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Protein Overview: Krn-PA

General Information:
Name(s) found: Krn-PA / FBpp0074961 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Keren is referred to in FlyBase by the symbol Dmel\Krn (CG32179, FBgn0052179). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:17642664..17647376. It has the cytological map location 74E4. Based on sequence similarity, it is predicted to have molecular function</span>: growth factor activity; epidermal growth factor receptor binding. There is experimental evidence that it is involved in the biological process</span>: border follicle cell migration; MAPKKK cascade; positive regulation of epidermal growth factor receptor activity; ommatidial rotation. 17 alleles are reported. The phenotypes of these alleles are annotated with: eye; cephalopharyngeal skeleton; border follicle cell; wing; ommatidium; denticle belt. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 217 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDA]
    plasma membrane [ISS]
    Biological Process: MAPKKK cascade [IDA]
    ommatidial rotation [IMP]
    epidermal growth factor receptor signaling pathway [NAS]
    border follicle cell migration [IMP]
    positive regulation of epidermal growth factor receptor activity [IGI][IMP]
    Molecular Function: growth factor activity [ISS]
    epidermal growth factor receptor binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRAQDLLLLA TALIGAYLPL TAACSSRAIA KPRPTAAPIL PPDNVEISTT PRPNVTFPIF  60
   61 ACPPTYVAWY CLNDGTCFTV KIHNEILYNC ECALGFMGPR CEYKEIDGSY LPTRNRVMLE 120
  121 KASIVSGATL ALLFMAMCCV VLYLRHEKLQ KQKLHDSTTT TTTDGGCQNE GMDEVDGLRP 180
  181 LRPVRRPFGP CRILSLEEAH LQAKASNRPR HCNELLR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] PSI-BLAST 11.69897 No description for 2gy5A was found.
    2 View Details [135..217] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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