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Protein Overview: tacc-PA

General Information:
Name(s) found: tacc-PA / FBpp0088894 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene transforming acidic coiled-coil protein is referred to in FlyBase by the symbol Dmel\tacc (CG9765, FBgn0026620). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:560134..574777. It has the cytological map location 82D2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: protein localization; pronuclear migration; mitosis; microtubule cytoskeleton organization; nuclear migration. 29 alleles are reported. The phenotypes of these alleles are annotated with: pronucleus; mitotic cell cycle; centrosome; spindle; microtubule; astral microtubule; pericentriolar material; aster. It has 10 annotated transcripts and 10 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1226 amino acids

    Gene Ontology:
    Cellular Component: pericentriolar material [NAS]
    spindle microtubule [TAS]
    centrosome [IDA][TAS]
    spindle pole [IDA]
    astral microtubule [TAS]
    Biological Process: pronuclear migration [IMP]
    female meiosis [TAS]
    mitotic spindle organization [TAS]
    nuclear migration [IMP]
    pronuclear fusion [TAS]
    protein localization [IMP][TAS]
    negative regulation of microtubule depolymerization [NAS][TAS]
    mitosis [IMP][NAS]
    microtubule cytoskeleton organization [IMP]
    Molecular Function: protein binding [IPI]
    microtubule binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEFDDAENGL GMGFGGRGVL REINKNDGGI KLSPLAVKPS PKPTSMDQQK AMAAALGHQT  60
   61 AVPGGLKPED DLVPKFGGLP EFDETQIPEL APLSTDMDTQ LKSNHSDSDV FVECLSLHSE 120
  121 RYTGDRSELE AYSSALNDVL EQQLSMTSVS TLGAEFNDPL AVSQHNNVSY EAMDVDDLNE 180
  181 TMEMLKDVLN AEDRHLMQTH ILSVTQSKPE NNFVHYHPNQ EQNRVELDQL AKHSKPNSDA 240
  241 KESESLVESV LSEESGTQSF EPKLTLSALD STKDLAKHQE EMQTNTKDIF QKEKHHPVSS 300
  301 AQVKDAQNPK EPEKALNLKE ASSELSTKSA KSLEYPNQEK QFSVAVESME RPCTAISLEQ 360
  361 NASPAMEATE DRTVEELDQM DVDESMKVDD ATVLNSCRQE QINAHSPVSS KFFLKLCVQN 420
  421 DTDCQDNKMD QKTAGKESAL KMTEIELPVE SVPSASLSPP TPALQAKIIE LSLSPPIPTH 480
  481 RPKTAEELEF LALRELPLPD GVSTAGKVEC KQLSHGLVPI VAVLPTPLYL DLKGNTTTAS 540
  541 LPEPTSPSFP IKEPAEKQSH FPRSPRAQLE QKDMPYLEEA VVERSSHRKQ SDFGVIAKSP 600
  601 IVFELTQPSP EKQHLNETLP MSEISPTSSN MTFDSGSITE DKSQKGTENI EPSSTLAVSL 660
  661 GSVDDKQRRT FSVVQPTKEE EEAKSRRTFC MENENPRRTF CMQQNASPAV EATEDTGADE 720
  721 VMDVDISMRA DEVAVMKSHQ QTWKERQAPI SNSPPIPTHQ RLNRPPEAIS PVSPLGNGTV 780
  781 VLEEQTLSAK EQATLSASDE KDDVFLEHFG AISPVSDDMF KTSSASNNQA KFRVNADEET 840
  841 GGKGASAMIR KRSGTAGEQE EIFDAEFHDG VNNQNLILNS SDFDYLYTKG SNSVPIDRSS 900
  901 LLLKFDPLLG APVPVNHPNQ QEQALQNILG SNQHQNRLLS PTLEEHETSD GNQSFGVISS 960
  961 AKDTAKKWDF KPPVDRTKHV KMSVDVIDND CNKTFDNSNT NTEDKTHNYN DMDELEKKIK1020
 1021 NEVTRSEDIE KKLKEGELRE EALIKRITEK DKTNAKLNGV IEAYEKAIAE LISEKEQQAQ1080
 1081 LHERQLQEVQ ADRDANYHHL TSLETTFSDL HVKYEKSKEM TSQLKSNEES LLAERKQMMD1140
 1141 NLRLQEQRYD KMKNHAMQQL EIANKKLDTY SREHADETKK LKALLKKEEI SRVSMTEQLQ1200
 1201 QKSRENADLL KICEELIYGK GQGGSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] MSA 1.265997 View MSA. No confident structure predictions are available.
    2 View Details [186..276] deduced N/A No confident structure predictions are available.
    3 View Details [277..383] deduced N/A No confident structure predictions are available.
    4 View Details [384..622] deduced N/A No confident structure predictions are available.
    5 View Details [623..787] deduced N/A No confident structure predictions are available.
    6 View Details [788..1226] PSI-BLAST 14.09691 Heavy meromyosin subfragment


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle