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Protein Overview: kto-PA

General Information:
Name(s) found: kto-PA / FBpp0074653 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene kohtalo is referred to in FlyBase by the symbol Dmel\kto (CG8491, FBgn0001324). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:19829714..19838044. It has the cytological map location 76D1. There is experimental evidence that it has the molecular function</span>: protein binding; RNA polymerase II transcription mediator activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of Wnt receptor signaling pathway; regulation of transcription from RNA polymerase II promoter. 20 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; eye disc; antennal disc; photoreceptor cell; embryonic heart. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2531 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    mediator complex [IDA][ISS][NAS]
    Biological Process: transcription from RNA polymerase II promoter [NAS]
    positive regulation of Wnt receptor signaling pathway [IMP]
    transcription initiation from RNA polymerase II promoter [ISS]
    regulation of transcription from RNA polymerase II promoter [IDA]
    Molecular Function: protein binding [IPI]
    RNA polymerase II transcription mediator activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSMLQEKRP LKRTRLGPPD IYPQDAKQRE DELTPTNVKH GFTTTPPLSD EFGTAHNSNV  60
   61 NASKVSAFFS GVLAKKEELM TLPDTGRKKQ QINCKDNFWP VSPRRKCTVD AWFKDLAGNK 120
  121 PLLSLAKRAP SFNKKEEIFI TLCENQVNMQ RATWFIKLSA AYTLSFTESK NKKRSIYDPA 180
  181 AEWTGNMIKF MKELLPKLQE YYQQNHDKSS SNGTTSGSLT AAGNGPASNG STGTSSINSV 240
  241 TGSSASTNVI PVPSMASPLP PIHSPANGQQ AAPGGGVNAG SVMPTTGSLG GVVGGPGSSV 300
  301 VGGAAGAGAA VPPGSTISGI GSQFEDSRNA LKYWKYCHQL SKYMYEESLL DRQEFLNWIL 360
  361 DLLDKMRTQA SFDEPLKKLV LSFALQYMHD FVQSERLCRK MAYIVSKKLA QLLNTVVEQQ 420
  421 TIKELDEPKL QQDPYELALQ EQMSCPHHRD IVLYLSTILQ IITIECPTAL VWSGIAAHRA 480
  481 PSSLLGSPLD HLPLAPSVLP MPTRCPRTNH EIRRQLRAAE SDIVLRTQHA EQRWFAAKWL 540
  541 SAGKNQYTSV LATLDHLDTH CFDRMEHNNS IDTLYAQIFP SPTVSRRREE DQVEPRPPYE 600
  601 PKQDKDTVRI LCEWAVSGQR WGEHRAMVVA ILLDKRQIDV TSTPADQQSS DKDDKDSLAS 660
  661 GAGLIDGLPV FQHVLMHFLD HDAPVLDEHV SSPQQRTEFT NLVQLFSALI RHDVFSHNAY 720
  721 MHTLISRGDL LLESVLVIKS GTTATKTSPP PPAPPPTTTH GFDDDGFGGG LDFKHNEFDD 780
  781 SNVDDDLDKL VQNIKEKGQQ HEAPDSPKIG PPGDGETNPG GSISRHYVYT KHFPIPQDDP 840
  841 SMSSYSSESN QRYILLFGVG KERDEKKHAV KKMSKEIGKL FTKKFSIDVA AAGHVKKHSR 900
  901 NEFNFEATTS KCQQMAYFDQ HVVTAQCAAN VLEQLNGFAL GNNNYLPVQE HVAFLFDLME 960
  961 LALNIYSLLE LCDSLLKELP EVEHQLQLKK SNLVRSYTTS LALYIVSILR RYHSCLLLSP1020
 1021 EQTLSVFEGV CRTIRHVSNP SECTSAERCI IAYLSDLHES CVLLQGKEQS TEYYQQLQCI1080
 1081 KRFKDIFNTP EQLDLPPQGY NPLLLQELFM APRRGGKLDP HWLGTLHESP ANVYSFVSNA1140
 1141 LIAVCRETDN ERLNDVALAC AELTASCNVL SEEWIYALQS LCSGSKSPRY PHLGGQVDIG1200
 1201 QLKTHNALAV FVCILVARHC FSLADFVSKF ALPTLARSVS AGGAELSVDA EAGARLTCHL1260
 1261 VLKLFKTLEI PQPGMYSVST SPNPLHAVGN DFSIRLSCDR HLLVGAHKTI PIAAVLAVLK1320
 1321 AILIVVDNAA LKTPLASGSG TSSGGLGGAF GSGKRSGFNT PVHPGSTPKS NEQRPADLSQ1380
 1381 ILGTSDLQLG SSLTSEPEAL QQPSVGGMEQ ISLLEFAQAV LKQICAQEHV LERCLKNAEQ1440
 1441 LCDMIIDEML TAKQAQRVLH MICYPEPEFN IISELDQRSM IVRILENLGQ WTLRISWLDL1500
 1501 QLMYRQSLSN NAELNVWLDT VARAAIDVFH MEEVVLPGAV KATHKPKPST WLVAPLIAKL1560
 1561 TPAVQGRILR VAGQVLESMN YFSKVSKSDC NSSGSGDERE KSNSCHSSNS YGLGGVPARN1620
 1621 KKMPLDYQPF LGLILTCLKG QDEYKENLLV SLYAQLSQCL QSFAELDTIG GIDEPQAREE1680
 1681 ILDALQLRFS LVGGMFEAIQ KNSTPTTDWA ILLAQLVCQG VVDLSCNREL FTTVVDMLAT1740
 1741 LVHSTLVSDD ERHYMNLMKK LKKEIGEKNN ASIRVIRQLL PLYKQPTEVI ACEHSGMDTK1800
 1801 GNKICDIDKK QLRISDKQRI SVWDILEGHK NPAPLSWVWF GAVKLERKPL TYEEAHRNLK1860
 1861 YHTHSLVKPS SYYYEPLPLP PEDIEPVPEK ICIKDEMKAD TPSSVDQSPS AVVGGTGRGR1920
 1921 GKGTTTRKRK PKNPKTPPVV NTQQQQPQLA QQPQQPQNVQ QQQLQQQQQQ QQHMQQQHMQ1980
 1981 QQQMQPNQMG QMPMNMPMNM QQFAPNPNNM MQQNAMLQQQ QQQQMQQMGN NPMQQQLNVG2040
 2041 GGNGQPNPQM NFMQQGPGGG GAGPQGMPGQ QQQWHNAPQQ QQPPQPYHNQ YAPHQQNMQS2100
 2101 NRIERPPLNA NSKQALSQML RQRQPFQQQA QQGPGGGFNP MQQQPQASQQ QPGPQQQMNP2160
 2161 NQMRQQQMNP QQNPQSVAAF NAMQQQPQQN AQQQQMNPNQ QQQQQFMRGG NMRPGMAPNQ2220
 2221 MNQMNMGGQG MSQNPMMQQQ IPQNMVGMVN PNANQMMQSG GAQGGNGVGV GVGVGVGGAG2280
 2281 NNPNMGMGGM PQQGMIQQQP QQQPQQQVQF QNFQNQYQQQ QQQGMQQQGG GAGVGVGVGM2340
 2341 APNQQQQQQA NMMGNFNPQM QQGNRNNPDF MAAAAVAQQQ QQQQQQQRVV PGGMMAGNRN2400
 2401 QYMNQAPNVT MSTMMGPGPG GVVGQVPPYA RQQSAGGGKP GVLNTQQQFQ QQQQQQQQLR2460
 2461 HQMMQLQGMG GGAGGGMGAG PQQGGGAVGG GAGGGMVPQQ QSMNQQQTPN LVAQLQRQNM2520
 2521 MGQQQYQPPP Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle