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Protein Overview: alpha-Man-II-PA

General Information:
Name(s) found: alpha-Man-II-PA / FBpp0081509 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Ã?&#142;Ã?± Mannosidase II is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-II (CG18802, FBgn0011740). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5238271..5242986. It has the cytological map location 85D15-85D16. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid glycosylation. 7 alleles are reported. The phenotype of these alleles is annotated with: eye. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1108 amino acids

    Gene Ontology:
    Cellular Component: Golgi membrane [ISS][NAS]
    endoplasmic reticulum [NAS]
    Golgi stack [NAS]
    Biological Process: protein amino acid glycosylation [ISS]
    mannose metabolic process [IEA]
    protein amino acid N-linked glycosylation [NAS]
    Molecular Function: zinc ion binding [IEA]
    alpha-mannosidase activity [IEA]
    mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [ISS][NAS]
    carbohydrate binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRIRRRFAL VICSGCLLVF LSLYIILNFA APAATQIKPN YENIENKLHE LENGLQEHGE  60
   61 EMRNLRARLA ETSNRDDPIR PPLKVARSPR PGQCQDVVQD VPNVDVQMLE LYDRMSFKDI 120
  121 DGGVWKQGWN IKYDPLKYNA HHKLKVFVVP HSHNDPGWIQ TFEEYYQHDT KHILSNALRH 180
  181 LHDNPEMKFI WAEISYFARF YHDLGENKKL QMKSIVKNGQ LEFVTGGWVM PDEANSHWRN 240
  241 VLLQLTEGQT WLKQFMNVTP TASWAIDPFG HSPTMPYILQ KSGFKNMLIQ RTHYSVKKEL 300
  301 AQQRQLEFLW RQIWDNKGDT ALFTHMMPFY SYDIPHTCGP DPKVCCQFDF KRMGSFGLSC 360
  361 PWKVPPRTIS DQNVAARSDL LVDQWKKKAE LYRTNVLLIP LGDDFRFKQN TEWDVQRVNY 420
  421 ERLFEHINSQ AHFNVQAQFG TLQEYFDAVH QAERAGQAEF PTLSGDFFTY ADRSDNYWSG 480
  481 YYTSRPYHKR MDRVLMHYVR AAEMLSAWHS WDGMARIEER LEQARRELSL FQHHDGITGT 540
  541 AKTHVVVDYE QRMQEALKAC QMVMQQSVYR LLTKPSIYSP DFSFSYFTLD DSRWPGSGVE 600
  601 DSRTTIILGE DILPSKHVVM HNTLPHWREQ LVDFYVSSPF VSVTDLANNP VEAQVSPVWS 660
  661 WHHDTLTKTI HPQGSTTKYR IIFKARVPPM GLATYVLTIS DSKPEHTSYA SNLLLRKNPT 720
  721 SLPLGQYPED VKFGDPREIS LRVGNGPTLA FSEQGLLKSI QLTQDSPHVP VHFKFLKYGV 780
  781 RSHGDRSGAY LFLPNGPASP VELGQPVVLV TKGKLESSVS VGLPSVVHQT IMRGGAPEIR 840
  841 NLVDIGSLDN TEIVMRLETH IDSGDIFYTD LNGLQFIKRR RLDKLPLQAN YYPIPSGMFI 900
  901 EDANTRLTLL TGQPLGGSSL ASGELEIMQD RRLASDDERG LGQGVLDNKP VLHIYRLVLE 960
  961 KVNNCVRPSE LHPAGYLTSA AHKASQSLLD PLDKFIFAEN EWIGAQGQFG GDHPSAREDL1020
 1021 DVSVMRRLTK SSAKTQRVGY VLHRTNLMQC GTPEEHTQKL DVCHLLPNVA RCERTTLTFL1080
 1081 QNLEHLDGMV APEVCPMETA AYVSSHSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1108] PSI-BLAST 1000.0 Golgi alpha-mannosidase II in complex with kifunensine

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mannosidase activity
    		•  6.01915916767417 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  4.31715812247646 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.59000499388951 bayes_pls_golite062009
  • hydrolase activity
    		•  3.47408297144232 bayes_pls_golite062009
  • alpha-mannosidase activity
    		•  3.43578718881717 bayes_pls_golite062009
  • mannosyl-oligosaccharide mannosidase activity
    		•  2.67474348614438 bayes_pls_golite062009
  • deacetylase activity
    		•  2.13686837707321 bayes_pls_golite062009
  • binding
    		•  1.29644842078336 bayes_pls_golite062009
  • catalytic activity
    		•  1.17882014774774 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  1.00994109266252 bayes_pls_golite062009
  • racemase and epimerase activity, acting on carbohydrates and derivatives
    		•  0.68102716507433 bayes_pls_golite062009
  • mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
    		•  0.511393435253234 bayes_pls_golite062009
  • racemase and epimerase activity
    		•  0.473636146090495 bayes_pls_golite062009
  • protein binding
    		•  0.394432087623352 bayes_pls_golite062009
  • isomerase activity
    		•  0.106573908779409 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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