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Protein Overview: MED27-PA

General Information:
Name(s) found: MED27-PA / FBpp0078361 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Mediator complex subunit 27 is referred to in FlyBase by the symbol Dmel\MED27 (CG1245, FBgn0037359). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1480867..1482060. It has the cytological map location 83B8. Based on sequence similarity, it is predicted to have molecular function</span>: transcription cofactor activity; RNA polymerase II transcription mediator activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 293 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    mediator complex [IDA][ISS]
    Biological Process: transcription from RNA polymerase II promoter [ISS]
    transcription initiation from RNA polymerase II promoter [ISS]
    regulation of transcription from RNA polymerase II promoter [IC]
    Molecular Function: transcription cofactor activity [ISS]
    RNA polymerase II transcription mediator activity [IC][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLNSTLTA VKNLRSNVRL CFEHLADGTD GESGEESRNK FVNDFQERFA AINSQIREVE  60
   61 QLINGLPVPP TPYSLGNTAY LAQETSQDRQ ALYPQLVNSY KWMDKVHDHS FLAFNNLNQN 120
  121 TLRRSYNYCS QKRQRLPFSS FNNDPDHIDK LLSEINTPPH TSYRIFRPFG TNAVTIVTIS 180
  181 NVMKAAIVFK GVLIEWVTVK GFDEPLEHDD LWAESRYEVF RKVQDHAHSA MLHFFSPTLP 240
  241 DLAVKSYITW LNSHVKLFLE PCKRCGKFVV NGLPPTWRDL RTLEPFHEDC RNC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] MSA 2.010981 View MSA. Confident ab initio structure predictions are available.
    2 View Details [107..204] deduced N/A No confident structure predictions are available.
    3 View Details [205..293] MSA 2.010988 View MSA. Confident ab initio structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle