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Protein Overview: Pbp95-PA

General Information:
Name(s) found: Pbp95-PA / FBpp0081282 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene PSEA-binding protein 95kD is referred to in FlyBase by the symbol Dmel\Pbp95 (CG2702, FBgn0037540). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:3839546..3842332. It has the cytological map location 84E8. There is experimental evidence that it has the molecular function</span>: bent DNA binding; protein binding; sequence-specific DNA binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: snRNA transcription from RNA polymerase III promoter; snRNA transcription from RNA polymerase II promoter; protein-DNA complex assembly. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 721 amino acids

    Gene Ontology:
    Cellular Component: snRNA-activating protein complex [IDA][IPI]
    Biological Process: protein-DNA complex assembly [IDA]
    snRNA transcription from RNA polymerase II promoter [IDA]
    snRNA transcription from RNA polymerase III promoter [IDA]
    regulation of transcription [IEA]
    Molecular Function: DNA binding [IDA]
    protein binding [IPI]
    sequence-specific DNA binding [IDA]
    bent DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDADDLRIN QQQLMDEISA LLQNTAKPSA ANALQLNQEL QRRLMQVRTK ILAMLQVVRA  60
   61 RFSRNEDILV RRLRPRSHFG PNSLNLSGAI LRKGTFRFKG NLFFRDIDGR SCPNNEDYEA 120
  121 RCHTEMFPTD FDMHSRHVWT LLDKKNVIMG IKQQLLEHRA HSTNALPSGS LKRKPIERHL 180
  181 STLVSLLATA DSSFSIDWNQ ISTLDLEYRH SPYSCEAMWR VYLTPDLRRD DWSPEEDETL 240
  241 LAVATANRMQ NWELIAASLD RRSDYQCFVR FHTALRFLLE PKNSHRWSEE DNDKLRAIVD 300
  301 RNTANSVINW KKVVEYFPDK SKSTLIGRYY YVLHPSISHE PFTTKEDMML FAAVEEYNGK 360
  361 FHCFPRSLFP NRSLTQLRTR YHNVLAQRNK TDSWSVQDDT RLMSFVTQYG ASQWLNCATF 420
  421 LGNHTRTSCR TRFLVIKKFL EQNPNAKVED LPRRRSKKVS LVNSDNWAQR LQEWQEDPES 480
  481 LVNDNPPKGT RVRGPKSKKA RIERQAESFS RLSKVDIEFC NFFKFSYNLT LSTPKTFPVP 540
  541 KDVYNLAYVI RALAYKPPIR PSLLQNIFMP NDVLKCYNSM IRNLPDEEGD MKSPLLPPNW 600
  601 STMMGFRALC ILSGDCRKDT ETRSFEYNES LPPIQLFRKR LQALFYRTTL LSRLESQLFT 660
  661 DLPSALVSLP RPKHDYAKMG THVELIDPEP APQNDLKSEP LSENEVINTV KQELEMEYTV 720
  721 P

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] PSI-BLAST 9.69897 c-Myb, DNA-binding domain
    2 View Details [152..232] deduced N/A No confident structure predictions are available.
    3 View Details [233..277] PSI-BLAST 11.522879 MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3
    4 View Details [278..444] PSI-BLAST 49.09691 c-Myb, DNA-binding domain
    5 View Details [445..554] deduced N/A No confident structure predictions are available.
    6 View Details [555..721] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.57523737355937 bayes_pls_golite062009
  • DNA binding
    		•  2.7565055095762 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.48097584527739 bayes_pls_golite062009
  • transcription factor activity
    		•  2.33198016659192 bayes_pls_golite062009
  • binding
    		•  2.21133851845856 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.14821760889085 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.37638337609693 bayes_pls_golite062009
  • protein binding
    		•  0.319330156880518 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.20862059645422 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.57523737355937 bayes_pls_golite062009
  • DNA binding
    		•  2.7565055095762 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.48097584527739 bayes_pls_golite062009
  • transcription factor activity
    		•  2.33198016659192 bayes_pls_golite062009
  • binding
    		•  2.21133851845856 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.14821760889085 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.37638337609693 bayes_pls_golite062009
  • protein binding
    		•  0.319330156880518 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.20862059645422 bayes_pls_golite062009
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  3.57523737355937 bayes_pls_golite062009
  • DNA binding
    		•  2.7565055095762 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.48097584527739 bayes_pls_golite062009
  • transcription factor activity
    		•  2.33198016659192 bayes_pls_golite062009
  • binding
    		•  2.21133851845856 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.14821760889085 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.37638337609693 bayes_pls_golite062009
  • protein binding
    		•  0.319330156880518 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.20862059645422 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle