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View Structure Prediction Details

Protein: neur-PC, neur-PE
Organism: Drosophila melanogaster
Length: 672 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for neur-PC, neur-PE.

Description E-value Query
Range
Subject
Range
neur-PA - The gene neuralized is referred to in FlyBase by the symbol Dmel\neur (CG11988, FBgn0002932). It is ...
gi|385741 - gi|385741|gb|AAB27147.1| C3HC4 zinc finger [Drosophila sp.]
601.0 [0..7] [672..89]

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Predicted Domain #1
Region A:
Residues: [1-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQSAGKIVR RSPSSCPGPN NLPPLQFHSV HGDNIRISRD GTLARRFESF CRAITFSARP  60
   61 VRINERICVK FAEISNNWNG GIRFGFTSND PVTLEGTLPK YACPDLTNRP GFWAKALHEQ 120
  121 YCEKDNILYY YVNGAGDVIY GINNEEKGVI LTGIDTRSLL WTVIDIYGNC TGIEFLDSRI 180
  181 YMYQQQPAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.522879
Match: 2yueA
Description: No description for 2yueA was found.

Predicted Domain #2
Region A:
Residues: [190-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPMATVPAQQ QQMPQPAANA SSALNSHHPH QQSRRSLPGH TAAIEHDLER HVMPSLQSLH  60
   61 LAG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [253-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGGSVASVEQ AAIAHDLANG LPPLRYNANG RLIPVPFHNT KGRNVRLSQD RFVASRTESD  60
   61 FCQGYVFTAR PIRIGEKLIV QVLKTEQMYV GALALGLTSC NPAMLQPNDL PNDSDFLLDR 120
  121 PEYWVVSKDI AAAPQRGDEI AFFVAPNGEV SISKNNGPAV VVMHVDQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 7.15
Match: 2yueA
Description: No description for 2yueA was found.

Predicted Domain #4
Region A:
Residues: [420-672]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLQLWAFLDV YGSTQSLRMF RQQLPNMVAY PSQPQVNVNA SSSSACNAAS TSRMLPMTES  60
   61 MSSLNAGATA KLLHHPSQLS VAQSTSTLAS AGGVNGSRMI SMPSNGDILQ IQPNGGGTVL 120
  121 VVNLPPASSS HDINGQLAAR PTATVTSSGV LAGACSSGTL ISTTSSQYIE QPIANSTNNA 180
  181 ANKWKDSLSD QQSTDSSAEC TICYENPIDS VLYMCGHMCM CYDCAIEQWR GVGGGQCPLC 240
  241 RAVIRDVIRT YTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 1fbvA
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.19631993182765 bayes_pls_golite062009
molecular transducer activity 3.13508395312263 bayes_pls_golite062009
signal transducer activity 3.13508395312263 bayes_pls_golite062009
binding 3.12724619324809 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
receptor binding 1.52843393025918 bayes_pls_golite062009
calcium ion binding 1.40919295397643 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
transporter activity 0.751717017963896 bayes_pls_golite062009
protein complex binding 0.65988681496356 bayes_pls_golite062009
transmembrane transporter activity 0.573179802647827 bayes_pls_golite062009
transcription regulator activity 0.540818657754841 bayes_pls_golite062009
nucleic acid binding 0.352421112301971 bayes_pls_golite062009
DNA binding 0.281643350069021 bayes_pls_golite062009
structural constituent of muscle 0.23313435855689 bayes_pls_golite062009
substrate-specific transporter activity 0.118606503254753 bayes_pls_golite062009
insulin receptor binding 0.09784832072622 bayes_pls_golite062009
cytoskeletal protein binding 0.0128369896420697 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle