Protein Overview: E(z)-PB, E(z)-PA

General Information:
Name(s) found:	E(z)-PB / FBpp0271846 [FlyBase] E(z)-PA / FBpp0076008 [FlyBase]
Description(s) found: Found 33 descriptions. SHOW ALL	The gene Enhancer of zeste is referred to in FlyBase by the symbol Dmel\E(z) (CG6502, FBgn0000629). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:10627675..10631230. It has the cytological map location 67E5. There is experimental evidence that it has the molecular function</span>: histone methyltransferase activity (H3-K27 specific); protein binding; histone methyltransferase activity (H3-K9 specific); histone methyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: histone methylation; axon guidance; histone H3-K27 methylation; dendrite morphogenesis; histone H3-K9 methylation; muscle organ development; syncytial blastoderm mitotic cell cycle; neurogenesis. 111 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: adult segment; thoracic segment; imaginal precursor; dorsal thoracic disc; female germline cyst; larval thorax; adult metathoracic segment; organ system; peripheral nervous system; adult abdominal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene Enhancer of zeste is referred to in FlyBase by the symbol Dmel\E(z) (CG6502, FBgn0000629). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:10627675..10631230. It has the cytological map location 67E5. There is experimental evidence that it has the molecular function</span>: histone methyltransferase activity (H3-K27 specific); protein binding; histone methyltransferase activity (H3-K9 specific); histone methyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: histone methylation; axon guidance; histone H3-K27 methylation; dendrite morphogenesis; histone H3-K9 methylation; muscle organ development; syncytial blastoderm mitotic cell cycle; neurogenesis. 111 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: adult segment; thoracic segment; imaginal precursor; dorsal thoracic disc; female germline cyst; larval thorax; adult metathoracic segment; organ system; peripheral nervous system; adult abdominal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	760 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS] ESC/E(Z) complex [IDA]
Biological Process:	muscle organ development [IMP] cuticle hydrocarbon biosynthetic process [IMP] syncytial blastoderm mitotic cell cycle [IMP] histone methylation [IDA][IMP][TAS] axon guidance [IMP] neurogenesis [IMP] chromatin silencing [NAS] histone H3-K9 methylation [IDA] pheromone metabolic process [NAS] histone H3-K27 methylation [IDA][IMP] dendrite morphogenesis [IMP]
Molecular Function:	DNA binding [IEA] protein binding [IPI] histone methyltransferase activity [IDA][IMP] histone methyltransferase activity (H3-K9 specific) [IDA] histone methyltransferase activity (H3-K27 specific) [IDA][IMP][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSTKVPPEW KRRVKSEYIK IRQQKRYKRA DEIKEAWIRN WDEHNHNVQD LYCESKVWQA  60
   61 KPYDPPHVDC VKRAEVTSYN GIPSGPQKVP ICVINAVTPI PTMYTWAPTQ QNFMVEDETV 120
  121 LHNIPYMGDE VLDKDGKFIE ELIKNYDGKV HGDKDPSFMD DAIFVELVHA LMRSYSKELE 180
  181 EAAPGTATAI KTETLAKSKQ GEDDGVVDVD ADGESPMKLE KTDSKGDLTE VEKKETEEPL 240
  241 ETEDADVKPD VEEVKDKLPF PAPIIFQAIS ANFPDKGTAQ ELKEKYIELT EHQDPERPQE 300
  301 CTPNIDGIKA ESVSRERTMH SFHTLFCRRC FKYDCFLHRL QGHAGPNLQK RRYPELKPFA 360
  361 EPCSNSCYML IDGMKEKLAA DSKTPPIDSC NEASSEDSND SNSQFSNKDF NHENSKDNGL 420
  421 TVNSAAVAEI NSIMAGMMNI TSTQCVWTGA DQALYRVLHK VYLKNYCAIA HNMLTKTCRQ 480
  481 VYEFAQKEDA EFSFEDLRQD FTPPRKKKKK QRLWSLHCRK IQLKKDSSSN HVYNYTPCDH 540
  541 PGHPCDMNCS CIQTQNFCEK FCNCSSDCQN RFPGCRCKAQ CNTKQCPCYL AVRECDPDLC 600
  601 QACGADQFKL TKITCKNVCV QRGLHKHLLM APSDIAGWGI FLKEGAQKNE FISEYCGEII 660
  661 SQDEADRRGK VYDKYMCSFL FNLNNDFVVD ATRKGNKIRF ANHSINPNCY AKVMMVTGDH 720
  721 RIGIFAKRAI QPGEELFFDY RYGPTEQLKF VGIEREMEIV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: E(z)-PB, E(z)-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: