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Protein Overview: Art1-PA

General Information:
Name(s) found: Art1-PA / FBpp0081780 [FlyBase]
Description(s) found:
Found 43 descriptions.
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  • The gene Arginine methyltransferase 1 is referred to in FlyBase by the symbol Dmel\Art1 (CG6554, FBgn0037834). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6612203..6613930. It has the cytological map location 86C6. There is experimental evidence that it has the molecular function</span>: protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; histone methyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: histone methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IDA]
    histone methylation [IDA]
    Molecular Function: protein-arginine omega-N asymmetric methyltransferase activity [IDA]
    histone methyltransferase activity [IDA]
    protein-arginine omega-N monomethyltransferase activity [IDA]
    protein-arginine N-methyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTDIPMEA AVESATGITP NSNANSNNVA KKLPAEGSTG DNPNANADEM TSRDYYFDSY  60
   61 AHFGIHEEML KDEVRTVTYR NAMYHNKHLF QGKTVLDVGC GTGILSMFAA KAGAAQVIAV 120
  121 DCSNIIEFAR QVVIDNNLQD VITVVKGKIE EIELPNGIEG VDIIISEWMG YCLFYESMLD 180
  181 TVLYARDKWL KKDGMMFPDR GTLYITAIED RQYKDEKINW WDDVYGFDMS CIRKVAVTEP 240
  241 LVDVVDPKQV VSTSCMVKEV DLYTVQKADL NFSSKFSLCI KRNDFVQALV TYFNIEFTKC 300
  301 HKRLGFSTSP DSTYTHWKQT VFYLDDHMTA KKNEEITGTF QMKPNERNNR DLDFVIDINF 360
  361 KGELSQIQES NTYRMR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..376] PSI-BLAST 85.69897 Structure of the Predominant protein arginine methyltransferase PRMT1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein-arginine N-methyltransferase activity
    		•  5.52520020727046 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  5.52520020727046 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  5.03267617653315 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  4.4632173842967 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  4.40911163698179 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  4.39379274790202 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  3.55785970363721 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.86617323549909 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  2.25250509433971 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • [myelin basic protein]-arginine N-methyltransferase activity
    		•  1.7438509457599 bayes_pls_golite062009
  • histone methyltransferase activity (H3-R2 specific)
    		•  1.49229188826344 bayes_pls_golite062009
  • histone methyltransferase activity (H2A-R3 specific)
    		•  1.49229188826344 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  1.48228631448092 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11388181877851 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11388181877851 bayes_pls_golite062009
  • binding
    		•  0.976078016260105 bayes_pls_golite062009
  • histone binding
    		•  0.964746527369069 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.858129308056814 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.858129308056814 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.858129308056814 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  0.817509452491588 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.237494224321778 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.230719796976667 bayes_pls_golite062009
  • DNA binding
    		•  0.22268909330347 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.103639608104023 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle