Protein Overview: Abl-PA, FBpp0311523

General Information:
Name(s) found:	FBpp0311523 [FlyBase] Abl-PA / FBpp0075116 [FlyBase]
Description(s) found: Found 26 descriptions. SHOW ALL	type=protein; loc=3L:complement(16615874..16618374,16619628..16619716,16619843..16619963,16620022..16620292,16620602..16621188,16621274..16621689,16621763..16622306,16639910..16640243); ID=FBpp0311523; name=Abl-PJ; parent=FBgn0000017,FBtr0345369; dbxref=FlyBase:FBpp0311523,FlyBase_Annotation_IDs:CG4032-PJ; MD5=e440ccb710a8bbcc86fe81e210ce6965; length=1620; release=r5.56; species=Dmel; [FlyBase] The gene Abl tyrosine kinase is referred to in FlyBase by the symbol Dmel\Abl (CG4032, FBgn0000017). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:16615461..16641674. It has the cytological map location 73B1-73B4. There is experimental evidence that it has the molecular function</span>: protein tyrosine kinase activity; protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of synaptic growth at neuromuscular junction; regulation of cell shape; central nervous system development; peptidyl-tyrosine phosphorylation; ventral furrow formation; dorsal closure; regulation of protein stability; cytoplasmic transport, nurse cell to oocyte; axon guidance; regulation of protein localization. 41 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: nervous system; multi-cell-component structure; commissure; external compound sense organ; embryonic nervous system; peripheral nervous system; organ system; antennal segment; extended germ band embryo; adult segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1620 amino acids
Gene Ontology:
Cellular Component:	adherens junction [NAS][TAS] cell-cell junction [IDA] cytoplasm [IDA][NAS] muscle tendon junction [IDA] cytosol [IDA] apical cortex [IDA] extrinsic to plasma membrane [IDA]
Biological Process:	dorsal closure [IMP][NAS] regulation of cell shape [IMP][NAS] ventral furrow formation [IMP] peptidyl-tyrosine phosphorylation [IMP] signal transduction [IEA] regulation of protein localization [IDA] regulation of actin polymerization or depolymerization [TAS] axon guidance [IGI][IMP] negative regulation of synaptic growth at neuromuscular junction [IMP] protein amino acid phosphorylation [NAS] cytoplasmic transport, nurse cell to oocyte [IMP] central nervous system development [IGI] regulation of protein stability [IMP] morphogenesis of an epithelium [NAS]
Molecular Function:	magnesium ion binding [IEA] ATP binding [IEA][NAS] protein tyrosine kinase activity [IDA][IMP][ISS][NAS] protein binding [IPI] non-membrane spanning protein tyrosine kinase activity [IEA][ISS] manganese ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAQQGKDRG AHSGGGGSGA PVSCIGLSSS PVASVSPHCI SSSSGVSSAP LGGGSTLRGS  60
   61 RIKSSSSGVA SGSGSGGGGG GSGSGLSQRS GGHKDARCNP TVGLNIFTEH NEALLQSRPL 120
  121 PHIPAGSTAA SLLADAAELQ QHQQDSGGLG LQGSSLGGGH SSTTSVFESA HRWTSKENLL 180
  181 APGPEEDDPQ LFVALYDFQA GGENQLSLKK GEQVRILSYN KSGEWCEAHS DSGNVGWVPS 240
  241 NYVTPLNSLE KHSWYHGPIS RNAAEYLLSS GINGSFLVRE SESSPGQRSI SLRYEGRVYH 300
  301 YRISEDPDGK VFVTQEAKFN TLAELVHHHS VPHEGHGLIT PLLYPAPKQN KPTVFPLSPE 360
  361 PDEWEICRTD IMMKHKLGGG QYGEVYEAVW KRYGNTVAVK TLKEDTMALK DFLEEAAIMK 420
  421 EMKHPNLVQL IGVCTREPPF YIITEFMSHG NLLDFLRSAG RETLDAVALL YMATQIASGM 480
  481 SYLESRNYIH RDLAARNCLV GDNKLVKVAD FGLARLMRDD TYTAHAGAKF PIKWTAPEGL 540
  541 AYNKFSTKSD VWAFGVLLWE IATYGMSPYP AIDLTDVYHK LDKGYRMERP PGCPPEVYDL 600
  601 MRQCWQWDAT DRPTFKSIHH ALEHMFQESS ITEAVEKQLN ANATSASSSA PSTSGVATGG 660
  661 GATTTTAASG CASSSSATAS LSLTPQMVKK GLPGGQALTP NAHHNDPHQQ QASTPMSETG 720
  721 STSTKLSTFS SQGKGNVQMR RTTNKQGKQA PAPPKRTSLL SSSRDSTYRE EDPANARCNF 780
  781 IDDLSTNGLA RDINSLTQRY DSETDPAADP DTDATGDSLE QSLSQVIAAP VTNKMQHSLH 840
  841 SGGGGGGIGP RSSQQHSSFK RPTGTPVMGN RGLETRQSKR SQLHSQAPGP GPPSTQPHHG 900
  901 NNGVVTSAHP ITVGALDVMN VKQVVNRYGT LPKGARIGAY LDSLEDSSEA APALPATAPS 960
  961 LPPANGHATP PAARLNPKAS PIPPQQMIRS NSSGGVTMQN NAAASLNKLQ RHRTTTEGTM1020
 1021 MTFSSFRAGG SSSSPKRSAS GVASGVQPAL ANLEFPPPPL DLPPPPEEFE GGPPPPPPAP1080
 1081 ESAVQAIQQH LHAQLPNNGN ISNGNGTNNN DSSHNDVSNI APSVEEASSR FGVSLRKREP1140
 1141 STDSCSSLGS PPEDLKEKLI TEIKAAGKDT APASHLANGS GIAVVDPVSL LVTELAESMN1200
 1201 LPKPPPQQQQ KLTNGNSTGS GFKAQLKKVE PKKMSAPMPK AEPANTIIDF KAHLRRVDKE1260
 1261 KEPATPAPAP ATVAVANNAN CNTTGTLNRK EDGSKKFSQA MQKTEIKIDV TNSNVEADAG1320
 1321 AAGEGDLGKR RSTGSINSLK KLWEQQPPAP DYATSTILQQ QPSVVNGGGT PNAQLSPKYG1380
 1381 MKSGAINTVG TLPAKLGNKQ PPAAPPPPPP NCTTSNSSTT SISTSSRDCT SRQQASSTIK1440
 1441 TSHSTQLFTD DEEQSHTEGL GSGGQGSADM TQSLYEQKPQ IQQKPAVPHK PTKLTIYATP1500
 1501 IAKLTEPASS ASSTQISRES ILELVGLLEG SLKHPVNAIA GSQWLQLSDK LNILHNSCVI1560
 1561 FAENGAMPPH SKFQFRELVT RVEAQSQHLR SAGSKNVQDN ERLVAEVGQS LRQISNALNR1620
 1621

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.67

Protein Overview: Abl-PA, FBpp0311523

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: