISELICKNHG CVHISTGDIL RQNIIKNTEL GKKAKQYIAE  60
   61 GKLVPDAIVT KTMLARITEV GNRSYILDGF PRNIAQAEAL AAREQIDAVI TLDVPHSVII 120
  121 DRVKNRWIHA PSGRVYNIGF KNPKVPGKDD VTGEPLMQRE DDKPHVVAKR LELYDEVMSP 180
  181 VIAWYEKKGL VATFKGKQTK EIWPMMELFL NDRINA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] PSI-BLAST 50.69897 Adenylate kinase; Microbial and mitochondrial ADK, insert "zinc finger" domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  5.63633783771436 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  4.87013305162694 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  4.82340609517643 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  4.71956130169341 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.0949233879946 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.99447661719154 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.87925071606336 bayes_pls_golite062009
  • adenylate kinase activity
    		•  3.67594732794865 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.42302963379604 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.18231927518784 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.06199686145935 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.98215729643952 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.53142082854758 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.52938239070386 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.52887308780164 bayes_pls_golite062009
  • nucleotide binding
    		•  1.52746968836881 bayes_pls_golite062009
  • ATP binding
    		•  1.23942044024113 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.21044170258803 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.19481945569892 bayes_pls_golite062009
  • kinase activity
    		•  1.11120928120082 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • guanylate kinase activity
    		•  0.98934362137863 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  0.938652092720669 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.908046791062776 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.738234102557832 bayes_pls_golite062009
  • motor activity
    		•  0.68122766055454 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.635625372639205 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • CTP synthase activity
    		•  0.554689818807922 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.48522137429998 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.421921195209539 bayes_pls_golite062009
  • protein kinase activity
    		•  0.351308564667977 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • formate-tetrahydrofolate ligase activity
    		•  0.21533099279384 bayes_pls_golite062009
  • transferase activity
    		•  0.175269600441384 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  0.17485591642323 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0558641287316701 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle