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Protein Overview: neur-PC, neur-PE

General Information:
Name(s) found: neur-PE / FBpp0289643 [FlyBase]
neur-PC / FBpp0081479 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene neuralized is referred to in FlyBase by the symbol Dmel\neur (CG11988, FBgn0002932). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4846068..4865189. It has the cytological map location 85C2-85C3. There is experimental evidence that it has the molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence for 16 unique biological process</span> terms, many of which group under: anatomical structure development; sensory organ development; organ development; organ morphogenesis; behavior; regulation of developmental process; regulation of biological process; locomotory behavior; regulation of neurogenesis; protein localization; neuromuscular process; behavioral interaction between organisms; response to chemical stimulus. 91 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: peripheral nervous system; adult segment; nervous system; embryonic nervous system; organ system; adult mesothoracic segment; external compound sense organ; embryonic glial cell; external sensory organ precursor cell; multi-cell-component structure. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • The gene neuralized is referred to in FlyBase by the symbol Dmel\neur (CG11988, FBgn0002932). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4846068..4865189. It has the cytological map location 85C2-85C3. There is experimental evidence that it has the molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence for 16 unique biological process</span> terms, many of which group under: anatomical structure development; sensory organ development; organ development; organ morphogenesis; behavior; regulation of developmental process; regulation of biological process; locomotory behavior; regulation of neurogenesis; protein localization; neuromuscular process; behavioral interaction between organisms; response to chemical stimulus. 91 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: peripheral nervous system; adult segment; nervous system; embryonic nervous system; organ system; adult mesothoracic segment; external compound sense organ; embryonic glial cell; external sensory organ precursor cell; multi-cell-component structure. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 672 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQSAGKIVR RSPSSCPGPN NLPPLQFHSV HGDNIRISRD GTLARRFESF CRAITFSARP  60
   61 VRINERICVK FAEISNNWNG GIRFGFTSND PVTLEGTLPK YACPDLTNRP GFWAKALHEQ 120
  121 YCEKDNILYY YVNGAGDVIY GINNEEKGVI LTGIDTRSLL WTVIDIYGNC TGIEFLDSRI 180
  181 YMYQQQPAAI PMATVPAQQQ QMPQPAANAS SALNSHHPHQ QSRRSLPGHT AAIEHDLERH 240
  241 VMPSLQSLHL AGNGGSVASV EQAAIAHDLA NGLPPLRYNA NGRLIPVPFH NTKGRNVRLS 300
  301 QDRFVASRTE SDFCQGYVFT ARPIRIGEKL IVQVLKTEQM YVGALALGLT SCNPAMLQPN 360
  361 DLPNDSDFLL DRPEYWVVSK DIAAAPQRGD EIAFFVAPNG EVSISKNNGP AVVVMHVDQS 420
  421 LQLWAFLDVY GSTQSLRMFR QQLPNMVAYP SQPQVNVNAS SSSACNAAST SRMLPMTESM 480
  481 SSLNAGATAK LLHHPSQLSV AQSTSTLASA GGVNGSRMIS MPSNGDILQI QPNGGGTVLV 540
  541 VNLPPASSSH DINGQLAARP TATVTSSGVL AGACSSGTLI STTSSQYIEQ PIANSTNNAA 600
  601 NKWKDSLSDQ QSTDSSAECT ICYENPIDSV LYMCGHMCMC YDCAIEQWRG VGGGQCPLCR 660
  661 AVIRDVIRTY TT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] PSI-BLAST 63.522879 No description for 2yueA was found.
    2 View Details [190..252] deduced N/A No confident structure predictions are available.
    3 View Details [253..419] FFAS03 7.15 No description for 2yueA was found.
    4 View Details [420..672] PSI-BLAST 17.39794 Cbl; N-terminal domain of cbl (N-cbl); CBL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • signal transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • receptor binding
    		•  1.52843393025918 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • transporter activity
    		•  0.751717017963896 bayes_pls_golite062009
  • protein complex binding
    		•  0.65988681496356 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.573179802647827 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.540818657754841 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.352421112301971 bayes_pls_golite062009
  • DNA binding
    		•  0.281643350069021 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.23313435855689 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.118606503254753 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.09784832072622 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0128369896420697 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle