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Protein Overview: lap-PA

General Information:
Name(s) found: lap-PA / FBpp0081091 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene like-AP180 is referred to in FlyBase by the symbol Dmel\lap (CG2520, FBgn0086372). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:3012719..3026631. It has the cytological map location 84D1-84D2. Based on sequence similarity, it is predicted to have molecular function</span>: phosphatidylinositol binding; clathrin binding. There is experimental evidence that it is involved in the biological process</span>: phototaxis; synaptic transmission; nerve-nerve synaptic transmission; receptor-mediated endocytosis; synaptic vesicle endocytosis. 16 alleles are reported. The phenotypes of these alleles are annotated with: eye; ommatidium; synaptic vesicle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 468 amino acids

    Gene Ontology:
    Cellular Component: clathrin coat [IEA]
    coated pit [IDA]
    synaptic vesicle [TAS]
    clathrin adaptor complex [ISS][NAS]
    Biological Process: nerve-nerve synaptic transmission [IMP]
    synaptic vesicle transport [TAS]
    synaptic vesicle endocytosis [IMP]
    synaptic vesicle coating [TAS]
    clathrin coat assembly [IEA]
    synaptic transmission [IMP]
    phototaxis [IMP]
    receptor-mediated endocytosis [IDA]
    neurotransmitter secretion [NAS]
    Molecular Function: clathrin binding [ISS][NAS]
    phosphatidylinositol binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMAGQTIND RLLAARHSLA GQGLAKSVCK ATTEECIGPK KKHLDYLVHC TNEPNVSIPH  60
   61 LANLLIERSQ NANWVVVYKS LITTHHLMAY GNERFMQYLA SSNSTFNLSS FLDKGTVQDG 120
  121 GMGVPGGRMG YDMSPFIRRY AKYLNEKSLS YRAMAFDFCK VKRGKEEGSL RSMNAEKLLK 180
  181 TLPVLQAQLD ALLEFDCQSN DLSNGVINMS FMLLFRDLIR LFACYNDGII NLLEKYFDMN 240
  241 KKHARDALDL YKKFLVRMDR VGEFLKVAEN VGIDKGDIPD LTKAPSSLLD ALEQHLATLE 300
  301 GRKVSAANTP TQSSSSAFGT AAASSKFDTT NGIDEQLKAQ VLAEEEAAMN QYKSKVSSPT 360
  361 SSGAAGASAA LTNPFLSSPP AAQAGQPIVD LFGAASAQPA AAAAATKASD DLLQLGNPFA 420
  421 DMFDASGGGA AAVGATGNAG DGTAKYDGGA GSSPFDWGAT DDDGGAAQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..303] PSI-BLAST 98.09691 AP180 (Lap)
    2 View Details [304..468] MSA 15.271997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  7.05477548709703 bayes_pls_golite062009
  • binding
    		•  2.29441263408582 bayes_pls_golite062009
  • protein binding
    		•  1.66643874221425 bayes_pls_golite062009
  • phospholipid binding
    		•  1.38798066582556 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.26458267960741 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.29600232011816 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle