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Protein Overview: CG18749-PB, FBpp...

General Information:
Name(s) found: FBpp0311483 [FlyBase]
CG18749-PB / FBpp0099996 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=3R:join(4071702..4071907,4071965..4072122,4072177..4072330,4072393..4073050,4073108..4073152,4073208..4073373,4073431..4073519); ID=FBpp0311483; name=CG18749-PC; parent=FBgn0042182,FBtr0345323; dbxref=FlyBase:FBpp0311483,FlyBase_Annotation_IDs:CG18749-PC; MD5=caab0cfb3b3b03cd5c9b24eaea2e4452; length=491; release=r5.56; species=Dmel; [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG18749 (CG18749, FBgn0042182). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4069781..4073577. It has the cytological map location 84F5-84F6. Based on sequence similarity, it is predicted to have molecular function</span>: procollagen-proline 4-dioxygenase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: peptidyl-proline hydroxylation to 4-hydroxy-L-proline. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 491 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEA]
    procollagen-proline 4-dioxygenase complex [IC]
    Biological Process: oxidation reduction [IEA]
    peptidyl-proline hydroxylation to 4-hydroxy-L-proline [ISS]
    Molecular Function: procollagen-proline 4-dioxygenase activity [ISS]
    L-ascorbic acid binding [IEA]
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [IEA]
    iron ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYILKKLTFI GFLSACFINC QGFVNSNPKK SYAASTMELM KLLEVEDELV DNLKGYVKTL  60
   61 KMKFNLMERS LIDMSRENME MKSDYESYLG NPLNSFRLIH RLHTSWRKWY QYAIKVENNA 120
  121 LGHIENARLM RKMLPTSSDL QQACRGIHDL MYFYDLKPEE LAAGNLAGYS QPGTGLTAYD 180
  181 CLALGEFGVQ NQKDDLAEAW YNLSLTRFDN IIEKYQVHKA WALLLAKNKQ LTEAFQHFEN 240
  241 KPEGIVASNE VIHFEGVLAT TQNCTAVVQK PSKKLHCRYN TSTTPFTRIA PLKMEELGLD 300
  301 PYMVVFHDVI YDTEIDGMLN SSDFGLSESV SGLKSEVRTS KDSHIVDAKT LNERVTDMTG 360
  361 LSMEMSDPFS LINYGLGGHF ILHHDFHEYT NTTRLKQGDR IATVLFYLRE VDSGGATVFP 420
  421 MLNITVMPKK GSAVFWYNLH NSGAVNSKTL HTACPVISGS KYVLTKWINE LPQMFVTPCM 480
  481 KDSNLRPPQK E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] Pfam 63.004365 No description for PF08336.2 was found. No confident structure predictions are available.
    2 View Details [171..284] PSI-BLAST 14.69897 Crystal structure of peptide-substrate-binding domain of human type I collagen prolyl 4-hydroxylase
    3 View Details [285..491] FFAS03 5.05 No description for 2hbtA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • procollagen-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  5.01373106146099 bayes_pls_golite062009
  • binding
    		•  2.14253214573541 bayes_pls_golite062009
  • protein binding
    		•  1.65083457326273 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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