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View Structure Prediction Details

Protein: cwo-PA
Organism: Drosophila melanogaster
Length: 698 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cwo-PA.

Description E-value Query
Range
Subject
Range
FBpp0293681, FBp... - type=protein; loc=3R:join(6223133..6223406,6223469..6225060); ID=FBpp0293682; name=cwo-PC; parent=FB...
186.0 [0..78] [698..1]

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Predicted Domain #1
Region A:
Residues: [1-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPYWNETNG HAAHPVKYES EAAVSSFPYC TESSLNFSTS ATAYSEDDAE YATGRRNKTS  60
   61 RQDPLSHRII EKRRRDRMNS CLADLSRLIP PQYQRKGRGR IEKTEIIEMA IRHLKHLQSE 120
  121 CQQKESDYRS GYMDCMKEAA KFLYD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.30103
Match: 1an4A
Description: Usf B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.04189889011459 bayes_pls_golite062009
DNA binding 1.47769879162301 bayes_pls_golite062009
transcription regulator activity 1.40297587472455 bayes_pls_golite062009
transcription factor activity 1.37196407054029 bayes_pls_golite062009
nucleic acid binding 1.25065254420125 bayes_pls_golite062009
protein binding 0.90375176425983 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [146-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHMQDFCHRL LGRLQEHIDE MFKTDCYKST RSCHMPDNVS ASSGSPHQAY HPPLCHLRDM  60
   61 LATSASDVEH SQDHNDVKDL SFRNHLNQLQ RSQQAAAAAA VAAAAVAVAN GSSPASNAGV 120
  121 DSKVPLTNGG GTGGAPPAAD NVPSNSTGSG SAAACAGGNS NSSGSNSSNA ASSTICPPAG 180
  181 GSCPAK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [332-473]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTPLAAHQQP HQAPVITSTA PHHHHHHTDS SHHDFESSRE PILHTDTSNM HSPPPRDLLL  60
   61 QQHPHLAHSH HTQDSLMSVR MRNYSESSHE IEHNNNYKYK NHIKERFVHE LHDEETSSEH 120
  121 CPVAAHLQSD HSHLQALSEH SK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [474-698]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGTEPEIAPI MAKKRKLAEA AANGEIPLEV HTESSNAGAS SANRLDKPSP SFNFSDIKDI  60
   61 KAELHNGNSN SSPLLAKLSA VAAAGGQLST PSSTTAPLPP RHTFTVPIFA LHGQGNYYVP 120
  121 LNVDYNALVP FLNGMDLLEK SYTSMPVVHP ININVNFMPS SPSASLLAAA AAAAVAVGKQ 180
  181 QQQQAVVAAG AGLPLSTNSA AAQAAAVAAA AVAKAKLEQA MNQSW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle