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Protein Overview: cwo-PA

General Information:
Name(s) found: cwo-PA / FBpp0081723 [FlyBase]
Description(s) found:
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  • gi|24645680|ref|NP_524775.1| CG17100 [Drosophila melanogaster] [NCBI NR]
  • gi|23170909|gb|AAF54527.2| CG17100 [Drosophila melanogaster] [NCBI NR]
  • The gene clockwork orange is referred to in FlyBase by the symbol Dmel\cwo (CG17100, FBgn0259938). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6213985..6226072. It has the cytological map location 86B3. There is experimental evidence that it has the molecular function</span>: transcription repressor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of circadian rhythm. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG17100-PA translation from_gene[CG17100 stich1 FBgn0016941] seq_release:3 mol_weight=75107 cds_boundaries:(3R:6,215,119..6,225,075[+]) aa_length:698 transcript_info:[CG17100-RA seq_release:3] gene_info:[gene symbol:stich1 FBgn0016941 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VGZ5) CG17100 protein [DrosMelano7227.FASTAC.txt]
  • CG17100-PA [Drosophila melanogaster]gi|24645680|ref|NP_524775.1| CG17100-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(6215101..6215159,6222419..6222542,6223085..6223406,6223469..6225060); ID=FBpp0081723; name=cwo-PA; parent=FBgn0259938,FBtr0082246; dbxref=FlyBase:FBpp0081723,FlyBase_Annotation_IDs:CG17100-PA,GB_protein:AAF54527.2,REFSEQ:NP_52477 [fly-100309-contam.fasta]
  • CG17100-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(6215101..6215159,6222419..6222542,6223085..6223406,6223469..6225060); ID=FBpp0081723; name=cwo-PA; parent=FBgn0259938,FBtr0082246; dbxref=FlyBase:FBpp0081723,FlyBase_Annotation_IDs:CG17100-PA,GB_protein:AAF54527.2,REFSEQ:NP_524775,GB_protein:AAF54527; MD5=f96d043f9ac82cbe4e7ebeddc9721567; length=698; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(6215101..6215159,6222419..6222542,6223085..6223406,6223469..6225060); ID=FBpp0081723; name=cwo-PA; parent=FBgn0259938,FBtr0082246; dbxref=FlyBase:FBpp0081723,FlyBase_Annotation_IDs:CG17100-PA,GB_protein:AAF54527.2,REFSEQ:NP_524775,GB_protein:AAF54527; MD5=f96d043f9ac82cbe4e7ebeddc9721567; length=698; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Clockwork orange OS=Drosophila melanogaster GN=cwo PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(6215101..6215159,6222419..6222542,6223085..6223406,6223469..6225060); ID=FBpp0081723; name=cwo-PA; parent=FBgn0259938,FBtr0082246; dbxref=FlyBase:FBpp0081723,FlyBase_Annotation_IDs:CG17100-PA,GB_protein:AAF54527.2,REFSEQ:NP_524775,GB_protein:AAF54527,FlyMine:FBpp0081723,modMine:FBpp0081723; MD5=f96d043f9ac82cbe4e7ebeddc9721567; length=698; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(10389379..10389437,10396697..10396820,10397363..10397684,10397747..10399338); ID=FBpp0081723; name=cwo-PA; parent=FBgn0259938,FBtr0082246; dbxref=FlyBase:FBpp0081723,FlyBase_Annotation_IDs:CG17100-PA,GB_protein:AAF54527.2,REFSEQ:NP_524775,GB_protein:AAF54527,FlyMine:FBpp0081723,modMine:FBpp0081723; MD5=f96d043f9ac82cbe4e7ebeddc9721567; length=698; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(10389379..10389437,10396697..10396820,10397363..10397684,10397747..10399338); ID=FBpp0081723; name=cwo-PA; parent=FBgn0259938,FBtr0082246; dbxref=FlyBase:FBpp0081723,FlyBase_Annotation_IDs:CG17100-PA,GB_protein:AAF54527.2,REFSEQ:NP_524775,GB_protein:AAF54527,FlyMine:FBpp0081723,modMine:FBpp0081723; MD5=f96d043f9ac82cbe4e7ebeddc9721567; length=698; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Clockwork orange, isoform A OS=Drosophila melanogaster GN=cwo PE=1 SV=2 [DROME.fasta.20160308]
  • FBpp0081723 type=protein; loc=3R:join(10389379..10389437,10396697..10396820,10397363..10397684,10397747..10399338); ID=FBpp0081723; name=cwo-PA; parent=FBgn0259938,FBtr0082246; dbxref=FlyBase:FBpp0081723,FlyBase_Annotation_IDs:CG17100-PA,GB_protein:AAF54527.2,REFSEQ:NP_524775,GB_protein:AAF54527,FlyMine:FBpp0081723,modMine:FBpp0081723; MD5=f96d043f9ac82cbe4e7ebeddc9721567; length=698; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(10389379..10389437,10396697..10396820,10397363..10397684,10397747..10399338); ID=FBpp0081723; name=cwo-PA; parent=FBgn0259938,FBtr0082246; dbxref=FlyBase:FBpp0081723,FlyBase_Annotation_IDs:CG17100-PA,GB_protein:AAF54527.2,REFSEQ:NP_524775,GB_protein:AAF54527,UniProt/TrEMBL:Q9VGZ5,FlyMine:FBpp0081723,modMine:FBpp0081723; MD5=f96d043f9ac82cbe4e7ebeddc9721567; length=698; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 698 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IEA][ISS]
    regulation of circadian rhythm [IMP]
    Molecular Function: DNA binding [IEA]
    RNA polymerase II transcription factor activity [NAS]
    transcription repressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPYWNETNG HAAHPVKYES EAAVSSFPYC TESSLNFSTS ATAYSEDDAE YATGRRNKTS  60
   61 RQDPLSHRII EKRRRDRMNS CLADLSRLIP PQYQRKGRGR IEKTEIIEMA IRHLKHLQSE 120
  121 CQQKESDYRS GYMDCMKEAA KFLYDVHMQD FCHRLLGRLQ EHIDEMFKTD CYKSTRSCHM 180
  181 PDNVSASSGS PHQAYHPPLC HLRDMLATSA SDVEHSQDHN DVKDLSFRNH LNQLQRSQQA 240
  241 AAAAAVAAAA VAVANGSSPA SNAGVDSKVP LTNGGGTGGA PPAADNVPSN STGSGSAAAC 300
  301 AGGNSNSSGS NSSNAASSTI CPPAGGSCPA KVTPLAAHQQ PHQAPVITST APHHHHHHTD 360
  361 SSHHDFESSR EPILHTDTSN MHSPPPRDLL LQQHPHLAHS HHTQDSLMSV RMRNYSESSH 420
  421 EIEHNNNYKY KNHIKERFVH ELHDEETSSE HCPVAAHLQS DHSHLQALSE HSKDGTEPEI 480
  481 APIMAKKRKL AEAAANGEIP LEVHTESSNA GASSANRLDK PSPSFNFSDI KDIKAELHNG 540
  541 NSNSSPLLAK LSAVAAAGGQ LSTPSSTTAP LPPRHTFTVP IFALHGQGNY YVPLNVDYNA 600
  601 LVPFLNGMDL LEKSYTSMPV VHPININVNF MPSSPSASLL AAAAAAAVAV GKQQQQQAVV 660
  661 AAGAGLPLST NSAAAQAAAV AAAAVAKAKL EQAMNQSW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] PSI-BLAST 15.30103 Usf B/HLH domain
    2 View Details [146..331] MSA 1.191993 View MSA. No confident structure predictions are available.
    3 View Details [332..473] deduced N/A No confident structure predictions are available.
    4 View Details [474..698] MSA 3.204996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.04189889011459 bayes_pls_golite062009
  • DNA binding
    		•  1.47769879162301 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.40297587472455 bayes_pls_golite062009
  • transcription factor activity
    		•  1.37196407054029 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.25065254420125 bayes_pls_golite062009
  • protein binding
    		•  0.90375176425983 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle