Protein Overview: polo-PB, polo-PA

General Information:
Name(s) found:	polo-PB / FBpp0099722 [FlyBase] polo-PA / FBpp0074608 [FlyBase]
Description(s) found: Found 35 descriptions. SHOW ALL	The gene polo is referred to in FlyBase by the symbol Dmel\polo (CG12306, FBgn0003124). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:20303105..20306566. It has the cytological map location 77B2-77B3. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity; SUMO binding; protein kinase activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: cell cycle; cell cycle process; M phase of meiotic cell cycle; organelle organization; fertilization; transport; pronuclear migration; sperm aster formation; pronuclear fusion; regulation of neurogenesis. 35 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: organ system; anatomical structure; germarium; nucleus; intracellular membrane-bounded organelle; nuclear part; cytoplasmic part; egg; spindle; nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene polo is referred to in FlyBase by the symbol Dmel\polo (CG12306, FBgn0003124). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:20303105..20306566. It has the cytological map location 77B2-77B3. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity; SUMO binding; protein kinase activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: cell cycle; cell cycle process; M phase of meiotic cell cycle; organelle organization; fertilization; transport; pronuclear migration; sperm aster formation; pronuclear fusion; regulation of neurogenesis. 35 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: organ system; anatomical structure; germarium; nucleus; intracellular membrane-bounded organelle; nuclear part; cytoplasmic part; egg; spindle; nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	576 amino acids
Gene Ontology:
Cellular Component:	centrosome [IDA] cytoplasm [IDA][NAS] spindle [IDA] spindle pole [IDA] kinetochore [IDA] midbody [IDA] outer kinetochore of condensed chromosome [IDA][NAS]
Biological Process:	sperm aster formation [IMP] pronuclear migration [IMP] male meiosis chromosome segregation [TAS] female meiosis [IMP] male meiosis [IMP] mitotic spindle organization [IMP] spindle assembly involved in female meiosis II [IMP] pronuclear fusion [IMP] protein localization [NAS] cytokinesis [TAS] female meiosis II [IMP] mitosis [IMP][NAS] protein amino acid phosphorylation [IEA][NAS] cell cycle [IMP] phagocytosis, engulfment [IMP] negative regulation of neuroblast proliferation [IMP]
Molecular Function:	polo kinase kinase activity [IEA] ATP binding [IEA] SUMO binding [IPI] protein kinase activity [IDA][NAS] protein serine/threonine kinase activity [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAKPEDKST DIPDRLVDIN QRKTYKRMRF FGKGGFAKCY EIIDVETDDV FAGKIVSKKL  60
   61 MIKHNQKEKT AQEITIHRSL NHPNIVKFHN YFEDSQNIYI VLELCKKRSM MELHKRRKSI 120
  121 TEFECRYYIY QIIQGVKYLH DNRIIHRDLK LGNLFLNDLL HVKIGDFGLA TRIEYEGERK 180
  181 KTLCGTPNYI APEILTKKGH SFEVDIWSIG CVMYTLLVGQ PPFETKTLKD TYSKIKKCEY 240
  241 RVPSYLRKPA ADMVIAMLQP NPESRPAIGQ LLNFEFLKGS KVPMFLPSSC LTMAPRIGSN 300
  301 DTIEDSMHRK PLMEMNGIRP DDTRLESTFL KANLHDAITA SAQVCRHSED YRSDIESLYQ 360
  361 QLTNLINGKP RILQGNLGDE NTDPAAQPLF WISKWVDYSD KYGFGYQLCD EGIGVMFNDT 420
  421 TKLILLPNQI NVHFIDKDGK ETYMTTTDYC KSLDKKMKLL SYFKRYMIEH LVKAGANNVN 480
  481 IESDQISRMP HLHSWFRTTC AVVMHLTNGS VQLNFSDHMK LILCPRMSAI TYMDQEKNFR 540
  541 TYRFSTIVEN GVSKDLYQKI RYAQEKLRKM LEKMFT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: polo-PB, polo-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: