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View Structure Prediction Details

Protein: lap-PA
Organism: Drosophila melanogaster
Length: 468 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lap-PA.

Description E-value Query
Range
Subject
Range
gi|44888288 - gi|44888288|sp|Q9VI75|PICA_DROME Phosphatidylinositol-binding clathrin assembly protein LAP (Like-AP...
430.0 [0..1] [468..1]

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Predicted Domain #1
Region A:
Residues: [1-303]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMAGQTIND RLLAARHSLA GQGLAKSVCK ATTEECIGPK KKHLDYLVHC TNEPNVSIPH  60
   61 LANLLIERSQ NANWVVVYKS LITTHHLMAY GNERFMQYLA SSNSTFNLSS FLDKGTVQDG 120
  121 GMGVPGGRMG YDMSPFIRRY AKYLNEKSLS YRAMAFDFCK VKRGKEEGSL RSMNAEKLLK 180
  181 TLPVLQAQLD ALLEFDCQSN DLSNGVINMS FMLLFRDLIR LFACYNDGII NLLEKYFDMN 240
  241 KKHARDALDL YKKFLVRMDR VGEFLKVAEN VGIDKGDIPD LTKAPSSLLD ALEQHLATLE 300
  301 GRK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.09691
Match: 1hx8A
Description: AP180 (Lap)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 7.05477548709703 bayes_pls_golite062009
binding 2.29441263408582 bayes_pls_golite062009
protein binding 1.66643874221425 bayes_pls_golite062009
phospholipid binding 1.38798066582556 bayes_pls_golite062009
phosphoinositide binding 1.26458267960741 bayes_pls_golite062009
protein domain specific binding 0.29600232011816 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [304-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSAANTPTQS SSSAFGTAAA SSKFDTTNGI DEQLKAQVLA EEEAAMNQYK SKVSSPTSSG  60
   61 AAGASAALTN PFLSSPPAAQ AGQPIVDLFG AASAQPAAAA AATKASDDLL QLGNPFADMF 120
  121 DASGGGAAAV GATGNAGDGT AKYDGGAGSS PFDWGATDDD GGAAQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle