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Protein Overview: plx-PA

General Information:
Name(s) found: plx-PA / FBpp0291300 [FlyBase]
Description(s) found:
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  • gi|7296688|gb|AAF51967.1| pollux, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|24644376|ref|NP_730988.1| pollux, isoform A [Drosophila melanogaster] [NCBI NR]
  • The gene pollux is referred to in FlyBase by the symbol Dmel\plx (CG42612, FBgn0261261). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1511854..1538559. It has the cytological map location 83B9-83C1. There is experimental evidence that it has the molecular function</span>: integrin binding. There is experimental evidence that it is involved in the biological process</span>: cell adhesion mediated by integrin. 12 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval tracheal system. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG1093-PA translation from_gene[CG1093 plx FBgn0004879] seq_release:3 mol_weight=154336 cds_boundaries:(3R:1,532,903..1,537,672[+]) aa_length:1379 transcript_info:[CG1093-RA seq_release:3] gene_info:[gene symbol:plx FBgn0004879 gene_boundaries:(3R:1,5 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VNG9) PLX protein [DrosMelano7227.FASTAC.txt]
  • (AE003602) plx gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG1093-PA, isoform A [Drosophila melanogaster]gi|24644376|ref|NP_730988.1| CG1093-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(1532906..1533663,1533743..1533904,1534221..1535108,1535164..1535306,1535366..1535958,1536016..1536585,1536653..1537678); ID=FBpp0078367; name=plx-PA; parent=FBgn0004879,FBtr0078718; dbxref=FlyBase:FBpp0078367,FlyBase_Annotation_I [fly-100309-contam.fasta]
  • pollux CG1093-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1093-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(1532906..1533663,1533743..1533904,1534221..1535108,1535164..1535306,1535366..1535958,1536016..1536585,1536653..1537678); ID=FBpp0078367; name=plx-PA; parent=FBgn0004879,FBtr0078718; dbxref=FlyBase:FBpp0078367,FlyBase_Annotation_IDs:CG1093-PA,GB_protein:AAF51967.1,REFSEQ:NP_730988,GB_protein:AAF51967; MD5=c1e4f8ad4baddf78fb43ff3e0cc37e91; length=1379; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(1532906..1533663,1533743..1533904,1534221..1535108,1535164..1535306,1535366..1535958,1536016..1536585,1536653..1537678); ID=FBpp0291300; name=plx-PA; parent=FBgn0261261,FBtr0302090; dbxref=FlyBase_Annotation_IDs:CG42612-PA,FlyBase:FBpp0291300,FlyBase:FBpp0078367,FlyBase_Annotation_IDs:CG1093-PA; MD5=c1e4f8ad4baddf78fb43ff3e0cc37e91; length=1379; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Pollux, isoform A OS=Drosophila melanogaster GN=plx PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(1532906..1533663,1533743..1533904,1534221..1535108,1535164..1535306,1535366..1535958,1536016..1536585,1536653..1537678); ID=FBpp0291300; name=plx-PA; parent=FBgn0261261,FBtr0302090; dbxref=REFSEQ:NP_730988,GB_protein:AAF51967,FlyBase_Annotation_IDs:CG42612-PA,FlyBase:FBpp0291300,FlyBase:FBpp0078367,FlyBase_Annotation_IDs:CG1093-PA,FlyMine:FBpp0291300,modMine:FBpp0291300; MD5=c1e4f8ad4baddf78fb43ff3e0cc37e91; length=1379; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(5707184..5707941,5708021..5708182,5708499..5709386,5709442..5709584,5709644..5710236,5710294..5710863,5710931..5711956); ID=FBpp0291300; name=plx-PA; parent=FBgn0261261,FBtr0302090; dbxref=REFSEQ:NP_730988,GB_protein:AAF51967,FlyBase_Annotation_IDs:CG42612-PA,FlyBase:FBpp0291300,FlyBase:FBpp0078367,FlyBase_Annotation_IDs:CG1093-PA,FlyMine:FBpp0291300,modMine:FBpp0291300; MD5=c1e4f8ad4baddf78fb43ff3e0cc37e91; length=1379; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(5707184..5707941,5708021..5708182,5708499..5709386,5709442..5709584,5709644..5710236,5710294..5710863,5710931..5711956); ID=FBpp0291300; name=plx-PA; parent=FBgn0261261,FBtr0302090; dbxref=REFSEQ:NP_730988,GB_protein:AAF51967,FlyBase_Annotation_IDs:CG42612-PA,FlyBase:FBpp0291300,FlyBase:FBpp0078367,FlyBase_Annotation_IDs:CG1093-PA,FlyMine:FBpp0291300,modMine:FBpp0291300; MD5=c1e4f8ad4baddf78fb43ff3e0cc37e91; length=1379; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of E1JJ52, Pollux, isoform A OS=Drosophila melanogaster GN=plx PE=4 SV=1 [DROME.fasta.20160308]
  • FBpp0291300 type=protein; loc=3R:join(5707184..5707941,5708021..5708182,5708499..5709386,5709442..5709584,5709644..5710236,5710294..5710863,5710931..5711956); ID=FBpp0291300; name=plx-PA; parent=FBgn0261261,FBtr0302090; dbxref=REFSEQ:NP_730988,GB_protein:AAF51967,FlyBase_Annotation_IDs:CG42612-PA,FlyBase:FBpp0291300,FlyBase:FBpp0078367,FlyBase_Annotation_IDs:CG1093-PA,FlyMine:FBpp0291300,modMine:FBpp0291300; MD5=c1e4f8ad4baddf78fb43ff3e0cc37e91; length=1379; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(5707184..5707941,5708021..5708182,5708499..5709386,5709442..5709584,5709644..5710236,5710294..5710863,5710931..5711956); ID=FBpp0291300; name=plx-PA; parent=FBgn0261261,FBtr0302090; dbxref=REFSEQ:NP_730988,GB_protein:AAF51967,FlyBase_Annotation_IDs:CG42612-PA,FlyBase:FBpp0291300,FlyBase:FBpp0078367,FlyBase_Annotation_IDs:CG1093-PA,UniProt/TrEMBL:Q9VNG9,FlyMine:FBpp0291300,modMine:FBpp0291300; MD5=c1e4f8ad4baddf78fb43ff3e0cc37e91; length=1379; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1379 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    cell surface [IDA]
    Biological Process: cell adhesion mediated by integrin [IDA]
    regulation of Rab GTPase activity [IEA]
    Molecular Function: Rab GTPase activator activity [IEA]
    integrin binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAELMHQMRD PAHTLGGSVG SIPQTLIGGG GGSHGNSNGA LNGIHATPAT NLKMSEAMRN  60
   61 AQHDTSPNPV SSKMKASKSY THGLSSSSGT VNIPTSTSAQ SNLSLLADIS PNHTHFFEVM 120
  121 YVGKIRVSQK RVPNTFIDDA LPKFKAYDAQ RLRLLQNRKM SLSSEGGVGI EAKPSSSLKS 180
  181 HDLKEEDEEE QEQHKGHDDS QDSQAKPLVQ LQLTGAEEGA APRPLEDNKE NKSPEKRPLL 240
  241 RGQSQIELGH KEHSDGSQPL AANSQLEAPN VIVNKQPTPP RDQGVGTGTA SASAGPSQLH 300
  301 PNYAMDNIPK QRDRSASQGC IPPYVEQNRT MVFLVGRCDL RLISPDRKQV LLYKDFKDVA 360
  361 SCVHGQKSLD HFGIICRELN NDGYIGYVFK CQSEHVCDDI VAAIAQAFDT CAEQKKKQDT 420
  421 QIFSCEHCPM LWYHKLCTDV EGLSEKKTQA LILRRIETLS DDEQEIVWAK FCGSEKTNSP 480
  481 VAEQNQFLMM LLRAHCESRQ QRHVHDTAEN RSEFLNQYLG GSTIFMKAKR SLTNSFDNLL 540
  541 KRKPSKDDIA VPSHNLRDIR EGSAEPLGTQ SPPEGFRSRS NTVGASPSSK PTAEQLKSPM 600
  601 MDIFIKVGNS PKEAETHQGS WRQAILNSVV TPSKGLDSEV PTEFLSPMRK PAKRGKRDAA 660
  661 ELRELWRTAI RQTIMLNRME TENAMLQARQ NENELKRIKL DYEEIVPCDK QLIERWEQII 720
  721 ERNSTQIGNK KDPKVLGHAI RTGVPRSKRG DVWTFLAEQH SMNTAPVDTK RFPNFNTPYH 780
  781 MLLKHLTEHQ HAIFIDLGRT FPNHQFYKDP LGLGQLSLFN LLKAYSILDP ELGYCQGLGF 840
  841 ICGVLLLHCD EANSFQLLKH LMFRRNMRTK YLPDMKKFQL QLYQLSRLVK DHLPDLYVWL 900
  901 DQNDVSPTLY AAPWILTVFS SQFPLGFVAR VFDLLFLESS DVIFKFAIAL LSVHKQQLLA 960
  961 KDNFEEIMDY LKTVVPKMEH TCMEQIMKLV FSMDIGKQLA EYKVEYNVLQ EEITTTNHHL1020
 1021 EMLNREKTQN QHLEQQLQFA QSSIAQLETT RSSQQAQITT LQSQVQSLEL TIQTLGRYVG1080
 1081 QLVEHNPDLE LPNEVRRMLQ QLDDLDRQRR KPIFTERKIG KSVSVNSHLG FPLKVLEELT1140
 1141 ERDELGSPQK QKKEKTPFFE QLRQQQQQHR LNGGGQSSNV GESGSPTPPS RPNRLLDNAS1200
 1201 ARTVMQVKLD ELKLPEHVDK FVANIKSPLE VDSGVGTPLS PPSTASNSSG GSIFSRMGYR1260
 1261 TTPPALSPLA QRQSYGVAIT TAPCPQHMEE VAPATTMAVM PQEDVEEPQP MHPLSMVGGD1320
 1321 VNVRFKGTTQ LKSIRPVHHM RAIPLGGVQH PSSTEPAVRV APVPVELAPP AATATTGRS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..252] deduced N/A No confident structure predictions are available.
    2 View Details [253..459] PSI-BLAST 39.39794 Solution structure of phosphotyrosine interaction domain of mouse Numb protein
    3 View Details [460..648] deduced N/A No confident structure predictions are available.
    4 View Details [649..799] PSI-BLAST 47.522879 No description for 2qq8A was found.
    5 View Details [800..1379] PSI-BLAST 12.522879 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.80647115437685 bayes_pls_golite062009
  • protein binding
    		•  2.79653072286066 bayes_pls_golite062009
  • receptor binding
    		•  1.48661693834572 bayes_pls_golite062009
  • receptor activity
    		•  0.391883623216444 bayes_pls_golite062009
  • enzyme binding
    		•  0.226557034609674 bayes_pls_golite062009
  • integrin binding
    		•  0.12314226569467 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.0178665883346718 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle