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Protein Overview: hay-PB, hay-PA

General Information:
Name(s) found: hay-PB / FBpp0113091 [FlyBase]
hay-PA / FBpp0075982 [FlyBase]
Description(s) found:
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  • gi|94400453|gb|ABF17890.1| FI01118p [Drosophila melanogaster] [NCBI NR]
  • gi|7294816|gb|AAF50150.1| haywire, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|68068031|sp|Q02870.2|ERCC3_DROME RecName: Full=DNA excision repair protein haywire; AltName: Full=ATP-dependent DNA helicase hay; AltName: Full=ERCC-3 homolog protein; AltName: Full=ERCC3Dm [NCBI NR]
  • gi|24662247|ref|NP_524020.2| haywire, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|221331068|ref|NP_001137931.1| haywire, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|220902549|gb|ACL83286.1| haywire, isoform B [Drosophila melanogaster] [NCBI NR]
  • DNA excision repair protein haywire OS=Drosophila melanogaster GN=hay PE=1 SV=2 [Swiss-Prot]
  • The gene haywire is referred to in FlyBase by the symbol Dmel\hay (CG8019, FBgn0001179). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:10624227..10627069. It has the cytological map location 67E5. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity; helicase activity. There is experimental evidence that it is involved in the biological process</span>: adult locomotory behavior; regulation of alternative nuclear mRNA splicing, via spliceosome; response to UV. 29 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; macrochaeta; chaeta; wing; imaginal disc; microchaeta; larval central nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG8019-PA translation from_gene[CG8019 hay FBgn0001179] seq_release:3 mol_weight=90349 cds_boundaries:(3L:10,588,937..10,591,447[+]) aa_length:798 transcript_info:[CG8019-RA seq_release:3] gene_info:[gene symbol:hay FBgn0001179 gene_boundaries:(3L:10, [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VTA2) HAY protein [DrosMelano7227.FASTAC.txt]
  • (AE003547) hay gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG8019-PA [Drosophila melanogaster]gi|24662247|ref|NP_524020.2| CG8019-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3L:join(10624508..10624559,10624620..10626418,10626476..10627021); ID=FBpp0075982; name=hay-PA; parent=FBgn0001179,FBtr0076253; dbxref=FlyBase:FBpp0075982,FlyBase_Annotation_IDs:CG8019-PA,GB_protein:AAF50150.1,REFSEQ:NP_524020,GB_protein [fly-100309-contam.fasta]
  • type=protein; loc=3L:join(10624508..10624559,10624620..10626418,10626476..10627021); ID=FBpp0113091; name=hay-PB; parent=FBgn0001179,FBtr0114599; dbxref=FlyBase:FBpp0113091,FlyBase_Annotation_IDs:CG8019-PB,REFSEQ:NP_001137931,GB_protein:ACL83286; MD5=9bbb [fly-100309-contam.fasta]
  • DNA excision repair protein haywire (ATP-dependent DNA helicase hay) (ERCC-3 homolog protein) [nr-271106-contam.fasta]
  • FI01118p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • haywire CG8019-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG8019-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3L:join(10624508..10624559,10624620..10626418,10626476..10627021); ID=FBpp0075982; name=hay-PA; parent=FBgn0001179,FBtr0076253; dbxref=FlyBase:FBpp0075982,FlyBase_Annotation_IDs:CG8019-PA,GB_protein:AAF50150.1,REFSEQ:NP_524020,GB_protein:AAF50150; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:join(10624508..10624559,10624620..10626418,10626476..10627021); ID=FBpp0113091; name=hay-PB; parent=FBgn0001179,FBtr0114599; dbxref=FlyBase:FBpp0113091,FlyBase_Annotation_IDs:CG8019-PB,REFSEQ:NP_001137931,GB_protein:ACL83286; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:join(10624508..10624559,10624620..10626418,10626476..10627021); ID=FBpp0075982; name=hay-PA; parent=FBgn0001179,FBtr0076253; dbxref=FlyBase:FBpp0075982,FlyBase_Annotation_IDs:CG8019-PA,GB_protein:AAF50150.1,REFSEQ:NP_524020,GB_protein:AAF50150; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3L:join(10624508..10624559,10624620..10626418,10626476..10627021); ID=FBpp0113091; name=hay-PB; parent=FBgn0001179,FBtr0114599; dbxref=FlyBase:FBpp0113091,FlyBase_Annotation_IDs:CG8019-PB,REFSEQ:NP_001137931,GB_protein:ACL83286; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • DNA excision repair protein haywire OS=Drosophila melanogaster GN=hay PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • Haywire, isoform B OS=Drosophila melanogaster GN=hay PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3L:join(10624508..10624559,10624620..10626418,10626476..10627021); ID=FBpp0075982; name=hay-PA; parent=FBgn0001179,FBtr0076253; dbxref=FlyBase:FBpp0075982,FlyBase_Annotation_IDs:CG8019-PA,GB_protein:AAF50150.1,REFSEQ:NP_524020,GB_protein:AAF50150,FlyMine:FBpp0075982,modMine:FBpp0075982; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3L:join(10624508..10624559,10624620..10626418,10626476..10627021); ID=FBpp0113091; name=hay-PB; parent=FBgn0001179,FBtr0114599; dbxref=FlyBase:FBpp0113091,FlyBase_Annotation_IDs:CG8019-PB,REFSEQ:NP_001137931,GB_protein:ACL83286; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3L:join(10631408..10631459,10631520..10633318,10633376..10633921); ID=FBpp0075982; name=hay-PA; parent=FBgn0001179,FBtr0076253; dbxref=FlyBase:FBpp0075982,FlyBase_Annotation_IDs:CG8019-PA,GB_protein:AAF50150.1,REFSEQ:NP_524020,GB_protein:AAF50150,FlyMine:FBpp0075982,modMine:FBpp0075982; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:join(10631408..10631459,10631520..10633318,10633376..10633921); ID=FBpp0113091; name=hay-PB; parent=FBgn0001179,FBtr0114599; dbxref=FlyBase:FBpp0113091,FlyBase_Annotation_IDs:CG8019-PB,REFSEQ:NP_001137931,GB_protein:ACL83286; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:join(10631408..10631459,10631520..10633318,10633376..10633921); ID=FBpp0075982; name=hay-PA; parent=FBgn0001179,FBtr0076253; dbxref=FlyBase:FBpp0075982,FlyBase_Annotation_IDs:CG8019-PA,GB_protein:AAF50150.1,REFSEQ:NP_524020,GB_protein:AAF50150,FlyMine:FBpp0075982,modMine:FBpp0075982; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3L:join(10631408..10631459,10631520..10633318,10633376..10633921); ID=FBpp0113091; name=hay-PB; parent=FBgn0001179,FBtr0114599; dbxref=FlyBase:FBpp0113091,FlyBase_Annotation_IDs:CG8019-PB,REFSEQ:NP_001137931,GB_protein:ACL83286; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q02870, Haywire, isoform B OS=Drosophila melanogaster GN=hay PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0075982 type=protein; loc=3L:join(10631408..10631459,10631520..10633318,10633376..10633921); ID=FBpp0075982; name=hay-PA; parent=FBgn0001179,FBtr0076253; dbxref=FlyBase:FBpp0075982,FlyBase_Annotation_IDs:CG8019-PA,GB_protein:AAF50150.1,REFSEQ:NP_524020,GB_protein:AAF50150,FlyMine:FBpp0075982,modMine:FBpp0075982; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0113091 type=protein; loc=3L:join(10631408..10631459,10631520..10633318,10633376..10633921); ID=FBpp0113091; name=hay-PB; parent=FBgn0001179,FBtr0114599; dbxref=FlyBase:FBpp0113091,FlyBase_Annotation_IDs:CG8019-PB,REFSEQ:NP_001137931,GB_protein:ACL83286; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3L:join(10631408..10631459,10631520..10633318,10633376..10633921); ID=FBpp0075982; name=hay-PA; parent=FBgn0001179,FBtr0076253; dbxref=FlyBase:FBpp0075982,FlyBase_Annotation_IDs:CG8019-PA,GB_protein:AAF50150.1,REFSEQ:NP_524020,GB_protein:AAF50150,UniProt/Swiss-Prot:Q02870,FlyMine:FBpp0075982,modMine:FBpp0075982; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3L:join(10631408..10631459,10631520..10633318,10633376..10633921); ID=FBpp0113091; name=hay-PB; parent=FBgn0001179,FBtr0114599; dbxref=FlyBase:FBpp0113091,FlyBase_Annotation_IDs:CG8019-PB,REFSEQ:NP_001137931,GB_protein:ACL83286,UniProt/Swiss-Prot:Q02870; MD5=9bbb22c3e228bee303d9f1e8ca6911a4; length=798; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 798 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][NAS]
    holo TFIIH complex [ISS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    nucleotide-excision repair [ISS]
    adult locomotory behavior [IMP]
    response to UV [IMP]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    general RNA polymerase II transcription factor activity [ISS]
    helicase activity [ISS]
    ATP-dependent DNA helicase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPPKKSRKD RSGGDKFGKK RRAEDEAFTQ LVDDNDSLDA TESEGIPGAA SKNAETNDEQ  60
   61 INTDEYGAKD YRSQMQLRPD HGNRPLWVAP NGHVFLESFS PVYKHAHDFL IAISEPVCRP 120
  121 EHIHEYKLTA YSLYAAVSVG LQTHDIVEYL KRLSKTSIPE GILEFIRLCT LSYGKVKLVL 180
  181 KHNKYFIESP HPEVLQKLLK DPVIQKCRLI RSEGEDFIQG TLDGKAITQF GTKLPPGATD 240
  241 KPTPDPAAAA GADGTTAVPE DITDFYEKID KEEEDEDEAN LKTVSFEVAQ EKIEVIQKRC 300
  301 IEIEHPLLAE YDFRNDTNNP DINIDLKPAA VLRPYQEKSL RKMFGNGRAR SGVIVLPCGA 360
  361 GKSLVGVTAC CTVRKRALVL CNSGVSVEQW KQQFKMWSTA DDSMICRFTS EAKDKPMGCG 420
  421 ILVTTYSMIT HTQKRSWEAE QTMRWLQEQE WGIMVLDEVH TIPAKMFRRV LTIVQSHCKL 480
  481 GLTATLLRED DKIADLNFLI GPKLYEANWL ELQKKGYIAR VQCAEVWCPM SPEFYREYLT 540
  541 TKTSKKMLLY VMNPSKFRSC QFLIKYHEQR GDKTIVFSDN VFALKHYAIK MNKPFIYGPT 600
  601 SQNERIQILQ NFKFNSKVNT IFVSKVADTS FDLPEANVLI QISSHGGSRR QEAQRLGRIL 660
  661 RAKKGAIAEE YNAFFYTLVS QDTMEMSYSR KRQRFLVNQG YSYKVITHLK GMDTDSDLMY 720
  721 GTQEEQGQLL QLVLSASDLD CEDEKLPGEP GYRPSGSGGA VRRVGGLSSM SGGDDAIYYE 780
  781 HRKKNIGSVH PLFKKFRG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle