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Protein Overview: Vps45-PA

General Information:
Name(s) found: Vps45-PA / FBpp0081548 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Vacuolar protein sorting 45 is referred to in FlyBase by the symbol Dmel\Vps45 (CG8228, FBgn0261049). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5389703..5391814. It has the cytological map location 85D25-85E. Based on sequence similarity, it is predicted to have molecular function</span>: SNARE binding. There is experimental evidence that it is involved in the biological process</span>: endosomal vesicle fusion; endocytosis. 7 alleles are reported. The phenotypes of these alleles are annotated with: posterior wing margin; wing vein. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 574 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [NAS]
    Biological Process: protein targeting [ISS]
    lysosome organization [ISS]
    synaptic vesicle priming [NAS]
    vesicle-mediated transport [ISS]
    vesicle docking during exocytosis [IEA]
    endosomal vesicle fusion [IMP]
    intracellular protein transport [ISS]
    endocytosis [IMP]
    neurotransmitter secretion [NAS]
    Molecular Function: SNARE binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLISGIKLY IEKMCSESGP GMKIILLDKE TTSIISMAFS QSDMLQREVY LFERLDSGRS  60
   61 NERLKYLKCI VFIRPTKQNI QLLANELRNP KYSAYYIYFS NIIPRTDIKY LAECDESESV 120
  121 REVKELYADY LCVNPNLFSL GIPNCMANLN WLPDALNRSM QGITAVLLSL KLNPVIRYRA 180
  181 GSQAAQLLAK LIYEQITKES SLFDFRSNMD GAAPPLLLVL DRRDDPVTPL LHQWTYQAMV 240
  241 HELLHIKNNR LDLSNCPNVP KDFKELVLSG DQDDFYGNNM YANYGEIGST IKQLMEEFQR 300
  301 KANDHKKVES IADMKNFIES YPQFKKMSGT VQKHLCVIGE LSALSNKRNL FEVSELEQEI 360
  361 ACKAEHSAQL QRIKKLIADE RVSIDDALKL VALYALRYER HANCDTSGLL QIIKTRGGRA 420
  421 AIVPSLIEYA GTHVRQGDLF NMVRITDAVK LTRNLIKGLK GVENVFTQHT PLLKETLEDV 480
  481 FKGRELDPLF PAINSELVPF RRPPQEVVVF IIGGATYEEA LAVHQLNNAG YKVILGGTTI 540
  541 HNSQSFIQEV VAATSGIQFK HTKSMIKYCS TDNI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..574] PSI-BLAST 137.0 Neuronal Sec1, NSec1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNARE binding
    		•  4.56428593085019 bayes_pls_golite062009
  • syntaxin binding
    		•  3.46044132736061 bayes_pls_golite062009
  • binding
    		•  2.7837022903231 bayes_pls_golite062009
  • protein binding
    		•  1.7224010512877 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.269372794919901 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle