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Protein Overview: Syt4-PA

General Information:
Name(s) found: Syt4-PA / FBpp0081097 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Synaptotagmin 4 is referred to in FlyBase by the symbol Dmel\Syt4 (CG10047, FBgn0028400). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:3091783..3096533. It has the cytological map location 84D3. It is reported to have molecular function</span>: calcium-dependent phospholipid binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: synaptic vesicle exocytosis. 8 alleles are reported. The phenotypes of these alleles are annotated with: neuromuscular junction; motor neuron. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 474 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [IEA][ISS]
    membrane [IEA]
    synapse part [IEP]
    plasma membrane [NAS]
    Biological Process: regulation of neurotransmitter secretion [IMP]
    vesicle-mediated transport [NAS]
    regulation of synaptic plasticity [IMP]
    synaptic vesicle exocytosis [ISS]
    neurotransmitter secretion [NAS]
    Molecular Function: transporter activity [IEA]
    calcium-dependent phospholipid binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEEYIPDAS VMDTIVPAIL GLTAAAVLSS VACICARQMR LRNKKQSQHD ASFPFQPTRR  60
   61 PTAVRSPSGQ PPHYLKKSPS PTGGKQMGLL SPMQDQSTSP IAQPNVKYSE EGDGPAQHAE 120
  121 QQNGNQLTVV DGNGLKHSLH NSLHHSPVET IANGSVTITL DDHSLTNGKE LTVTDQYGKL 180
  181 GTIYFKLRYL AERNALMVSI IRCRGLPCKG GSSGTGDIPT GMNGRTQAAT DPYVKLQLLP 240
  241 DKQHKVKTRV VRNTRNPVYD EDFTFYGLNM NDLQNMSLHF VILSFDRYSR DDVIGEVVCP 300
  301 LTSIEIGDIS KEALSISKEI QPRSLKIRAQ GRGELLISLC WQPAAGRLTV VLLKARNLPR 360
  361 MDVTGLADPY VKIYLLYNGQ RIAKKKTHVK KRTLSPVFNE SFAFDIPAAE GAGASLEGVS 420
  421 LELMLLDWDR VTKNEVIGRL ELGGPNSSST ALNHWNEVCN SPRRQIAEWH KLNE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] FFAS03 1.07 Solution NMR Structure of the Membrane Protein Stannin
    2 View Details [84..178] PSI-BLAST 5.39794 NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
    3 View Details [179..474] PSI-BLAST 70.09691 Synaptogamin I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.16347270289353 bayes_pls_golite062009
  • protein binding
    		•  1.19117920066014 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07277438393187 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07277438393187 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.598251633160064 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.578046214771465 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.225436367274486 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.224266644517051 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.0251407403506928 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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