Protein Overview: P58IPK-PA

General Information:
Name(s) found:	P58IPK-PA / FBpp0081552 [FlyBase]
Description(s) found: Found 21 descriptions. SHOW ALL	The gene P58IPK is referred to in FlyBase by the symbol Dmel\P58IPK (CG8286, FBgn0037718). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5412661..5415303. It has the cytological map location 85D27. Based on sequence similarity, it is predicted to have molecular function</span>: protein kinase inhibitor activity. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	498 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	heat shock protein binding [IEA] protein kinase inhibitor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALPLSDLLM IGGGEKKLAA CLVLLLLELF LEGAESTASP ADIENHLELG KEFLARGQLS  60
   61 DALTHYHAAV EGDANNYLTL FKRGTVYLAL GKTRFAVQDF SRVLELKPDF MAARIQRGVV 120
  121 HMKSGEYEQA IQDFDQVLQE EPNNGLVLEH YSRLAPAQEQ WVLVQQLIQY SDHQNAIPMI 180
  181 TQLLEISPWA VPFRQARSDA YIAINDPLLA IADLRQVNRL TQDSTEGHYK IAQLLYTIGH 240
  241 ATNALKEIRE CLKFDPEHKL CFPFYKKLRK VEKQLVNAEQ AREEKHFAEC IAAGEAVLRN 300
  301 EPEETMIRYE GHKVLCTCYT GDEQFGKALQ QCKEALDIMK DAQVYCDRAD ALLGTEMYDD 360
  361 AIHSFQAALD LEESNTRAKE GIQRAKKLQK QSERRDYYKI LGVKRSASKQ EIVKAYRKAA 420
  421 QKWHPDNFRD EEKKVAEKKF IDIAAAKEVL TDPEKRRQFD NGEDPLDPES NQRGGFHGEH 480
  481 PFGHFQHGSP FQFKFHFN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

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No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..391]	PSI-BLAST	54.69897	The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
2	View Details	[392..498]	PSI-BLAST	3.39794	NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
binding	2.07985546140154	bayes_pls_golite062009
protein binding	1.6279032205159	bayes_pls_golite062009
heat shock protein binding	1.35268080101836	bayes_pls_golite062009
unfolded protein binding	1.03065657981002	bayes_pls_golite062009
transcription regulator activity	0.921062221092247	bayes_pls_golite062009
nucleic acid binding	0.75712113503301	bayes_pls_golite062009
DNA binding	0.665813461397509	bayes_pls_golite062009
transferase activity	0.452898681502483	bayes_pls_golite062009
enzyme binding	0.44905827271946	bayes_pls_golite062009

2

Term	Confidence	Notes
unfolded protein binding	3.04403163860617	bayes_pls_golite062009
heat shock protein binding	2.17994194200939	bayes_pls_golite062009
binding	1.99149924818543	bayes_pls_golite062009
protein binding	1.60937254813642	bayes_pls_golite062009
chaperone binding	1.57325829043476	bayes_pls_golite062009
kinase activity	0.936554320686515	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.927839776089689	bayes_pls_golite062009
transcription regulator activity	0.872741968451597	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.827140997260646	bayes_pls_golite062009
nucleic acid binding	0.763540310856132	bayes_pls_golite062009
DNA binding	0.591517775901809	bayes_pls_golite062009
transferase activity	0.565700982733666	bayes_pls_golite062009
Hsp70 protein binding	0.541755903922701	bayes_pls_golite062009
protein kinase activity	0.36885370400914	bayes_pls_golite062009
protein serine/threonine kinase activity	0.132809854474755	bayes_pls_golite062009
catalytic activity	0.106988907594358	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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